Perioperative Outcomes of Coronary Artery Bypass Grafting: Effects of Metabolic Syndrome and Patient’s Sex

Brackbill, Marcia L.; Sytsma, Christine S.; Sykes, Kristina

doi:10.4037/ajcc2009718

Cited by 22 publications

(18 citation statements)

References 17 publications

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“…In our study, the prevalence of 42% of patients with the metabolic syndrome correlates with others studies where the metabolic syndrome and CABG were investigated (46, 47, 51%) 10, 29,30. However, in an overview of the metabolic syndrome in young South African Asian patients with myocardial infarction, the prevalence of the metabolic syndrome, depending on the definition, was as high as 69% 26…”

Section: Discussionsupporting

confidence: 86%

The effect of the metabolic syndrome on the risk and outcome of coronary artery bypass graft surgery : cardiovascular topics

Swart¹,

Jager

Kemp

et al. 2012

CVJA

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BackgroundThe individual components of the metabolic syndrome are risk factors for coronary artery disease. The underlying pathophysiology of a low-grade inflammatory process postulates that the metabolic syndrome could compromise a procedure such as coronary artery bypass graft surgery (CABG) done on cardiopulmonary bypass (CPB).MethodsFrom a single institution, 370 patients with the metabolic syndrome (IDF and ATP III criteria) and 503 patients without the metabolic syndrome were identified. The influence of the metabolic syndrome on the pre-operative core risk factors for CABG mortality as well as its effect on the mortality and major morbidity post surgery were investigated.ResultsPatients with the metabolic syndrome were operated on less urgently than those without the metabolic syndrome. The EuroSCORE was also lower in those with the metabolic syndrome. Patients with the metabolic syndrome required fewer units of homologous red blood cells, but stayed statistically longer in hospital.ConclusionsIn this surgical population the metabolic syndrome had no detrimental clinical effect on either the pre-operative risk factors or the outcome after CABG.

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Section: Discussionsupporting

confidence: 86%

The effect of the metabolic syndrome on the risk and outcome of coronary artery bypass graft surgery : cardiovascular topics

Swart¹,

Jager

Kemp

et al. 2012

CVJA

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“…As MS patients have a high risk of developing coronary artery disease, they should be evaluated in line with coronary artery disease guidelines 10-14,156.…”

Section: Discussionmentioning

confidence: 99%

“…Although it has been shown to be a predictor of adverse events after cardiovascular interventions, and its association with early and late mortality and morbidity following coronary artery bypass graft (CABG) surgery has recently been reported,10 severalstudies failed to find such an association 11-13. We hypothesised that the MS could adversely affect the outcome in patients undergoing CABG surgery and designed a prospective study to determine the impact of the MS on postoperative morbidity and mortality rates after CABG.…”

Section: Introductionmentioning

confidence: 99%

The effects of the metabolic syndrome on coronary artery bypass grafting surgery

Özkan¹,

Özdemir²,

Uğur³

et al. 2017

CVJA

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SummaryBackgroundThe metabolic syndrome (MS) is a clustering of factors that are associated with increased cardiovascular risk. A low-grade inflammatory process acts as the underlying pathophysiology, which suggests that the MS may have a detrimental effect on coronary interventions, including coronary artery bypass grafting (CABG) surgery performed with cardiopulmonary bypass (CPB). We aimed to evaluate the effect of the MS on morbidity and mortality rates in the early postoperative period in patients undergoing CABG.MethodsWe prospectively included 152 patients (109 males and 43 females; mean age 60.1 ± 8.6 years) who underwent elective CABG on CPB between January and September 2011. Early postoperative morbidity and mortality rates were compared between subjects with and without the MS. Diagnosis of the MS was based on the American National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria.ResultsOf the study group, 64 patients (42%) had the MS. The two groups were similar in age and gender. In the postoperative period, rates of atrial fibrillation, wound infection, pulmonary complications, and lengths of intubation, hospitalisation and intensive care unit stay were significantly higher in MS patients (p < 0.01). The MS was significantly associated with wound infection (OR 6.64, 95% CI: 1.72–25.75), pulmonary complications (OR 6.44, 95% CI: 1.58–26.33), arrhythmia (OR 5.47, 95% CI: 1.50–19.97) and prolonged intubation (OR 1.17, 95% CI: 1.05–1.32). The mortality rate was 3.1% in the MS group and 1.1% in the non-MS group, with no significant difference (p > 0.05).ConclusionThe MS was associated with a higher rate of early postoperative morbidity following CABG, without having a significant effect on the mortality rate.

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“…23 In addition, an evaluation of men underoing gastric bypass surgery for morbid obesity found MetS to be the single largest risk factor for prolonged length of stay. 24 In this study, we evaluated the impact of MetS on length of stay, cost, and discharge status after PSF.…”

Section: Methodsmentioning

confidence: 99%

Metabolic Syndrome and Lumbar Spine Fusion Surgery

Memtsoudis¹,

Kirksey²,

Ma³

et al. 2012

Spine

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Study Design Analysis of the National Inpatient Sample database from 2000 to 2008. Objective To identify if metabolic syndrome is an independent risk factor for increased major perioperative complications, cost, length of stay and non-routine discharge. Summary of Background Data Metabolic syndrome is a combination of medical disorders that has been shown to increase the health risk of the general population. No study has analyzed its impact in the perioperative spine surgery setting. Methods We obtained the National Inpatient Sample from the Hospital Cost and Utilization Project for each year between 2000 and 2008. All patients undergoing primary posterior lumbar spine fusion were identified and separated into groups with and without metabolic syndrome. Patient demographics and health care system related parameters were compared. The outcomes of major complications, non-routine discharge, length of hospital stay and hospitalization charges were assessed for both groups. Regression analysis was performed to identify if the presence of metabolic syndrome was an independent risk factor for each outcome. Results An estimated 1,152,747 primary posterior lumbar spine fusion were performed between 2000 and 2008 in the US. The prevalence of metabolic syndrome as well as the comorbidities of the patients increased significantly over time. Patients with metabolic syndrome had significantly longer length of stay, higher hospital charges, higher rates of non-routine discharges and increased rates of major life-threatening complications compared to patients without metabolic syndrome. Conclusion Patients with metabolic syndrome undergoing primary posterior lumbar spinal fusion represent an increasing financial burden on the health care system. Clinicians should recognize that metabolic syndrome represents a risk factor for increased perioperative morbidity.

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Perioperative Outcomes of Coronary Artery Bypass Grafting: Effects of Metabolic Syndrome and Patient’s Sex

Cited by 22 publications

References 17 publications

The effect of the metabolic syndrome on the risk and outcome of coronary artery bypass graft surgery : cardiovascular topics

The effect of the metabolic syndrome on the risk and outcome of coronary artery bypass graft surgery : cardiovascular topics

The effects of the metabolic syndrome on coronary artery bypass grafting surgery

Metabolic Syndrome and Lumbar Spine Fusion Surgery

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