Perioperative pharmacokinetics and pharmacodynamics of meloxicam in emus (<i>Dromaius novaehollandiae)</i> of different age groups using nonlinear mixed effect modelling

Castiñeiras, Diego; Armitage, Lucy; Lamas, L. P.; Baere, Siegrid De; Croubels, Siska; Pelligand, Ludovic

doi:10.1111/jvp.12923

Cited by 10 publications

(12 citation statements)

References 52 publications

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“…In studies conducted on different species, the effect of age on the volume of meloxicam distribution showed differences. The volume of distribution of meloxicam was larger in 5-week-old emu than in 66-week-old emu and lower in 18-week-old chickens than in 24-month-old chickens (Castineiras et al, 2021;Gildersleve, 2015).…”

Section: Discussionmentioning

confidence: 96%

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Age‐related changes in the pharmacokinetics of meloxicam after intravenous administration in sheep

Coskun,

Corum,

Durna Corum

et al. 2023

Vet Pharm & Therapeutics

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The pharmacokinetics of meloxicam was studied in 1‐, 6‐, and 12‐month‐old sheep following a single intravenous (i.v.) dose of 1 mg/kg. The experiments were carried out when the Romanov sheep were 1 month old (7.93 ± 0.91 kg), 6 months old (27.47 ± 4.91 kg), and 12 months old (37.10 ± 3.64 kg). Meloxicam concentration in plasma was determined by high‐performance liquid chromatography and the data collected were evaluated by non‐compartmental kinetic analysis. Meloxicam was detected in the plasma up to 72 h following i.v. administration in all age groups. The volume of distribution at steady state (Vdss) and total body clearance (ClT) were significantly higher in 1‐month‐old (304.87 mL/kg and 16.57 mL/h/kg) than in 12‐month‐old (193.43 mL/kg and 10.50 mL/h/kg) sheep. The area under the concentration–time curve from 0 to 72 h value of meloxicam was lower in 1‐month‐old (58.51 h*μg/mL) compared to 12‐month‐old (92.59 h*μg/mL) sheep. There was no difference in t1/2ʎz value in different age groups. The body extraction ratio values for meloxicam ranged from 0.0186 to 0.0719 after i.v. administration in all age groups. Meloxicam showed an increase in plasma concentration and a decrease in Vdss and ClT in 12‐month‐old compared to 1‐month‐old sheep. Compared to 1‐month‐old and 12‐month‐old sheep, there was no difference in these parameters in 6‐month‐old sheep. Because the age of sheep has an influence on the pharmacokinetics of meloxicam, dosage apparently may need to be adjusted for age.

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Section: Discussionmentioning

confidence: 96%

“…The effect of age on the pharmacokinetics of meloxicam has been demonstrated in calves (Mosher et al, 2012), emu (Castineiras et al, 2021), and chicken (Gildersleve, 2015). These studies in different species show that the pharmacokinetics of meloxicam varies with age.…”

mentioning

confidence: 99%

Age‐related changes in the pharmacokinetics of meloxicam after intravenous administration in sheep

Coskun,

Corum,

Durna Corum

et al. 2023

Vet Pharm & Therapeutics

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“…The current clearance value was calculated as 26.48 ml/kg/h in Jing Hong laying hens, which was similar to broiler chickens (25 ml/kg/h, Baert & De Backer, 2003), however, greater than those reported in African grey parrots (2.18 ml/kg/h, Montesinos et al, 2017), geese (9.75 ml/kg/h, Sartini et al, 2020), and parrots (12.2 ml/kg/h, Molter et al, 2013). Age effects have been observed for the clearance of meloxicam in emus, and the clearance would gradually decrease as the age increases (Castineiras et al, 2021). Whether the similar age effect also exists in laying hens needs further research.…”

Section: Discussionmentioning

confidence: 99%

“…The pharmacokinetics of meloxicam have been reported in different avian species, including parrots (Guzman et al, 2017), African penguins (Morrison et al, 2018), American flamingos (Sim & Cox, 2018), brown pelicans (Horgan et al, 2020), emus (Castineiras et al, 2021), zebra finches (Miller et al, 2019), and grey parrots (Montesinos et al, 2019). The breed differences in the pharmacokinetics of meloxicam have also been reported in laying hens, including Columbian Wyandotte, White leghorn, and Bantam Cochin hens (Souza et al, 2017, 2018, 2021, and 2022).…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics of meloxicam in laying hens after single intravenous, oral, and intramuscular administration

