Perioperative-, Recipient-, and Donor-Related Factors Affecting Delayed Graft Function in Kidney Transplantation

Aceto, Paola; Perilli, Valter; Luca, Emanuele De; Salerno, Maria Paola; Punzo, Giovanni; Ceaichisciuc, Ina; Cataldo, Andréa; Lai, Carlo; Citterio, Franco; Sollazzi, Liliana

doi:10.6002/ect.2018.0225

Cited by 11 publications

(16 citation statements)

References 24 publications

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“…Although numerous studies have assessed the causes of DGF, the results of these studies have not reached a consensus. In our study, prolonged CIT and WIT were most strongly associated with DGF, consistent with previous reports [11][12][13][14][15][16][17][18] . Additionally, longer duration of recipient pretransplant dialysis was likely to lead to DGF.…”

Section: Discussionsupporting

confidence: 93%

Predictors and One-year Outcomes of Patients with Delayed Graft Function after Deceased Donor Kidney Transplantation

Chen

Wang

Hou

et al. 2020

Preprint

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Objective:Delayed graft function (DGF) is closely associated with the use of marginal donated kidneys due to deficits during transplantation and in recipients. We aimed to predict the incidence of DGF and evaluate its effect on graft survival.Methods:This retrospective study on kidney transplantation was conducted from January 1, 2018, to May 31, 2019, in the Second Xiangya Hospital of Central South University. We classified recipients into training and validation cohorts and used data from the training cohort to analyze the predictors of DGF. A nomogram was then constructed to predict the likelihood of DGF based on these predictors.Results:The incidence rate of DGF is 24.73%. Binary logistic regression analysis showed correlations between the incidence of DGF and cold ischemic time (CIT), warm ischemic time (WIT), donor body mass index (BMI), duration of pretransplant dialysis, diabetic donor, primary cause of donor death, and terminal serum creatinine concentration. The internal accuracy of the nomogram was 85.78%. One-year graft survival rates were 100% and 94.74%, respectively, for the groups with and without DGF (P<0.05).Conclusion:The nomogram established in this study showed good accuracy in predicting DGF after deceased donor kidney transplantation; additionally, DGF decreased one-year graft survival.

show abstract

Section: Discussionsupporting

confidence: 93%

Predictors and One-year Outcomes of Patients with Delayed Graft Function after Deceased Donor Kidney Transplantation

Chen

Wang

Hou

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Numerous studies have assessed the causes of DGF, yet there is no consensus to date. In our study, prolonged CIT and WIT were most strongly associated with DGF, consistent with previous reports [20][21][22][23][24][25][26][27]. Additionally, a longer duration of recipient pretransplant dialysis was likely to lead to DGF.…”

Section: Discussionsupporting

confidence: 91%

Predictors and One-year Outcomes of Patients with Delayed Graft Function after Deceased Donor Kidney Transplantation

Chen

Wang

Song

et al. 2020

Preprint

View full text Add to dashboard Cite

Background:Delayed graft function (DGF) is closely associated with the use of marginal donated kidneys due to deficits during transplantation and in recipients. We aimed to predict the incidence of DGF and evaluate its effect on graft survival.Methods:This retrospective study on kidney transplantation was conducted from January 1, 2018, to December 31, 2019, at the Second Xiangya Hospital of Central South University. We classified recipients whose operations were performed in different years into training and validation cohorts and used data from the training cohort to analyze predictors of DGF. A nomogram was then constructed to predict the likelihood of DGF based on these predictors.Results:The incidence rate of DGF was 16.92%. Binary logistic regression analysis showed correlations between the incidence of DGF and cold ischemic time (CIT), warm ischemic time (WIT), terminal serum creatine (Scr) concentration,, duration of pretransplant dialysis, primary cause of donor death, and usage of LifePort . The internal accuracy of the nomogram was 83.12%. One-year graft survival rates were 93.59% and 99.74%, respectively, for the groups with and without DGF (P<0.05).Conclusion:The nomogram established in this study showed good accuracy in predicting DGF after deceased donor kidney transplantation; additionally, DGF decreased one-year graft survival.

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Section: Recipient Factorssupporting

confidence: 91%

Predictors and one-year outcomes of patients with delayed graft function after deceased donor kidney transplantation

et al. 2020

View full text Add to dashboard Cite

Background Delayed graft function (DGF) is closely associated with the use of marginal donated kidneys due to deficits during transplantation and in recipients. We aimed to predict the incidence of DGF and evaluate its effect on graft survival. Methods This retrospective study on kidney transplantation was conducted from January 1, 2018, to December 31, 2019, at the Second Xiangya Hospital of Central South University. We classified recipients whose operations were performed in different years into training and validation cohorts and used data from the training cohort to analyze predictors of DGF. A nomogram was then constructed to predict the likelihood of DGF based on these predictors. Results The incidence rate of DGF was 16.92%. Binary logistic regression analysis showed correlations between the incidence of DGF and cold ischemic time (CIT), warm ischemic time (WIT), terminal serum creatine (Scr) concentration, duration of pretransplant dialysis, primary cause of donor death, and usage of LifePort. The internal accuracy of the nomogram was 83.12%. One-year graft survival rates were 93.59 and 99.74%, respectively, for the groups with and without DGF (P < 0.05). Conclusion The nomogram established in this study showed good accuracy in predicting DGF after deceased donor kidney transplantation; additionally, DGF decreased one-year graft survival.

show abstract

Perioperative-, Recipient-, and Donor-Related Factors Affecting Delayed Graft Function in Kidney Transplantation

Cited by 11 publications

References 24 publications

Predictors and One-year Outcomes of Patients with Delayed Graft Function after Deceased Donor Kidney Transplantation

Predictors and One-year Outcomes of Patients with Delayed Graft Function after Deceased Donor Kidney Transplantation

Predictors and One-year Outcomes of Patients with Delayed Graft Function after Deceased Donor Kidney Transplantation

Predictors and one-year outcomes of patients with delayed graft function after deceased donor kidney transplantation

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