Periorbital Oedema and Erythema as a Manifestation of Discoid Lupus erythematosus

Braun, Ralph P.; French, Lars E.; Massouyé, I.; Saurat, J.‐H.

doi:10.1159/000063915

Cited by 21 publications

(21 citation statements)

References 12 publications

(12 reference statements)

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“…23 In our cases, the absence of the classic manifestations of dermatomyositis, supported Those patients who have been reported with cutaneous lupus erythematosus involving the eyelids usually have a rapid response to antimalarial treatment. 9,12,13,15,16 However, our cases showed an unexpected poor response to antimalarial therapy but were successfully treated with azathioprine. This drug should be considered as an alternative form of treatment for those cases of periorbital mucinosis associated with lupus erythematosus.…”

Section: Discussionmentioning

confidence: 76%

“…Previously, similar cases have been reported. 12,13 As a rule, periorbital involvement occurs in the context of a preexisting diagnosis of lupus erythematosus (cases 1 and 2) and, rarely, may be its initial manifestation (case 3). Histopathologic examination of those periorbital lesions reported in the literature have shown changes consistent with chronic DLE 15 and less commonly with lupus panniculitis 14 and lupus erythematosus tumidus.…”

Section: Discussionmentioning

confidence: 99%

“…2,4,[7][8][9][10] Papulonodular mucinosis, also known as cutaneous lupus mucinosis, is a wellknown example of this. 4,7,11 Periorbital swelling secondary to dermal mucin deposition has been described in lupus erythematosus [12][13][14][15][16][17] ; however, it is not widely recognized as one of its cutaneous manifestations. We report a case series of periorbital mucinosis occurring in association with other cutaneous manifestations of lupus erythematosus.…”

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confidence: 99%

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Periorbital mucinosis: A variant of cutaneous lupus erythematosus?

Morales-Burgos

Sánchez

Gonzalez-Chávez

et al. 2010

Journal of the American Academy of Dermatology

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Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Periorbital mucinosis: A variant of cutaneous lupus erythematosus?

Morales-Burgos

Sánchez

Gonzalez-Chávez

et al. 2010

Journal of the American Academy of Dermatology

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“…Systemic lupus erythematosus as well as discoid lupus also should be considered in the differential [41][42][43][44][45]46 && , 47,48]. Researchers have proposed various theories regarding the cause of periorbital edema in lupus, including increased vascular permeability due to vasculitis, angioedema related to C1 deficiency, and protein deficiency due to nephrotic syndrome [47].…”

Section: Key Pointsmentioning

confidence: 99%

Periorbital edema

Carter

Allen

2012

Current Opinion in Ophthalmology

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“…6 Descriptions of imaging findings of LP are very scarce in the literature. CT scans of LEP showing periorbital edema 9 and increased attenuation surrounding the submandibular glands suggesting inflammation 10 have been reported, but there is no detailed imaging assessment of a LEP case in the literature, to the best of our knowledge. We analyzed the CT scan of our biopsy-proved LP case with the aid of 3D reconstructions of facial soft tissues.…”

Section: Case Reportmentioning

confidence: 99%

CT Imaging of Head and Neck Lupus Panniculitis

Vattoth

Curé²

2008

AJNR Am J Neuroradiol

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SUMMARY:Lupus panniculitis (LP) or lupus erythematosus profundus (LEP) is a lupus-associated dermatologic condition predominantly affecting young to middle-aged women in which the deep dermis and subcutaneous fat are mainly involved. The lesions are usually located on the forehead, cheeks, proximal aspect of the limbs, and buttocks, though cases have occasionally been reported with orbital, breast, and salivary gland involvement. Descriptions of imaging findings of LP are very scarce in the literature. We describe the CT scan imaging features of the case of a patient with head and neck LP. Lupus panniculitis (LP) is a very rare condition the imaging features of which are extremely scarce in the literature. We describe the CT scan imaging features of this rare disease entity in a patient. Case ReportA 28-year-old African American woman developed tender indurated lesions on the left arm and in the right face, extending from the parotid area around the angle of the jaw toward the chin. Two years previously, biopsy results of an indurated area on her face revealed no evidence of a neoplasm. She had been previously diagnosed with systemic lupus erythematosus (SLE) when she was found to have positive antinuclear antibody results in the context of a pregnancy ending in a stillbirth.Biopsy results of the lesion on her arm revealed panniculitis. It was recommended that she initiate treatment with steroids in combination with mycophenolate for lupus panniculitis. After 2 months, she experienced swelling of the bilateral neck. On physical examination, the lesion in the area of the right parotid was unchanged. There were new subcutaneous nodules in the neck bilaterally and in the submental area. The skin overlying these nodules was fixed to them. There was no palpable adenopathy.A contrast-enhanced CT scan of the neck demonstrated diffuse, superficial soft tissue infiltration of the right masticator space fat, extending into the fat overlying the anterior and lateral margins of the parotid gland. The lesion was both superficial and deep to the platysma muscle. There was extension into the posterior buccal space fat (Fig 1). The soft tissue infiltration lay superficial to both the masseter and temporalis muscles. The fat plane between the muscles was also ill defined. The right parotid duct was within the lesion (Fig 2). The process extended inferiorly into the right submandibular space, infiltrating the fat plane surrounding the right submandibular gland (Fig 3). The lesion produced an indrawing, cicatrizing effect rather than an outward bulge, which was illustrated on 3D surface-rendered images of the face (Fig 4). There was no adjacent osseous abnormality.There were mildly enlarged right intraparotid and level II lymph nodes and scattered bilateral shotty cervical lymph nodes, more prominent on the right side. The left parotid and submandibular salivary glands appeared normal. Extranodal lymphoid tissue in the Waldeyer ring and thyroid gland also appeared normal. Discussion LP is a rare skin condition, the clinical findin...

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Periorbital Oedema and Erythema as a Manifestation of Discoid Lupus erythematosus

Cited by 21 publications

References 12 publications

Periorbital mucinosis: A variant of cutaneous lupus erythematosus?

Periorbital mucinosis: A variant of cutaneous lupus erythematosus?

Periorbital edema

CT Imaging of Head and Neck Lupus Panniculitis

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