2023
DOI: 10.1038/s41598-023-48485-8
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Periostin facilitates ovarian cancer recurrence by enhancing cancer stemness

Zhiqing Huang,
Olivia Byrd,
Sarah Tan
et al.

Abstract: The lethality of epithelial ovarian cancer (OC) is largely due to a high rate of recurrence and development of chemoresistance, which requires synergy between cancer cells and the tumor microenvironment (TME) and is thought to involve cancer stem cells. Our analysis of gene expression microarray data from paired primary and recurrent OC tissues revealed significantly elevated expression of the gene encoding periostin (POSTN) in recurrent OC compared to matched primary tumors (p = 0.015). Secreted POSTN plays a… Show more

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