Peripapillary retinal nerve fiber layer thickness in patients with unilateral retinal vein occlusion

Ahn, Jin-Hee; Hwang, Duck Jin

doi:10.1038/s41598-021-97693-7

Cited by 6 publications

(9 citation statements)

References 33 publications

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“…Our result showed that peripapillary retinal nerve fiber layer (pRNFL) will most probably decrease after venous occlusions, showing an optic nerve damage, taking into consideration the fact that affected eyes presented a significant decrease in evolution of the pRNFL in comparison with the unaffected eyes. Similar results have been described by Ahn J et al in 2021 [ 12 ]. Some authors believe that retinal nerve fiber layer thinning should be considered the “natural course after branch retinal vein occlusions” [ 13 ], meanwhile others tried to underline that “optic disc swelling can cause difficulties in evaluating ONH parameters” [ 14 ].…”

Section: Discussionsupporting

confidence: 92%

Retinal vein occlusions associated or complicated with glaucoma. Aspects of prediction and paths of progression

Darabus

Pac

Munteanu

2023

rjo

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Section: Discussionsupporting

confidence: 92%

Retinal vein occlusions associated or complicated with glaucoma. Aspects of prediction and paths of progression

Darabus

Pac

Munteanu

2023

rjo

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“…Previously, significant decreases in thickness in the nerve fiber layer (NFL) and inner plexiform layer (IPL) in BRVO patients has been reported. 43 – 45 In general apoptosis and pyknosis were increased in the bevacizumab-treated retinas compared to the TA-treated retinas, and our hypothesis is that this increase is due to the blockage of VEGF which reduces neuroprotection. Greater degrees of change were seen in eyes treated with bevacizumab, which is a direct VEGF antagonist.…”

Section: Discussionmentioning

confidence: 73%

Inner Retinal Changes in Acute Experimental BRVO Treated With Bevacizumab or Triamcinolone Acetonide

McAllister

Vijayasekaran

Bhikoo

et al. 2023

Trans. Vis. Sci. Tech.

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Purpose Apoptosis is a key process in neural degeneration associated with retinal vascular diseases. Vascular endothelial growth factor (VEGF) antagonists, including bevacizumab, are used to treat macular edema in these diseases. As VEGF has a critical role in the preservation of retinal neuronal cells, this study investigates the effects of bevacizumab on neural damage in a pig model of branch retinal vein occlusion (BRVO) and compares it with triamcinolone acetonide (TA) which is reported to possess neuroprotective properties. Methods Thirty-six pigs had a photothrombotic BRVO in both eyes. Six pigs were injected with bevacizumab in one eye and TA in the fellow eye, then they were sacrificed, the eyes enucleated, and retinas processed at 2, 6, 10, and 20 days, respectively, together with three pigs (six eyes) BRVO only and three normal pigs (six eyes). Neuronal degeneration (apoptosis) and associated inner retinal changes were determined by terminal deoxyynuclotidyl transferase dUTP nick-end labeling (TUNEL), histology, and immunohistochemistry for macrophages. Results TUNEL labeling showed significantly higher apoptosis rates in the ganglion cell layer (GCL) and the inner nuclear layer (INL) in the bevacizumab-treated compared with the TA-treated retinas at 2, 10, and 20 day time points after occlusion ( P < 0.05). Pyknotic cells were significantly higher in the GCL in bevacizumab-treated eyes at 6, 10, and 20 days and in the INL at 2 days compared to TA-treated retinas ( P < 0.05). Macrophage infiltration was seen at all time points in both untreated and treated retinas with an absence of significance between bevacizumab- and TA-treated retinas ( P > 0.05). Conclusions Neurodegeneration in the BRVO acute phase is exacerbated by current standard treatments for BRVO. These results may have implications for the timing and treatment type. Translational Relevance In the acute phase of BRVO, VEGF suppression with bevacizumab and to a lesser extent with triamcinolone exacerbates apoptosis in the inner retinal layers, which has implications for both the timing and choice of treatment.

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“…35 Fibrous intimal thickening of artery-compressing veins that progresses chronically increases the risk of thrombogenesis and contributes to the development of retinal vein occlusion. 36 The measurement of these changes through retinal vessels has a high diagnostic value for confirming the progression of MMD. 2 Generally, MRA has been widely used in the diagnosis and staging of MMD.…”

Section: Discussionmentioning

confidence: 99%

Screening of Moyamoya Disease From Retinal Photographs: Development and Validation of Deep Learning Algorithms

Hong,

Yoon,

Shim

et al. 2024

Stroke

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BACKGROUND: Moyamoya disease (MMD) is a rare and complex pathological condition characterized by an abnormal collateral circulation network in the basal brain. The diagnosis of MMD and its progression is unpredictable and influenced by many factors. MMD can affect the blood vessels supplying the eyes, resulting in a range of ocular symptoms. In this study, we developed a deep learning model using real-world data to assist a diagnosis and determine the stage of the disease using retinal photographs. METHODS: This retrospective observational study conducted from August 2006 to March 2022 included 498 retinal photographs from 78 patients with MMD and 3835 photographs from 1649 healthy participants. Photographs were preprocessed, and an ResNeXt50 model was developed. Model performance was measured using receiver operating curves and their area under the receiver operating characteristic curve, accuracy, sensitivity, and F1-score. Heatmaps and progressive erasing plus progressive restoration were performed to validate the faithfulness. RESULTS: Overall, 322 retinal photographs from 67 patients with MMD and 3752 retinal photographs from 1616 healthy participants were used to develop a screening and stage prediction model for MMD. The average age of the patients with MMD was 44.1 years, and the average follow-up time was 115 months. Stage 3 photographs were the most prevalent, followed by stages 4, 5, 2, 1, and 6 and healthy. The MMD screening model had an average area under the receiver operating characteristic curve of 94.6%, with 89.8% sensitivity and 90.4% specificity at the best cutoff point. MMD stage prediction models had an area under the receiver operating characteristic curve of 78% or higher, with stage 3 performing the best at 93.6%. Heatmap identified the vascular region of the fundus as important for prediction, and progressive erasing plus progressive restoration result shows an area under the receiver operating characteristic curve of 70% only with 50% of the important regions. CONCLUSIONS: This study demonstrated that retinal photographs could be used as potential biomarkers for screening and staging of MMD and the disease stage could be classified by a deep learning algorithm.

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Peripapillary retinal nerve fiber layer thickness in patients with unilateral retinal vein occlusion

Cited by 6 publications

References 33 publications

Retinal vein occlusions associated or complicated with glaucoma. Aspects of prediction and paths of progression

Retinal vein occlusions associated or complicated with glaucoma. Aspects of prediction and paths of progression

Inner Retinal Changes in Acute Experimental BRVO Treated With Bevacizumab or Triamcinolone Acetonide

Screening of Moyamoya Disease From Retinal Photographs: Development and Validation of Deep Learning Algorithms

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