Shao

Yang

Chen

et al. 2022

Vet Pharm & Therapeutics

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The objective of this study was to determine the pharmacokinetics of meloxicam after a single intravenous (IV), intramuscular (IM), and oral (PO) dose at 1 mg/kg body weight in Jing Hong laying hens. Blood samples were collected at predetermined time points. Plasma meloxicam concentrations were determined using a validated high‐performance liquid chromatography (HPLC) assay method and then subjected to a non‐compartmental analysis. After IV administration, meloxicam had a mean (±SD) volume of distribution at steady‐state (Vdss) of 206.50 ± 25.23 ml/kg, a terminal half‐life (t1/2λ) of 5.45 ± 0.53 h, and a total body clearance (Cl) of 26.48 ± 4.13 ml/h/kg. After PO and IM administration, meloxicam was absorbed relatively rapidly: the peak concentrations (Cmaxs) of 3.04 ± 0.56 and 8.94 ± 2.31 μg/ml were observed at 3.08 and 0.80 h, respectively. After PO and IM administration, the absolute bioavailability (F) was determined as 70.13% and 125.50%, respectively. Assuming that hens shared the same analgesic threshold of meloxicam (0.5 μg/ml) with humans, the plasma concentrations after three different routes (PO, IM, and IV) of administration were above this value for 16.7, 19.2, and 14.9 h, respectively.

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“…Future meloxicam pharmacokinetic and drug residue elimination studies should be performed in aged backyard hens since differences in pharmacokinetic parameters have been reported for young (< 18 weeks of age) vs. adult birds ( 41 , 42 ), but geriatric non-laying birds were not evaluated. In addition, efficacy of meloxicam for treating pain should be investigated in a comparable group of chickens to assess the pharmacodynamics of this drug.…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetic Parameters and Estimating Extra-Label Tissue Withdrawal Intervals Using Three Approaches and Various Matrices for Domestic Laying Chickens Following Meloxicam Administration

Richards

Dutch²,

Burmas

et al. 2022

Front. Vet. Sci.

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Meloxicam is commonly prescribed for treating chickens in backyard or small commercial operations despite a paucity of scientific data establishing tissue withdrawal interval recommendations following extra-label drug use (ELDU). Historically, ELDU withdrawal intervals (WDIs) following meloxicam administration to chickens have been based on the time when meloxicam concentrations fall below detectable concentrations in plasma and egg samples. To date, no studies have addressed tissue residues. ELDU WDIs are commonly calculated using terminal elimination half-lives derived from pharmacokinetic studies. This study estimated pharmacokinetic parameters for laying hens following meloxicam administration and compared ELDU WDIs calculated using tissue terminal elimination half-lives vs. those calculated using FDA tolerance and EMA's maximum regulatory limit statistical methods, respectively. In addition, ELDU WDIs were calculated using plasma meloxicam concentrations from live birds to determine if plasma data could be used as a proxy for estimating tissue WDIs. Healthy domestic hens were administered meloxicam at 1 mg/kg intravenous (IV) once, 1 mg/kg orally (PO) once daily for eight doses or 1 mg/kg PO twice daily for 20 doses. Analytical method validation was performed and meloxicam concentrations were quantified using high-performance liquid chromatography. In general, the terminal elimination technique resulted in the longest ELDU WDIs, followed by the FDA tolerance and then EMA's maximum residue limit methods. The longest ELDU WDIs were 72, 96, and 384 (or 120 excluding fat) h for the IV, PO once daily for eight doses, and PO twice daily for 20 doses, respectively. Plasma data are a possible dataset for estimating a baseline for tissue ELDU WDI estimations when tissue data are not available for chickens treated with meloxicam. Finally, pharmacokinetic parameters were similar in laying hens to those published for other avian species.

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Perioperative pharmacokinetics and pharmacodynamics of meloxicam in emus (Dromaius novaehollandiae) of different age groups using nonlinear mixed effect modelling

Cited by 10 publications

References 52 publications

Age‐related changes in the pharmacokinetics of meloxicam after intravenous administration in sheep

Age‐related changes in the pharmacokinetics of meloxicam after intravenous administration in sheep

Pharmacokinetics of meloxicam in laying hens after single intravenous, oral, and intramuscular administration

Pharmacokinetic Parameters and Estimating Extra-Label Tissue Withdrawal Intervals Using Three Approaches and Various Matrices for Domestic Laying Chickens Following Meloxicam Administration

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