Periorbital Lipogranuloma Following Facial Autologous Fat Injections: Non-surgical Treatment

Seo, Ji Won; Sa, Ho-Seok

doi:10.1007/s00266-015-0554-0

Cited by 10 publications

(9 citation statements)

References 18 publications

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“…Research on the cryopreservation of fat is limited compared with the advances achieved in adipose regenerative medicine. Seo and Sa reported the results of facial autologous fat injection in 27 patients with periorbital lipogranuloma, of which 19 patients received cryopreserved fat [10].…”

Section: Discussionmentioning

confidence: 99%

“…Although cryopreservation of fat tissue has been studied extensively, the results remain controversial [6–8]. In addition to the impracticality of the highly demanding freezing procedure, cryopreservation of fat tissue can induce substantial fat necrosis and may lead to complications such as oil cysts, fat granuloma, and chronic inflammation [9, 10]. Adipocytes are vulnerable under stress conditions such as exposure to ischemia and freezing [11, 12].…”

Section: Introductionmentioning

confidence: 99%

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Mechanical process prior to cryopreservation of lipoaspirates maintains extracellular matrix integrity and cell viability: evaluation of the retention and regenerative potential of cryopreserved fat-derived product after fat grafting

Feng

Fanai

et al. 2019

Stem Cell Res Ther

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Background Cryopreservation of fat grafts facilitates reinjection for later use. However, low temperature and thawing can disrupt tissues and cause lipid leakage, which raises safety concerns. Here, we compared the cryopreservation potential of stromal vascular fraction (SVF) gel processed from lipoaspirate with that of fat. Methods Human SVF gel and fat were cryopreserved at − 20 °C without cryoprotectant for 1 month. Fresh SVF gel and fat were used as controls. Tissue viability, adipose-derived stem cell (ASC) function, and the extracellular content were evaluated. At 3 months after transplanting the specimens to immunocompromised mice subcutaneously, the grafts were examined for retention, tissue engraftment, and inflammatory levels. The regenerative effect of cryopreserved SVF gel was evaluated in a murine ischemic wound healing model. Results At 1 month, the cell death rate in the SVF gel group was 36 ± 2%. The survived ASCs not only could be isolated via explant culture but also preserved colony-forming and differentiation. However, prolonged cryopreservation exacerbated apoptosis. Assessment of recovered tissues showed that the morphology, cell viability, and extracellular protein enrichment were better in SVF gel-preserved tissues than in frozen fat. At 3 months after lipotransfer, the retention ability of 1-month cryopreserved fat was 41.1 ± 9% compared to that of 1-month cryopreserved SVF gel. Immunostaining results showed that adipose tissue regeneration and integrity in the 1-month cryopreserved SVF gel group were superior to those of the cryopreserved fat group. The cryopreserved SVF gel also accelerated healing of the ischemic wound, compared with cryopreserved fat. Conclusion Cryopreserved SVF gel maintained tissue integrity and cell viability and resulted in a better long-term retention rate than that of cryopreserved fat. Cryopreserved SVF gel also showed superior regenerative potential and improved ischemic wound healing.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mechanical process prior to cryopreservation of lipoaspirates maintains extracellular matrix integrity and cell viability: evaluation of the retention and regenerative potential of cryopreserved fat-derived product after fat grafting

Feng

Fanai

et al. 2019

Stem Cell Res Ther

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“…Twelve articles received a score of 4, with an excellent presentation of the reported cases. 10 13 14 15 16 17 18 19 20 21 22 23 Nineteen articles scored 3.5, 9 20 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 primarily due to a lack of confirmation by a dermatologist or cosmetic surgeon of the history and type of procedure done.…”

Section: Resultsmentioning

confidence: 99%

Clinical and radiographic features of facial cosmetic materials: A systematic review

et al. 2022

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Purpose The aim of this study was to systematically screen the literature for studies reporting cosmetic material in the oral and maxillofacial complex to shed light on the types of cosmetic materials, their radiographic appearance, and possible complications. Materials and Methods Five electronic databases were reviewed for eligible studies. The general search terms were “cosmetic,” “filler,” “face,” and “radiograph.” Demographics, material types, clinical and radiographic presentation, and complications were recorded. Results Thirty-one studies with 53 cases met the inclusion criteria. The mean age was 52.6±15.4 years with a 4 : 3 female-to-male ratio. The most common material was calcium hydroxyapatite (CaHa) (n=14, 26.4%), found incidentally. The materials were generally located within the upper cheek and zygoma (n=35, 66.0%), radiographically well-defined (n=44, 83%), and had no effects on the surrounding structures (n=27, 50.9%). The internal structure was radiopaque (calcification, hyperdensity) for gold wires, CaHa, bone implants, and secondary calcification or ossification. Outdated cosmetic materials or non-conservative techniques were infiltrative, had effects on the surrounding structures, and presented with clinical signs, symptoms, or complications. Conclusion Conventional radiography, cone-beam computed tomography, and multi-detector computed tomography are useful to differentiate several cosmetic materials. Their magnetic resonance imaging appearance was highly variable. The infrequent inclusion of cosmetic materials in the differential diagnosis implies that medical and dental specialists may be unfamiliar with the radiographic appearance of these materials in the face.

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“…However, several case reports and case series of granulomatous reactions to fat transfer in the face have been reported. Two of the largest retrospective case series, describing lipogranulomas in the eyelid, cheek, and forehead, were published by Seo and Sa 9 and Lee et al 10 …”

Section: Discussionmentioning

confidence: 99%

“…Seo and Sa 9 reviewed the outcomes of 27 patients with oral prednisone, intralesional steroid injection, surgery, observation, or combination therapy with the end point of full resolution. Steroids were found to be 70% effective (21 patients), surgery was 100% effective (2 patients), and observation was 50% effective (4 patients).…”

Section: Discussionmentioning

confidence: 99%

Granulomatous reaction to autologous gluteal fat transfer

2019

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Periorbital Lipogranuloma Following Facial Autologous Fat Injections: Non-surgical Treatment

Abstract: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

Cited by 10 publications

References 18 publications

Mechanical process prior to cryopreservation of lipoaspirates maintains extracellular matrix integrity and cell viability: evaluation of the retention and regenerative potential of cryopreserved fat-derived product after fat grafting

Mechanical process prior to cryopreservation of lipoaspirates maintains extracellular matrix integrity and cell viability: evaluation of the retention and regenerative potential of cryopreserved fat-derived product after fat grafting

Clinical and radiographic features of facial cosmetic materials: A systematic review

Granulomatous reaction to autologous gluteal fat transfer

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