Peripartum cardiomyopathy is associated with increased uric acid concentrations: A population based study

Sagy, Iftach; Salman, Amjad Abu; Kezerle, Louise; Erez, Offer; Yoel, Idan; Barski, Leonid

doi:10.1016/j.hrtlng.2017.06.004

Cited by 5 publications

(3 citation statements)

References 38 publications

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“…Similar to previous studies, 5,8,42,43 findings from this study suggest that infants born to mothers with PPCM have an increased risk for adverse birth outcomes, including prematurity and low birthweight (< 2,500 grams) compared with those born to mothers in the control cohort (Table 4). These adverse outcomes are important to note, as premature birth and low birth weight are both associated with increased infant mortality and a variety of developmental and medical issues for the child.…”

Section: Discussionsupporting

confidence: 89%

A Case-Control Study of Peripartum Cardiomyopathy Using the Rochester Epidemiology Project

Douglass

Cooper

Morales-Lara

et al. 2021

Journal of Cardiac Failure

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Section: Discussionsupporting

confidence: 89%

A Case-Control Study of Peripartum Cardiomyopathy Using the Rochester Epidemiology Project

Douglass

Cooper

Morales-Lara

et al. 2021

Journal of Cardiac Failure

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“…28) In Europe, an inter-ISOGAI, ET AL national registry of PPCM was initiated by the Heart Failure Association of the European Society of Cardiology Study Group in 2012, 29,30) but only studies in Denmark and Sweden have reported the incidence of PPCM. 31,32) Fewer studies have been conducted in Central America, 33,34) the Middle East, 35) Africa, [36][37][38][39] and to our knowledge, there are no English reports on the incidence of PPCM in South America. Most studies were performed in the 1990s to 2000s, with fewer reports after 2010.…”

Section: Worldwide Incidence Of Ppcmmentioning

confidence: 99%

Worldwide Incidence of Peripartum Cardiomyopathy and Overall Maternal Mortality

Isogai

Kamiya

2019

Int. Heart J.

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Peripartum cardiomyopathy (PPCM) is a specific cardiomyopathy in which heart failure develops due to reduced myocardial contraction during pregnancy or in the postpartum period in women without a previous history of heart disease. The epidemiology of PPCM has been reported in various countries and areas, and the incidence of PPCM differed among these reports. The incidence was highest (1 in 102 deliveries) in Nigeria and lowest (1 in 15,533 births) in Japan. The incidence was higher in African-Americans than in other races in several reports from the United States, and was also high in African countries and Haiti, indicating that the risk for PPCM is highest in the black race. However, the study design and definition of PPCM differ among studies, and these differences may influence the incidence. Moreover, the incidence of PPCM and the maternal mortality rate were well correlated. Since maternal mortality reflects the level of perinatal health care and hygiene, this finding suggests that the extent of perinatal care is partly related to the incidence of PPCM, which reflects heart failure and cardiomyopathy of unknown cause in women.

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“…Odds Ratio 95% confidence interval B1R and M2R 98 18.786 1.926 -183.262 antimyocardial IgG 99 2.68 1.19 -4.85 NT-proBNP 100 1.92 1.12 -4.15 CRP 99, 100 1.86 1.08-4.02 Uric acid 101 1.3 As PPCM and dilated cardiomyopathy (DCM) have similar clinical characteristics, and it may be that PPCM is part of the spectrum of DCM. Some patients diagnosed with PPCM may have had a previously unrecognised dilated cardiomyopathy, although in the few documented cases where echocardiography was incidentally available prior to clinical diagnosis of PPCM, ejection fraction was normal 103 .…”

Section: Biomarkermentioning

confidence: 99%

Pathophysiology and risk factors of peripartum cardiomyopathy

et al. 2022

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Peripartum cardiomyopathy (PPCM) is a potentially fatal form of idiopathic heart failure with varying incidences among countries and races. The cause of PPCM is uncertain but it may result from a combination of environmental and genetic factors, as well as pregnancy associated conditions such as pre-eclampsia. Animal studies suggested that impaired vascular and metabolic function may be central to the development of PPCM. Clarifying the pathogenic mechanisms is necessary to establish new therapies to improve the outcomes of patients with PPCM. Pregnancy hormones tightly coordinate a plethora of maternal adaptive responses, including haemodynamic, vascular, structural, and metabolic changes of the cardiovascular system. While pregnancy is considered to be a cardiovascular challenge, hormonal effects uniquely drive systemic insulin resistance and mostly fatty acid-dependent cardiac metabolism. In PPCM, the peripartum period is associated with profound and rapid hormonal changes that result in a brief period of disrupted cardiovascular (metabolic) homeostasis prone to secondary perturbations. This review summarizes and reflects on recent literature on the potential pathophysiological mechanisms and risk factors for PPCM with a focus on the maternal cardiovascular changes associated with pregnancy. We provide an updated framework to improve understanding of PPCM pathogenesis, which may lead to a better disease definition.

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Peripartum cardiomyopathy is associated with increased uric acid concentrations: A population based study

Cited by 5 publications

References 38 publications

A Case-Control Study of Peripartum Cardiomyopathy Using the Rochester Epidemiology Project

A Case-Control Study of Peripartum Cardiomyopathy Using the Rochester Epidemiology Project

Worldwide Incidence of Peripartum Cardiomyopathy and Overall Maternal Mortality

Pathophysiology and risk factors of peripartum cardiomyopathy

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