Peripapillary Retinal Nerve Fiber Layer Changes in Asymptomatic Essential Thrombocythemia Patients

Ayıntap, Emre; Çetin, Güven; Sadigov, Fariz; Artunay, Özgür; Akkan, Julide Canan Umurhan; Koytak, İbrahim Arif; Tuncer, Kemal

doi:10.3109/02713683.2014.906624

Cited by 3 publications

(2 citation statements)

References 18 publications

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“…Ayintap et al investigated peripapillary retinal nerve fibre layer thickness (RNFL) in 30 ET patients and compared the thickness with age, sex, race and refractive error-matched controls. ET patient had an average RNFL, which was 8.44% thinner compared to the controls, but the difference was not statistically significant (P = 0.226) [52].…”

Section: Retina and Choroidmentioning

confidence: 72%

Ocular Manifestations in Patients with Philadelphia-Negative Myeloproliferative Neoplasms

Liisborg

Hasselbalch

Sørensen

2020

Cancers

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The major complications of Philadelphia-negative (Ph-Negative) myeloproliferative neoplasms (MPNs) are thrombosis, haemorrhage and leukemic transformation. As systemic and haematological diseases, MPNs have the potential to affect many tissues and organs. Some complications lead to the diagnosis of MPNs, but other signs and symptoms are often misdiagnosed or neglected as a sign of MPN disease. Therefore, we reviewed the current literature to investigate and delineate the clinical manifestations seen in the eyes of Ph-negative MPN patients. We found that ocular manifestations are common among patients with MPNs. The most frequently described manifestations are due to the consequences of haematological abnormalities causing microvascular disturbances and hyperviscosity. More serious and vision-threatening complications as thrombotic events in the eyes have been repeatedly reported as well. These ocular symptoms may precede more serious extraocular complications. Accordingly, combined ophthalmological and haematological management have the potential to discover these diseases earlier and prevent morbidity and mortality in these patients. Furthermore, routine ophthalmological screening of all newly diagnosed MPN patients may be a preventive approach for early diagnosis and timely treatment of the ocular manifestations.

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Section: Retina and Choroidmentioning

confidence: 72%

Ocular Manifestations in Patients with Philadelphia-Negative Myeloproliferative Neoplasms

Liisborg

Hasselbalch

Sørensen

2020

Cancers

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“…Both ET and SCR have been shown to lead to peripapillary retinal nerve fiber layer thinning secondary to ischemia in patients even without pre-existing glaucoma. 9 , 10 A recent article exploring retinal microvascular abnormalities in patients with sickle cell disease (using OCT [optical coherence tomography] angiography) discovered that sickled blood cells within retinal capillaries created intermittent vascular stasis and subsequent thrombus formation. 11 This thrombus formation may lead to impaired capillary perfusion and retinal ischemia.…”

Section: Discussionmentioning

confidence: 99%

Retinal neovascularization in the setting of CALR-mutation positive essential thrombocythemia

Heydinger,

Abdulaal,

Wang

2023

SAGE Open Medical Case Reports

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Patients with Calreticulin ( CALR) mutation positive essential thrombocythemia are often thought of as having a “low-risk” of thrombotic complications. This report examines a case of a patient with CALR-mutation positive essential thrombocythemia presenting with peripheral retinal ischemia and subsequent retinal neovascularization. This patient had a 2-year documented history of CALR-mutation positive essential thrombocythemia with a maximum platelet count of over 800,000 cells/µL. Fluorescein angiogram showed significant leakage in the areas of the vascular lesions with peripheral vascular nonperfusion consistent with neovascularization. The patient was treated with photocoagulation to the areas of avascular retina. At 6-month follow-up, some regression of neovascularization was noted with no signs of progression in the retinopathy. Furthermore, essential thrombocythemia patients can present with neovascularization secondary to retinal ischemia due to microvascular thrombotic events. Identification of these changes is important for guiding medical and procedural interventions in order to preserve vision.

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Evaluation of trace elements in essential thrombocytosis and reactive thrombocytosis

Tekin

Karış

Alkan

et al. 2022

Journal of Trace Elements in Medicine and Biology

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Peripapillary Retinal Nerve Fiber Layer Changes in Asymptomatic Essential Thrombocythemia Patients

Abstract: Asymptomatic ET patients may have peripapillary RNFL thinning as a result of their systemic illness. This study is the first to demonstrate peripapillary RFNL changes in asymptomatic ET patients.

Cited by 3 publications

References 18 publications

Ocular Manifestations in Patients with Philadelphia-Negative Myeloproliferative Neoplasms

Ocular Manifestations in Patients with Philadelphia-Negative Myeloproliferative Neoplasms

Retinal neovascularization in the setting of CALR-mutation positive essential thrombocythemia

Evaluation of trace elements in essential thrombocytosis and reactive thrombocytosis

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