Perioperative Sleep Disorder: A Review

Lin, Dandan; Huang, Xiao; Sun, Yi; Wei, Changwei; Wu, Anshi

doi:10.3389/fmed.2021.640416

Cited by 30 publications

(20 citation statements)

References 96 publications

(113 reference statements)

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“…Risk factors of CPSP are diverse, including acute postsurgical pain, genetic susceptibility, preceding pain, age, sex, and psychosocial factors (e.g., perioperative sleep disorder, fear, and anxiety) [ 5 ]. Recent research has highlighted the negative influence of perioperative sleep deprivation (SD) on CPSP [ 6 ]. SD significantly causes hyperalgesia, and it further enhances pain facilitation [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Pretreatment of the ROS Inhibitor Phenyl-N-tert-butylnitrone Alleviates Sleep Deprivation-Induced Hyperalgesia by Suppressing Microglia Activation and NLRP3 Inflammasome Activity in the Spinal Dorsal Cord

et al. 2022

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Sleep deprivation, a common perioperative period health problem, causes ocular discomfort and affects postsurgical pain. However, the mechanism of sleep deprivation-induced increased pain sensitivity is elusive. This study aims to explore the role of ROS in sleep deprivation (SD)-induced hyperalgesia and the underlying mechanism. A 48-h continuous SD was performed prior to the hind paw incision pain modeling in mice. We measured ROS levels, microglial activation, DNA damage and protein levels of iNOS, NLRP3, p-P65 and P65 in mouse spinal dorsal cord. The involvement of ROS in SD-induced prolongation of postsurgical pain was further confirmed by intrathecal injection of ROS inhibitor, phenyl-N-tert-butylnitrone (PBN). Pretreatment of 48-h SD in mice significantly prolonged postsurgical pain recovery, manifesting as lowered paw withdrawal mechanical threshold and paw withdrawal thermal latency. It caused ROS increase and upregulation of iNOS on both Day 1 and 7 in mouse spinal dorsal cord. In addition, upregulation of NLRP3 and p-P65, microglial activation and DNA damage were observed in mice pretreated with 48-h SD prior to the incision. Notably, intrathecal injection of PBN significantly reversed the harmful effects of SD on postsurgical pain recovery, hyperalgesia, microglial activation and DNA damage via the NF-κB signaling pathway. Collectively, ROS increase is responsible for SD-induced hyperalgesia through activating microglial, triggering DNA damage and enhancing NLRP3 inflammasome activity in the spinal dorsal cord.

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Section: Introductionmentioning

confidence: 99%

Pretreatment of the ROS Inhibitor Phenyl-N-tert-butylnitrone Alleviates Sleep Deprivation-Induced Hyperalgesia by Suppressing Microglia Activation and NLRP3 Inflammasome Activity in the Spinal Dorsal Cord

et al. 2022

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“…Among currently used scales for assessing sleep quality, like the PSQI questionnaire, Insomnia Severity Index, Athens Insomnia Scale, Epworth Sleepiness Scale, and General Sleep Disturbance Scale, the most commonly used assessment is PSQI on account of high reliability and validity[ 22 ]. The PSQI contains 19 self-rated questions and 5 questions rated by the bed partner or roommate.…”

Section: Discussionmentioning

confidence: 99%

Improved Pittsburgh Sleep Quality Index scores on first postoperative night achieved by propofol anesthesia in patients undergoing ambulatory gynecologic surgery

