Peripapillary Vessel Density Reversal after Trabeculectomy in Glaucoma

In, Jung Hee; Lee, So Yeon; Cho, Seok Ho; Hong, Young Jae

doi:10.1155/2018/8909714

Cited by 30 publications

(52 citation statements)

References 33 publications

(31 reference statements)

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“…Generalizability may be limited due to the small sample size, predominantly Caucasian population, and exclusion of eyes with high myopia, tilted discs, or previous glaucoma surgeries, which may affect OCTA measurements. 64 Retinal microvasculature can be negatively affected by aging, 65 yet we observed decreased ONH and peripapillary vessel density in patients with POAG, who were younger than controls. Although we tried to address the age difference during recruiting, we ultimately adjusted for age in multivariable analyses.…”

Section: Discussionmentioning

confidence: 64%

Paired Optic Nerve Microvasculature and Nailfold Capillary Measurements in Primary Open-Angle Glaucoma

Shoji

Cousins

Saini

et al. 2021

Trans. Vis. Sci. Tech.

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Purpose To assess microvascular beds in the optic nerve head (ONH), peripapillary tissue, and the nailfold in patients with primary open-angle glaucoma (POAG) versus controls. Methods Patients with POAG (n = 22) and controls (n = 12) underwent swept-source optical coherence tomography angiography of ophthalmic microvasculature and nailfold video capillaroscopy of the hand. The main outcomes were vessel density (VD) and blood flow of the ONH, the peripapillary and the nailfold microvasculatures. Results Patients with POAG were younger than controls (63.5 ± 9.4 vs. 69.9 ± 6.5 years, P = 0.03). Deep ONH VD and blood flow were lower in patients with POAG than controls (39.1% ± 3.5% vs. 43.8% ± 5.7%; 37.8% ± 5.3% vs. 46.0% ± 7.8%, respectively, P < 0.02 for both); similar results were observed with peripapillary VD (37.9 ± 2.6%, 43.4 ± 7.6%, respectively, P = 0.03). Nailfold capillary density and blood flow were lower in patients with POAG than controls (8.8 ± 1.0 vs. 9.8 ± 0.9 capillaries/mm; 19.9 ± 9.4 vs. 33.7 ± 9.8 pL/s, respectively; P < 0.009 for both). After adjusting for age and gender, deep ONH VD and blood flow, peripapillary VD, and nailfold capillary blood flow were lower in POAG than controls (β = −0.04, −0.07, −0.05, −13.19, respectively, P ≤ 0.046 for all). Among all participants, there were positive correlations between deep ONH and nailfold capillary blood flow (Pearson's correlation coefficient r = 0.42, P = 0.02), peripapillary and nailfold capillary density (r = 0.43, P = 0.03), and peripapillary and nailfold capillary blood flow ( r = 0.49, P = 0.01). Conclusions Patients with POAG demonstrated morphologic and hemodynamic alterations in both ophthalmic and nailfold microvascular beds compared to controls. Translational Relevance The concomitant abnormalities in nailfold capillaries and relevant ocular vascular beds in POAG suggest that the microvasculature may be a target for POAG treatment.

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Section: Discussionmentioning

confidence: 64%

Paired Optic Nerve Microvasculature and Nailfold Capillary Measurements in Primary Open-Angle Glaucoma

Shoji

Cousins

Saini

et al. 2021

Trans. Vis. Sci. Tech.

