Perioperative Use of Cyproterone Acetate with Transurethral Resection of Large Prostate: Preliminary Results

Abstract

The perioperative use of CPA with M-TURP of a relatively large prostate may help in decreasing the perioperative bleeding and fluid absorption that usually take place during this procedure.

The effect of short-term use of finasteride versus cyproterone acetate on perioperative blood loss with monopolar transurethral resection of prostate

“…CPA reduced the microvessel density in prostatic tissue more than finasteride and both of them are better than control group, and this also is in accordance with that reported by Elgammal et al who reported that MVD is significantly reduced after CPA administration and Ozal et al who reported that MVD is significantly reduced after finasteride administration [8,19]. Also Hochberg et al [20] reported that suburethral prostatic MVD significantly decreased in patients with BPH taking finasteride.…”

“…Cyproterone acetate has been frequently used in treatment of cancer prostate; also many studies on patients with BPH demonstrated that it causes atrophy, an effect similar to the effect of castration [8].…”

“…The effect of preoperative use of cyproterone acetate before TURP was studied by Elgammal et al who support that the use of CPA decreases perioperative blood loss with TURP by affecting prostate vascularity decreasing the MVD of the prostate [8].…”

“…CPA has been widely used in the past for endocrine treatment of prostate cancer; evidence from studies of patients with BPH shows that CPA causes atrophy, an effect comparable to that caused by castration [7]. In addition, it has been also used for some non-oncological diseases that necessitate reduction of serum testosterone or its action, such as severe female hirsutism, hormone therapy for male-to-female transsexuals and precocious puberty [8].…”

“…Elgammal et al showed that CPA decreased the perioperative blood loss with TURP by decreasing the MVD of prostate [8].…”