Perioperative synbiotic therapy in elderly patients undergoing gastroenterological surgery: A prospective, randomized control trial

Okazaki, Mitsuyoshi; Matsukuma, Satoshi; Suto, Ryuichiro; Miyazaki, Keiko; Hidaka, Masaaki; Matsuo, Masatsugu; Noshima, Shinji; Zempo, Nobuya; Asahara, Takashi; Nomoto, Koji

doi:10.1016/j.nut.2013.03.015

Cited by 41 publications

(58 citation statements)

References 49 publications

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“…To reduce surgical complications, Okazaki et al (27) administered Lactobacillus casei and Bifidobacterium breve and obtained 12% of surgical complications compared to 36% in the control group. Tanaka et al (28) evaluated the impact of the administration of 1×10 8 …”

Section: Discussionmentioning

confidence: 99%

Probiotics as a preventive strategy for surgical infection in colorectal cancer patients: a systematic review and meta-analysis of randomized trials

Calaça¹,

Bezerra²,

Albuquerque³

et al. 2017

Transl. Gastroenterol. Hepatol.

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Background: Infection following abdominal surgery remains a major factor in morbidity among colorectal cancer (CRC) patients. Probiotic therapy has been suggested to improve the clinical and laboratory outcome of patients undergoing gastrointestinal surgery. The aim of this study was to investigate the efficacy of probiotic lactic acid bacteria in patients with CRC in the pre-and postoperative phases.Methods: Systematic database searches identified 1,080 related articles. However, only seven articles were selected according to the eligibility criteria for qualitative and quantitative evaluation.Results: Most of the reviewed articles presented satisfactory results related to the prevention of surgical inflammation in patients undergoing resection of CRC when using strains of Lactobacillus genus, predominantly.Conclusions: Probiotics are suggested to prevent surgical inflammation of CRC, at the same time that the combination of particular microorganisms administered is beneficial to the treatment and surgical recovery.

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Section: Discussionmentioning

confidence: 99%

Probiotics as a preventive strategy for surgical infection in colorectal cancer patients: a systematic review and meta-analysis of randomized trials

Calaça¹,

Bezerra²,

Albuquerque³

et al. 2017

Transl. Gastroenterol. Hepatol.

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“…Finally, 28 randomized controlled trials involving 2511 patients were included in this systematic review (Figure 1). 6 – 9 , 18 – 41 …”

Section: Resultsmentioning

confidence: 99%

Effect of Perioperative Probiotics and Synbiotics on Postoperative Infections After Gastrointestinal Surgery: A Systematic Review With Meta‐Analysis

Yang

Liu

et al. 2016

J Parenter Enteral Nutr

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“…Symbiotic supplementation in elderly have been conducted in various scenarios: inflammatory markers (17) ; intestinal polyamine concentrations (18) ; gut microbiota composition, metabolism, immunity and blood lipids levels (19) ; infectious complications after gastrointestinal surgeries (20) ; mental disorders and inflammation (21) .…”

Section: Effects Of Synbiotic Supplementation On Gut Functioning and mentioning

confidence: 99%

Effects of Synbiotic Supplementation on Gut Functioning and Systemic Inflammation of Community-Dwelling Elders - Secondary Analyses From a Randomized Clinical Trial

Neto

Chella

Rudnik

et al. 2020

Arq. Gastroenterol.

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BACKGROUND: Aging is a complex process marked by alterations on gut functioning and physiology, accompanied by an increase on the inflammatory status, leading to a scenario called “inflammaging”. OBJECTIVE: To evaluate the effects of a synbiotic substance on systemic inflammation, gut functioning of community-dwelling elders. METHODS: This is a secondary analysis from a randomized clinical trial, lasting 24 weeks, including 49 elders, distributed into two groups: SYN (n=25), which received a synbiotic substance (Frutooligossacaride 6g, Lactobacillus paracasei LPC-31 109 to 108 UFC, Lactobacillus rhamnosus HN001 109 to 108 UFC, Lactobacillus acidophilus NCFM 109 to 108 UFC e Bifidobacterium lactis HN019 109 to 108 UFC), or PLA (n=24), receiving placebo. The evaluations consisted of serum IL-10 e TNF-α (after overnight fasting), evaluation of chronic constipation (by Rome III Criteria) and faeces types (by Bristol Stool Form Scale). Data were compared before and after the supplementation time, and between groups. RESULTS: No significant differences were found between baseline and final values of serum inflammatory markers. Some subtle beneficial changes were observed in SYN, concerning both gut functioning and faeces types. CONCLUSION: From our data, synbiotic supplementation showed a subtle benefit in gut functioning in apparently healthy community-dwelling elders. Our findings can suggest that the benefits in healthy individuals were less expressive than the ones presented in studies with individuals previously diagnosed as dysbiosis. Future studies, comparing elders with and without gut dysbiosis can confirm our findings.

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Perioperative synbiotic therapy in elderly patients undergoing gastroenterological surgery: A prospective, randomized control trial

Cited by 41 publications

References 49 publications

Probiotics as a preventive strategy for surgical infection in colorectal cancer patients: a systematic review and meta-analysis of randomized trials

Probiotics as a preventive strategy for surgical infection in colorectal cancer patients: a systematic review and meta-analysis of randomized trials

Effect of Perioperative Probiotics and Synbiotics on Postoperative Infections After Gastrointestinal Surgery: A Systematic Review With Meta‐Analysis

Effects of Synbiotic Supplementation on Gut Functioning and Systemic Inflammation of Community-Dwelling Elders - Secondary Analyses From a Randomized Clinical Trial

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