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“…From an initial selection of 4516 studies, ten 14,21,[28][29][30][31][32][33][34][35] were included in the systematic review (Figure 1). A Kappa agreement of 0.81 was obtained for the eligibility of the full-texts (good agreement).…”

Section: Study Selectionmentioning

confidence: 99%

“…The included studies had follow-up periods between 3 months 30,31,35 and 2.6 years. 21 There was a wide variation in the reported VD values, in the slab/retinal depth assessed, in the selection criteria, and the OCTA devices used.…”

Section: Figurementioning

confidence: 99%

OCT-angiography detects longitudinal microvascular changes in glaucoma: a systematic review

Miguel¹,

Silva

Breda

et al. 2021

Br J Ophthalmol

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Background/aimsOptical coherence tomography angiography (OCTA) allows the study of vessel density (VD). We intended to perform a systematic review of studies focusing on longitudinal changes in peripapillary and macular VD measurements in glaucoma.MethodsA search was performed across MEDLINE, Scopus, ISI Web of Science and Google Scholar, using the following query from inception until 20 September 2019: ((“optical coherence tomography angiography”[tiab]) OR (optical coherence tomography angiography[MeSH]) OR (“OCTA”[tiab]) OR (“OCT-A”[tiab]) OR (“angio-OCT”[tiab]) OR (“OCT- angiography”[tiab]) OR (“OCT-angio”[tiab]) OR (“OCT-angiographie”[tiab])) AND (glaucom*[tiab] OR glaucoma[MeSH]). Prospective studies that quantitatively assessed the longitudinal changes in VD in glaucoma with at least 3 months of follow-up were included.ResultsTen out of 4516 studies were included. The rate of VD change in glaucoma varied from 0.036/year to 1.08/year and 1.3% to 3.2% per year, with significantly different rates between glaucoma and healthy controls. Five studies assessed VD change after glaucoma surgery, obtaining variable results, ranging from a temporary VD decrease to increase after 3 months. Meta-analysis was not possible due to a wide variation in methods, measurements and region of VD.ConclusionOCTA is a non-invasive technology, which shows promise in glaucoma. Measures should be taken to increase the quality and standardise the methodology of VD measures in OCTA longitudinal studies, for future meta-analyses.

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“…Our study aimed to investigate the potential effect of Tafluprost on flow density in POAG patients using OCT-A examination of both the optic nerve head and the macular region in a cross-sectional approach. Hee In et al demonstrated that lowering the IOP could lead to an increased flow density correlated to the IOP reduction [43]. Therefore, an interventional approach to evaluate the effect of Tafluprost on flow density could be confounded by its IOP-lowering properties.…”

Section: Discussionmentioning

confidence: 99%

OCT angiography analysis of retinal vessel density in primary open-angle glaucoma with and without Tafluprost therapy

et al. 2020

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Background Primary open-angle glaucoma (POAG) is a progressive neurodegenerative disease which leads to irreversible blindness. An elevated intraocular pressure (IOP) is considered to be the main risk factor for the disease progression. It is known that retinal blood flow is altered in POAG eyes. Tafluprost, a prostaglandin analogue which lowers the IOP, has shown to also improve the retinal blood flow in animals. Methods The current study therefore evaluated the retinal vessel density in the peripapillary and macular region of POAG patients with normal IOP treated with topical Tafluprost (n = 20) compared to surgically treated patients with normal IOP (n = 22) using optical coherence tomography angiography (OCT-A). The retinal flow density was obtained after binarisation and evaluated in five sectors. Results There was a significantly higher peripapillary flow density in all sectors in Tafluprost treated eyes when compared to post-surgery eyes. The flow density in the inferior sector of the superficial plexus in the macular region was also significantly higher in the Tafluprost group. Conclusions: These results indicate that Tafluprost not only lowers IOP, but may also enhance retinal blood flow in POAG patients with a normal IOP.

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Peripapillary Vessel Density Reversal after Trabeculectomy in Glaucoma

Cited by 30 publications

References 33 publications

Paired Optic Nerve Microvasculature and Nailfold Capillary Measurements in Primary Open-Angle Glaucoma

Paired Optic Nerve Microvasculature and Nailfold Capillary Measurements in Primary Open-Angle Glaucoma

OCT-angiography detects longitudinal microvascular changes in glaucoma: a systematic review

OCT angiography analysis of retinal vessel density in primary open-angle glaucoma with and without Tafluprost therapy

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