Perioperative urinary heat shock protein 72 as an early marker of acute kidney injury in dogs

Kavkovsky, Anastasiya; Avital, Yochai; Aroch, Itamar; Segev, Gil; Shipov, Anna

doi:10.1016/j.vaa.2019.09.002

Cited by 5 publications

(6 citation statements)

References 38 publications

(42 reference statements)

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“…Since traditional markers of tubulopathy (eg, cylinduria and glucosuria) are insensitive, more sensitive urinary biomarkers of renal tubular cells can improve early recognition of tubulopathy, and potentially aid in predicting AKI and initiating timely therapy. Most veterinary studies tested urinary biomarkers in dogs with experimentally‐induced AKI, 10 or retrospectively enrolled dogs with overt AKI, but only few have reported their clinical utility for predicting AKI and death prospectively and longitudinally 15,30 …”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, that study enrolled dogs with overt AKI, thus precluding investigation of its predictive performance for AKI 14 . Recently, uHSP70/uCr was prospectively evaluated in 80 dogs undergoing elective or emergency surgery, and was significantly increased, while sCr significantly decreased postoperatively 15 . Furthermore, the proportion of dogs with elevated uHSP70/uCr increased with increase in their ASA status, which served as a surrogate marker of disease severity and anesthetic risk.…”

Section: Discussionmentioning

confidence: 99%

“…Most veterinary studies tested urinary biomarkers in dogs with experimentally‐induced AKI, 10 or retrospectively enrolled dogs with overt AKI, but only few have reported their clinical utility for predicting AKI and death prospectively and longitudinally. 15 , 30 …”

Section: Discussionmentioning

confidence: 99%

“…In dogs, uHSP72 has excellent diagnostic and prognostic performance in overt, azotemic AKI 14 . Furthermore, uHSP72 increases postoperatively in some dogs, especially in those with higher American Society of Anesthesiologists (ASA) status, and often in absence of any increase in sCr concentration 15 . Nevertheless, its predictive performance for AKI in nonazotemic, hospitalized dogs in general has not been investigated.…”

Section: Introductionmentioning

confidence: 99%

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Prospective evaluation of 5 urinary biomarkers as predictors of acute kidney injury in nonazotemic, hospitalized dogs

Nivy

Chaim

Hanael

et al. 2021

Veterinary Internal Medicne

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Background Early recognition of acute kidney injury (AKI) is hindered by current definitions and use of traditional, insensitive markers. Hypothesis/Objectives Urinary (u) activity of γ‐glutamyl transpeptidase (GGT) and alkaline phosphatase (ALP), and concentrations of heat‐shock protein 70 (HSP70) and interleukins (ILs) ‐6 and ‐18, are predictive biomarkers for AKI and survival. Animals Nonazotemic, hospitalized dogs (n = 118) and healthy controls (n = 20). Methods A prospective observational study. Nonazotemic dogs at risk of AKI were recruited and their urinary biomarker concentrations were measured at presentation. Serum creatinine (sCr) and symmetric dimethylarginine (sSDMA) were measured daily until discharge/death. Results The overall case fatality rate was 18.6%. Fifteen dogs (12.7%) developed AKI, which was associated with death (relative risk, 3.2; 95% confidence interval [CI], 1.57‐6.55). All 5 urinary biomarkers were significantly higher in hospitalized dogs compared to controls, with minimal overlap. uHSP70/uCr, uGGT/uCr, and uIL‐6/uCr at presentation were higher in dogs which later developed AKI. Areas under the receiver operator characteristic curve (AUROC) (95% CI) for the 3 biomarkers as predictors of AKI were 0.67 (0.51‐0.83), 0.68 (0.55‐0.81), and 0.78 (0.65‐0.91), respectively. When they were categorically classified as elevated/normal, each additional elevated biomarker increased the odds for AKI (OR, 2.83; 95% CI, 1.23‐6.52, P = .01). Agreement between sCr and sSDMA was poor (Cohen's kappa = .071). The AUROC of SDMA at presentation for AKI prediction was 0.73 (0.51‐0.95). Conclusions and Clinical Importance Kidney injury was common, irrespective of subsequent worsening of azotemia or death. The predictive value of individual urinary biomarkers was reduced by moderate sensitivities and specificities. SDMA showed moderate discriminatory utility for AKI prediction, and often displayed discordant results with sCr.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prospective evaluation of 5 urinary biomarkers as predictors of acute kidney injury in nonazotemic, hospitalized dogs

Nivy

Chaim

Hanael

et al. 2021

Veterinary Internal Medicne

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“…Moreover, uHSP72:uCr, which is urinary heat shock protein-72 could be another biomarker for the identification of CKD in cats and dogs. It was observed that the levels of uHSP72:uCr were increased in cats and dogs with CKD [16,19].…”

Section: Potential Biomarkers For the Detection Of Ckdmentioning

confidence: 99%

NMR-based metabolomics associated with chronic kidney disease in humans and animals: a one health perspective

et al. 2021

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Chronic kidney disease (CKD) is a renal dysfunction that can lead to high rates of mortality and morbidity, particularly when coupled with late diagnosis. CKD has become a major health problem due to its challenging detection at early stages when clear symptoms are yet to be presented. Thus, CKD is likely to be identified when the substantive conditions of the disease are manifest. In order to address the development of the disease and provide necessary treatments at the initial stage, the investigation of new biomarkers and metabolites associated with early detection of CKD are needed. Identified metabolites could be used to confirm the presence of the disease, obtain information on its mechanism and facilitate the development of novel pharmaceutical treatments. Such metabolites may be detected from biofluids and tissues using a range of analytical techniques. There are a number of metabolites that have been identified by mass spectrometry at high sensitivities, whilst the detection of metabolites directly from biofluids using NMR could present a more rapid way to expand our understanding of this disease. This review is focused on NMR-based metabolomics associated with CKD in humans and animals.

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Anesthetic process

Kushnir¹,

McKune²

2022

Small Animal Anesthesia Techniques

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Perioperative urinary heat shock protein 72 as an early marker of acute kidney injury in dogs

Cited by 5 publications

References 38 publications

Prospective evaluation of 5 urinary biomarkers as predictors of acute kidney injury in nonazotemic, hospitalized dogs

Prospective evaluation of 5 urinary biomarkers as predictors of acute kidney injury in nonazotemic, hospitalized dogs

NMR-based metabolomics associated with chronic kidney disease in humans and animals: a one health perspective

Anesthetic process

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