Perioral Dermatitis

Rademaker, Marius

doi:10.1002/9781119142812.ch26

Harper's Textbook of Pediatric Dermatology 2019

DOI: 10.1002/9781119142812.ch26

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Perioral Dermatitis

Marius Rademaker¹

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2021

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Cited by 1 publication

(2 citation statements)

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“…A related inflammatory skin condition – perioral dermatitis – is frequently associated with the long‐term use of topical steroids on the face 3 . In fact, these two clinical entities (rosacea and perioral dermatitis) are histologically similar and considered by some clinicians to be variants of the same condition 4 . Together they represent cardinal examples of skin conditions that are initiated or worsened by steroids.…”

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“… 3 In fact, these two clinical entities (rosacea and perioral dermatitis) are histologically similar and considered by some clinicians to be variants of the same condition. 4 Together they represent cardinal examples of skin conditions that are initiated or worsened by steroids. However, the molecular mechanisms that underlie their atypical proinflammatory response to steroids is not well understood.…”

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confidence: 99%

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Glucocorticoids promote CCL20 expression in keratinocytes

et al. 2021

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Summary Background Glucocorticoids (GCs) are generally envisioned as immunosuppressive, but in conditions such as rosacea and perioral dermatitis they can lead to increased skin inflammation. In lung epithelia, GCs promote expression of the proinflammatory cytokine CCL20, which contributes to steroid‐resistant asthma. In the skin, CCL20 stimulates inflammation by recruiting T helper 17 T lymphocytes and dendritic cells, and is elevated in papulopustular rosacea. Objectives To understand if, and how, GCs affect CCL20 expression in human keratinocytes. CCL20 expression was assessed by quantitative reverse transcriptase polymerase chain reaction and enzyme‐linked immunosorbent assay. Methods Selective inhibition of candidate genes and signalling pathways was performed using RNA interference and chemical inhibitors. The binding of activated GC receptor to genomic DNA was determined by chromatin immunoprecipitation, and enhancer activity of genomic sequences was measured with a reporter assay. Results We found that GC treatment increased CCL20 expression in human keratinocytes and murine skin, both in the undisturbed state and with tumour necrosis factor‐α stimulation. GC repressed proinflammatory signalling pathways, including nuclear factor kappa B and p38/mitogen‐activated protein kinase, but these inhibitory effects were opposed by the direct binding of activated GC receptor to the CCL20 enhancer, promoting CCL20 expression. Conclusions Viewed together, these findings demonstrate a mechanism by which GCs induce expression of CCL20 in keratinocytes, which may contribute to the inflammation seen in steroid‐exacerbated skin conditions.

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confidence: 99%

Glucocorticoids promote CCL20 expression in keratinocytes

et al. 2021

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Perioral Dermatitis

Cited by 1 publication

References 48 publications

Glucocorticoids promote CCL20 expression in keratinocytes

Glucocorticoids promote CCL20 expression in keratinocytes

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