Periostin in vitreoretinal diseases

Nakama, Takahito; Ishikawa, Keijiro; Nakao, Shintaro; Sonoda, Koh Hei; Ishibashi, Tatsuro

doi:10.1007/s00018-017-2651-5

Cited by 15 publications

(7 citation statements)

References 62 publications

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“…Periostin (POSTN) is a Fasciclin family stromal cell protein [ 25 ] that is believed to initiate cell proliferation, migration and epithelial-to-mesenchymal transformation by interacting with several integrins, including αVβ3, αVβ5 and α6β4 [ 26 , 27 ]. Our study found POSTN to be significantly expressed in fibroblasts.…”

Section: Discussionmentioning

confidence: 99%

The integrated transcriptome bioinformatics analysis identifies key genes and cellular components for proliferative diabetic retinopathy

et al. 2022

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Proliferative Diabetic Retinopathy (PDR) is a chronic complication of Diabetes and the main cause of blindness among the world’s working population at present. While there have been many studies on the pathogenesis of PDR, its intrinsic molecular mechanisms have not yet been fully elucidated. In recent years, several studies have employed bulk RNA-sequencing (RNA-seq) and single-cell RNA sequencing (scRNA-seq) to profile differentially expressed genes (DEGs) and cellular components associated with PDR. This study adds to this expanding body of work by identifying PDR’s target genes and cellular components by conducting an integrated transcriptome bioinformatics analysis. This study integrately examined two public bulk RNA-seq datasets(including 11 PDR patients and 7 controls) and one single-cell RNA-seq datasets(including 5 PDR patients) of Fibro (Vascular) Membranes (FVMs) from PDR patients and control. A total of 176 genes were identified as DEGs between PDR patients and control among both bulk RNA-seq datasets. Based on these DEGs, 14 proteins were identified in the protein overlap within the significant ligand-receptor interactions of retinal FVMs and Protein-Protein Interaction (PPI) network, three of which were associated with PDR (CD44, ICAM1, POSTN), and POSTN might act as key ligand. This finding may provide novel gene signatures and therapeutic targets for PDR.

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Section: Discussionmentioning

confidence: 99%

The integrated transcriptome bioinformatics analysis identifies key genes and cellular components for proliferative diabetic retinopathy

et al. 2022

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“…Its highest expression, however, is found in ERMs associated with PDR. Similar to osteonectin, periostin has been shown within ERM cells [ 56 ]. Proteomic profiling did not detect thus protein in iERMs [ 13 ].…”

Section: Ecm Components Of Iermsmentioning

confidence: 99%

Untangling the Extracellular Matrix of Idiopathic Epiretinal Membrane: A Path Winding among Structure, Interactomics and Translational Medicine

Bianchi

Altera

Barone

et al. 2022

Cells

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Idiopathic epiretinal membranes (iERMs) are fibrocellular sheets of tissue that develop at the vitreoretinal interface. The iERMs consist of cells and an extracellular matrix (ECM) formed by a complex array of structural proteins and a large number of proteins that regulate cell–matrix interaction, matrix deposition and remodelling. Many components of the ECM tend to produce a layered pattern that can influence the tractional properties of the membranes. We applied a bioinformatics approach on a list of proteins previously identified with an MS-based proteomic analysis on samples of iERM to report the interactome of some key proteins. The performed pathway analysis highlights interactions occurring among ECM molecules, their cell receptors and intra- or extracellular proteins that may play a role in matrix biology in this special context. In particular, integrin β1, cathepsin B, epidermal growth factor receptor, protein-glutamine gamma-glutamyltransferase 2 and prolow-density lipoprotein receptor-related protein 1 are key hubs in the outlined protein–protein cross-talks. A section on the biomarkers that can be found in the vitreous humor of patients affected by iERM and that can modulate matrix deposition is also presented. Finally, translational medicine in iERM treatment has been summed up taking stock of the techniques that have been proposed for pharmacologic vitreolysis.

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“…24 The development of PVR subretinal and epiretinal membranes is associated with vitreal accumulation of inflammatory cells, 25 including a significant elevation CD163/CD206expressing M2 macrophages. [26][27][28] Microglia, which regulate macrophage infiltration, proliferate and infiltrate through the retina and into the subretinal space within days of detachment. 29,30 peritoneal macrophages injected into the vitreous of the rabbit trans-differentiate into fibroblast-like cells and initiate intraretinal fibrosis similar to that seen in PVR.…”

Section: Inflammatory Phasementioning

confidence: 99%

“…Periostin is a fibroblast-derived matricellular mitogenic protein that stimulates EMT in cancer cells, accelerates cutaneous wound healing by activating fibroblasts 184,185 and causes inflammatory chemotaxis of TH2 cells and M2 macrophages by inducing cytokine production. 186,187 In patients with PVR, vitreal periostin levels are elevated along with high periostin expression in PVR membranes, 27 and the protein is produced in vitro by RPE cells that undergo TGFβ 2 -induced EMT. 106 These findings provide little support that periostin is likely to be useful as a predictive PVR molecular biomarker.…”

Section: Periostinmentioning

confidence: 99%

Inflammatory and Fibrogenic Factors in Proliferative Vitreoretinopathy Development

Chaudhary

Scott²,

Wallace

et al. 2020

Trans. Vis. Sci. Tech.

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Citation: Chaudhary R, Scott RAH, Wallace G, Berry M, Logan A, Blanch RJ. Inflammatory and fibrogenic factors in proliferative vitreoretinopathy development. Trans Vis Sci Tech. 2020;9(3):23, https://doi.org/10.1167/tvst.9.3.23Purpose: Proliferative vitreoretinopathy (PVR) occurs in 5%-10% of rhegmatogenous retinal detachment cases and is the principle cause for failure of retinal reattachment surgery. Although there are a number of surgical adjunctive agents available for preventing the development of PVR, all have limited efficacy. Discovering predictive molecular biomarkers to determine the probability of PVR development after retinal reattachment surgery will allow better patient stratification for more targeted drug evaluations.Methods: Narrative literature review. Results:We provide a summary of the inflammatory and fibrogenic factors found in ocular fluid samples during the development of retinal detachment and PVR and discuss their possible use as molecular PVR predictive biomarkers. Conclusions:Studies monitoring the levels of the above factors have found that few if any have predictive biomarker value, suggesting that widening the phenotype of potential factors and a combinatorial approach are required to determine predictive biomarkers for PVR.Translational Relevance: The identification of relevant biomarkers relies on an understanding of disease signaling pathways derived from basic science research. We discuss the extent to which those molecules identified as biomarkers and predictors of PVR relate to disease pathogenesis and could function as useful disease predictors.

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Periostin in vitreoretinal diseases

Cited by 15 publications

References 62 publications

The integrated transcriptome bioinformatics analysis identifies key genes and cellular components for proliferative diabetic retinopathy

The integrated transcriptome bioinformatics analysis identifies key genes and cellular components for proliferative diabetic retinopathy

Untangling the Extracellular Matrix of Idiopathic Epiretinal Membrane: A Path Winding among Structure, Interactomics and Translational Medicine

Inflammatory and Fibrogenic Factors in Proliferative Vitreoretinopathy Development

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