Periosteum and development of the tissue-engineered periosteum for guided bone regeneration

Zhang, Wentao; Wang, Naiguo; Yang, Ming; Sun, Tianze; Zhang, Jing; Zhao, Yantao; Huo, Na; Li, Zhonghai

doi:10.1016/j.jot.2022.01.002

Cited by 93 publications

(78 citation statements)

References 101 publications

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“…The most widely studied natural polymer materials are polysaccharide polymers and polypeptide polymers, such as chitosan and collagen membranes which are widely used as bone-healing materials [15][16][17]. However, natural biopolymers lack mechanical properties and do not meet the requirements for temporary mechanical substitution of periosteum tissue.…”

Section: Introductionmentioning

confidence: 99%

Enhanced Silk Fibroin/Sericin Composite Film: Preparation, Mechanical Properties and Mineralization Activity

Tian

Zhang

et al. 2022

Polymers

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The periosteum plays an important role in bone formation and reconstruction. One of the reasons for the high failure rate of bone transplantation is the absence of the periosteum. Silk fibroin (SF) and silk sericin (SS) have excellent biocompatibility and physicochemical properties, which have amazing application prospects in bone tissue engineering, but lacked mechanical properties. We developed a series of SF/SS composite films with improved mechanical properties using boiling water degumming, which caused little damage to SF molecular chains to retain larger molecules. The Fourier transform infrared spectroscopy and X-ray diffraction results showed that there were more β-sheets in SF/SS films than in Na2CO3 degummed SF film, resulting in significantly improved breaking strength and toughness of the composite films, which were increased by approximately 1.3 and 1.7 times, respectively. The mineralization results showed that the hydroxyapatite (HAp) deposition rate on SF/SS composite films was faster than that on SF film. The SF/SS composite films effectively regulated the nucleation, growth and aggregation of HAp-like minerals, and the presence of SS accelerated the early mineralization of SF-based materials. These composite films may be promising biomaterials in the repair and regeneration of periosteum.

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Section: Introductionmentioning

confidence: 99%

Enhanced Silk Fibroin/Sericin Composite Film: Preparation, Mechanical Properties and Mineralization Activity

Tian

Zhang

et al. 2022

Polymers

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“…These biomimicking periostea had unique advantages and had promising application prospects [ 44 ]. In addition, the other review summarized the importance of periosteum and summarized the advantages and disadvantages of different tissue engineering methods for construction of tissue-engineered periosteum [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

Construction of biomimetic cell-sheet-engineered periosteum with a double cell sheet to repair calvarial defects of rats

Zhang¹,

Huang²,

Wang³

et al. 2023

Journal of Orthopaedic Translation

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“…Simultaneously, osteoblasts, differentiated from BMSCs, deposit mineralized extracellular matrix and eventually reconstruct the Haversian system. [14] Alexander et al [15] were the first to reveal the role of macrophages in intramembranous ossification in a model of tibial injury. Macrophages are closely associated with osteoblast activity during the woven bone deposition at defective sites.…”

Section: Bone Healing Processmentioning

confidence: 99%

Bone Repair Biomaterials: A Perspective from Immunomodulation

Wang

Zhang

Yan

et al. 2022

Adv Funct Materials

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With an increasingly aging society, bone defects and fractures have become significant threats to human health and quality of life. Currently, autologous and allogeneic bone grafts remain the "gold standard" for the clinical treatment of bone repair. However, bone transplantation is still clinically insufficient, owing to its substantial limitations, such as graft rejection, donor functional defects, and risk of infection. Therefore, a variety of biomaterials have been developed to facilitate bone repair. With the advancement of bone tissue engineering, the focus of research has transitioned from bioinert to bioactive biomaterials. However, many biomaterials have not achieved satisfactory therapeutic effects. In recent years, advancements in osteoimmunology have revealed that the immune system, of which macrophages are critical components, plays an essential regulatory role in bone regeneration. In this review, the role of macrophages in bone healing is explored and recent developments in biomaterials that promote bone regeneration by modulating macrophage polarization and improving the osteoimmune microenvironment are reviewed. This review provides a reference for the development and clinical application of bone repair biomaterials from the immunomodulation perspective.

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Periosteum and development of the tissue-engineered periosteum for guided bone regeneration

Cited by 93 publications

References 101 publications

Enhanced Silk Fibroin/Sericin Composite Film: Preparation, Mechanical Properties and Mineralization Activity

Enhanced Silk Fibroin/Sericin Composite Film: Preparation, Mechanical Properties and Mineralization Activity

Construction of biomimetic cell-sheet-engineered periosteum with a double cell sheet to repair calvarial defects of rats

Bone Repair Biomaterials: A Perspective from Immunomodulation

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