Perioperative Precision Medicine and Bedside Decision Making: Still a Case of Great Expectations?

Khanna, Ashish K.; Gan, T. J.

doi:10.1213/ane.0000000000006001

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2024

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“…5 Future trials will not only include patient clinical data and procedure information but genomics, pharmacogenetics, epigenetic data, and more. 6 Patient-level pharmacogenetic data may ultimately be able to tell us the optimal drug regimen and optimal dosage of each drug to prescribe a given patient for anxiolysis, analgesia, anesthesia, and antiemetic prophylaxis based upon his or her unique genetic profile. 7 This evolution is tied closely to advances in machine learning, artificial intelligence, and implementation science.…”

Section: Jama Networkmentioning

confidence: 99%

“…Randomized, embedded, multifactorial, adaptive platform (REMAP) trials are well suited to ERAS protocols and can test multiple interventions simultaneously . Future trials will not only include patient clinical data and procedure information but genomics, pharmacogenetics, epigenetic data, and more . Patient-level pharmacogenetic data may ultimately be able to tell us the optimal drug regimen and optimal dosage of each drug to prescribe a given patient for anxiolysis, analgesia, anesthesia, and antiemetic prophylaxis based upon his or her unique genetic profile .…”

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confidence: 99%

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