Peripapillary Retinal Nerve Fiber Layer Thickness in Children with Iron Deficiency Anemia

Türkyılmaz, Kemal; Öner, Veysi; Özkasap, Serdar; Şekeryapan, Berrak; Dereci, Selim; Durmuş, Mustafa

doi:10.5301/ejo.5000206

Cited by 35 publications

(24 citation statements)

References 27 publications

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“…In contrast, children with iron deficiency anaemia have been found to have lower average, superior and inferior RNFL thicknesses compared with controls. 7 A further study evaluating RNFL thicknesses in children with thalassaemia major or iron deficiency anaemia showed that RNFL thicknesses were decreased in all quadrants in children with thalassemia major, but in the inferior quadrant only in children with iron deficiency anemia. 8 The inconsistencies between these studies and our own may be a result of differences in the study populations.…”

Section: Discussionmentioning

confidence: 97%

“…5 The spectral domain OCT technique provides faster acquisition, better resolution and improved imaging of retinal morphology than traditional OCT. 6 In children with thalassaemia major and/ or iron deficiency anaemia, OCT studies found that RNFL thicknesses decreased, relative to reduced haemoglobin and ferritin concentrations. 7,8 To the best of our knowledge, RNFL thickness in adult women with iron deficiency anaemia has not been studied. The aim of the present study, therefore, was to evaluate RNFL thickness in adult women with iron deficiency anaemia, and in age-and sex-matched healthy control subjects.…”

Section: Introductionmentioning

confidence: 99%

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Peripapillary retinal nerve fibre layer thickness in women with iron deficiency anaemia

et al. 2014

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Objective: To evaluate peripapillary retinal nerve fibre layer (RNFL) thickness in adult women with iron deficiency anaemia and healthy control subjects. Methods: Women with iron deficiency anaemia and age-and sex-matched healthy control subjects were sequentially recruited and underwent detailed ophthalmic examination, including spectral-domain optical coherence tomography (OCT). Serum haemoglobin (Hb), iron and ferritin concentrations, total iron-binding capacity (TIBC) and mean corpuscular volume were determined. Results: Peripapillary RNFL thicknesses in the nasal and inferior quadrants were significantly smaller in patients (n ¼ 40) than in controls (n ¼ 40). In the patient group, there were significant correlations between inferior quadrant RNFL thickness and Hb, and between nasal quadrant RNFL thickness and serum iron and ferritin concentrations, and TIBC. Conclusion: Iron deficiency anaemia reduces RNFL thickness in adult women. KeywordsIron deficiency anaemia, adult women, peripapillary retinal nerve fibre layer, spectral-domain optical coherence tomography Date

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Peripapillary retinal nerve fibre layer thickness in women with iron deficiency anaemia

et al. 2014

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“…This finding was consistent with previous study. 10 These results suggest that a decreased hemoglobin level is associated with RNFL thinning and ganglion cell loss. However, glaucomatous optic disc cupping or notching in these patients was not observed.…”

Section: Discussionmentioning

confidence: 80%

“…The association between ischemic injury and ganglion cell loss has been investigated, 9 but the association between anemia and ganglion cell loss has not been examined. Turkyilmaz et al 10 reported that peripapillary retinal nerve fiber layer (RNFL) thickness was decreased in children with iron deficiency anemia, and RNFL thickness was significantly correlated with hemoglobin levels. To investigate the association between chronic anemia and ischemic optic neuropathy, investigation of RNFL profile in patients with hematologic malignancy would be ideal because these patients have their hemoglobin level measured often, and they often have a history of severe anemia during their treatment course.…”

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confidence: 99%

Retinal Nerve Fiber Layer Thickness is Decreased in Patients With Hematologic Malignancy

Han

Kim

Yoo

et al. 2016

Journal of Glaucoma

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“…And there was statistically significant correlation between mean RNFL, upper, lower, and temporal quadrant RNFL thickness and average values of hemoglobin. [19] Further study by Aksoy et al to evaluate RNFL thickness in children with thalassemia major and children with iron deficiency anemia, detect that RNFL thickness was decreased in inferior quadrant in IDA group and there was positive correlation between RNFL thickness and hemoglobin level. While in thalassemia major group, RNFL was decreased in all four quadrants compared to the control and IDA group.…”

Section: Discussion:-mentioning

confidence: 99%

Iron Deficiency Anemia as Risk Factor for Thinning of Peripapillary Retinal Nerve Fiber Layer Thickness.

Eltohamy.¹

2016

IJAR

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peripapillary retinal nerve fiber layer thickness ,Iron deficiency anemia, spectral domain optical coherence tomography, Purpose:-To compare thickness of peripapillary retinal nerve fiber layer (RNFL) in adult females having iron deficiency anemia (IDA) with age matched healthy control females by using spectral domain optical coherence tomography (OCT). Materials and Methods:-The study was conducted upon 30 adult female patients who had IDA (hemoglobin <12 g/dl, serum iron <50 μg/dl mean corpuscular volume <80 fl/ red cell) and 30 age matched healthy control females .complete ophthalmic examination (assessment of refraction and best corrected visual acuity ,intraocular pressure (IOP) measurement by Goldmannapplanation tonometry and fundus examination with C/D ratio assessment).Measurement of peripapillary retinal nerve fiber layer thickness by spectral domain optical coherence tomography . Blood analysis for hemoglobin, serum iron and mean corpuscular volume. Results:-Mean age of 30 adult anemic female patients was 33.57 ± 7.48 (range, 20-47) years, and of 30 healthy control females was 33.77 ± 6.32 (range, 22-46) years (P = 0.87). The mean RNFL thickness in anemic female patients was 89.5 ± 2.014, and in healthy control females was 94.22 ± 1.486 (P = 0.000026). The mean of inferior quadrant RNFL thicknesses of anemic female patients was 118.83 ± 2.75, and in healthy control females was 124.47 ± 1.93 (P = 0.000032). The mean of superior quadrant RNFL thicknesses of anemic female patients was 109.83 ± 2.3, and in healthy control females was 114.47 ± 1.7 (P = 0.00043). The mean of nasal quadrant RNFL thicknesses of anemic female patients was 69.4 ± 1.81, and in healthy control females was 73.7 ± 1.7 (P = 0.000028). The mean of temporal quadrant RNFL thicknesses of anemic female patients was 59.93 ± 1.95, and in healthy control females was 64.3 ± 1.7 (P = 0.00053). There was positive correlation between mean RNFL thickness and hemoglobin (r1 = 0.537, p1=0.002) and iron (r 2= 0.328, p2=0.005). Conclusions:-There is statically significant reduction of the thickness of peripapillary RNFL thickness measured by OCT in adult female patients with IDA compared to healthy control females. It may have a great impact on assessment of many diseases as glaucoma and neuroophthalmological disorder.

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Peripapillary Retinal Nerve Fiber Layer Thickness in Children with Iron Deficiency Anemia

Cited by 35 publications

References 27 publications

Peripapillary retinal nerve fibre layer thickness in women with iron deficiency anaemia

Peripapillary retinal nerve fibre layer thickness in women with iron deficiency anaemia

Retinal Nerve Fiber Layer Thickness is Decreased in Patients With Hematologic Malignancy

Iron Deficiency Anemia as Risk Factor for Thinning of Peripapillary Retinal Nerve Fiber Layer Thickness.

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