Hu¹,

Chou²

2022

WJCC

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BACKGROUND Sleep disturbance on the first postoperative night commonly develops for patients after day surgeries. The choice of either total intravenous anesthesia by propofol or total inhalation anesthesia with sevoflurane has become an issue for preventing sleep disturbance. AIM To compare s leep quality on the first postoperative night for female patients after total intravenous anesthesia by propofol and total inhalation anesthesia with sevoflurane. METHODS We enrolled 61 American Society of Anesthesia (ASA) class I-II outpatients who underwent minor gynecologic surgeries by either propofol or sevoflurane anesthesia. Sleep quality of the very night was assessed by the Pittsburgh Sleep Quality Index (PSQI) on the next day, and PSQI scores were compared by the Wilcoxon signed-rank test and paired t -test pre-operatively and postoperatively. RESULTS For the propofol group, the mean postoperative global PSQI score (3.3 ± 1.3) was lower than the mean preoperative global PSQI score (4.9 ± 2.3) ( P < 0.001); for the sevoflurane group, the mean postoperative global PSQI score (6.5 ± 2.8) was higher than the mean preoperative global PSQI score (5.5 ± 3.2) ( P = 0.02). Eighty percent of patients receiving propofol anesthesia subjectively reported improved sleep quality, but only 17% of patients receiving sevoflurane anesthesia reported improved sleep quality. CONCLUSION Sleep quality assessed by the PSQI is better improved in ASA class I-II female patients receiving propofol anesthesia other than sevoflurane anesthesia for undergoing minor gynecologic surgeries.

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“…It is hypothesized that there are 10 variables related to postoperative sleep disturbance, and the required positive sample size is 100. Previous studies reported that the incidence of postoperative sleep disorders is 49.7%, and is even up to 95% in cardiac surgery [ 30 , 31 ]. We assume that if the incidence of sleep disorders is 60%, then 167 patients are required.…”

Section: Methodsmentioning

confidence: 99%

Exploration of Perioperative Sleep Disturbance in 208 Patients Undergoing Non-Cardiac Surgery: Protocol for a Prospective Cohort Study

et al. 2023

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Background:Sleep disorder is a common complication for postoperative patients, which can impact their recovery and prognosis. In the perioperative period of non-cardiac surgery, multiple factors can be involved in abnormal sleep in patients, including changes in sleep quality and quantity. Thus, the purpose of this study is to explore the incidence of postoperative sleep disturbance and related influencing factors in 208 patients undergoing non-cardiac surgery. Material/Methods:This is a single-center prospective cohort study including 208 eligible patients who will undergo non-cardiac surgery. All participants will implement the assessment and monitoring of perioperative sleep quality using the Pittsburgh Sleep Quality Index (PSQI) and a wearable electroencephalogram (EEG) sleep monitor on the night before surgery and on the first, third, and fifth nights after surgery (the first night is the day of surgery). Meanwhile, we will collect the patient's basic information, past history, and surgery-related data from the hospital electronic medical record and will perform follow-up before and after surgery. Results:The primary outcome is the occurrence of sleep disturbance on the first, third, and fifth nights after surgery. The secondary outcomes are the factors related to sleep disturbance and changes in sleep structure on the first, third, and fifth nights after surgery. Conclusions:This study will record the incidence of postoperative sleep disturbance, explore the risk factors of postoperative sleep disturbance, and clarify the change of postoperative sleep structure, which will provide ideas for clinicians to manage patients' sleep disturbance during the perioperative period.

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Perioperative Sleep Disorder: A Review

Cited by 30 publications

References 96 publications

Pretreatment of the ROS Inhibitor Phenyl-N-tert-butylnitrone Alleviates Sleep Deprivation-Induced Hyperalgesia by Suppressing Microglia Activation and NLRP3 Inflammasome Activity in the Spinal Dorsal Cord

Pretreatment of the ROS Inhibitor Phenyl-N-tert-butylnitrone Alleviates Sleep Deprivation-Induced Hyperalgesia by Suppressing Microglia Activation and NLRP3 Inflammasome Activity in the Spinal Dorsal Cord

Improved Pittsburgh Sleep Quality Index scores on first postoperative night achieved by propofol anesthesia in patients undergoing ambulatory gynecologic surgery

Exploration of Perioperative Sleep Disturbance in 208 Patients Undergoing Non-Cardiac Surgery: Protocol for a Prospective Cohort Study

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