Peripersonal and extrapersonal visuospatial neglect in different frames of reference: A brain lesion-symptom mapping study

Brink, Antonia F. Ten; Biesbroek, J. Matthijs; Oort, Quirien; Visser‐Meily, Johanna M. A.; Nijboer, Tanja C.W.

doi:10.1016/j.bbr.2018.06.010

Cited by 33 publications

(17 citation statements)

References 67 publications

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“…Alternatively, it is possible that the association between the intercalcarine cortex and egocentric neglect is indicative of a general association between PCA strokes and egocentric neglect. There is a degree of debate surrounding whether patients with visual field deficits or exclusively occipital lesions should be included in lesion mapping analyses aiming to identify the correlates of neglect ( Ten Brink et al, 2019 ). However, this study aims to accurately represent the anatomical heterogeneity present within the stroke population and excluding these patients would remove a key, underrepresented patient group from this analysis ( Bird, 2006 ; Mort et al, 2003 ).…”

Section: Discussionmentioning

confidence: 99%

Right and left neglect are not anatomically homologous: A voxel-lesion symptom mapping study

2021

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: Discussionmentioning

confidence: 99%

Right and left neglect are not anatomically homologous: A voxel-lesion symptom mapping study

2021

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“…Patients can selectively exhibit neglect within peri-personal (near space) and extra-personal space. [20][21][22][23] Patients have also been found to exhibit spatial attentional biases in additional sensory modalities including auditory neglect [24][25][26] and motor neglect. [27][28][29] However, standardised neuropsychological tests which can reliably detect and differentiate between these additional neglect subtypes are not commonly employed in clinical environments.…”

Section: Introductionmentioning

confidence: 99%

Recovery of Visuospatial Neglect Subtypes and Relationship to Functional Outcome Six Months After Stroke

Moore

Vancleef

Riddoch

et al. 2021

Neurorehabil Neural Repair

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Background/Objective. This study aims to investigate how complex visuospatial neglect behavioural phenotypes predict long-term outcomes, both in terms of neglect recovery and broader functional outcomes after 6 months post-stroke. Methods. This study presents a secondary cohort study of acute and 6-month follow-up data from 400 stroke survivors who completed the Oxford Cognitive Screen’s Cancellation Task. At follow-up, patients also completed the Stroke Impact Scale questionnaire. These data were analysed to identify whether any specific combination of neglect symptoms is more likely to result in long-lasting neglect or higher levels of functional impairment, therefore warranting more targeted rehabilitation. Results. Overall, 98/142 (69%) neglect cases recovered by follow-up, and there was no significant difference in the persistence of egocentric/allocentric (X2 [1] = .66 and P = .418) or left/right neglect (X2 [2] = .781 and P = .677). Egocentric neglect was found to follow a proportional recovery pattern with all patients demonstrating a similar level of improvement over time. Conversely, allocentric neglect followed a non-proportional recovery pattern with chronic neglect patients exhibiting a slower rate of improvement than those who recovered. A multiple regression analysis revealed that the initial severity of acute allocentric, but not egocentric, neglect impairment acted as a significant predictor of poor long-term functional outcomes (F [9,300] = 4.742, P < .001 and adjusted R2 = .098). Conclusions. Our findings call for systematic neuropsychological assessment of both egocentric and allocentric neglect following stroke, as the occurrence and severity of these conditions may help predict recovery outcomes over and above stroke severity alone.

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“…There are additional, independent subtypes of neglect which were not included in this investigation. Neglect can selectively impact additional spatial coordinates (e.g., peri-personal/extra-personal neglect [Butler et al, 2009;Ten Brink et al, 2019]) or sensory modalities (e.g., auditory neglect [Bellmann et al, 2001]). It is plausible that each of these additional neglect subtypes may be associated with distinct patterns of functional impairment.…”

Section: Limitationsmentioning

confidence: 99%

Aligning formal and functional assessments of Visuospatial Neglect: A mixed-methods study

Moore

Driscoll

Colwell

et al. 2021

Neuropsychological Rehabilitation

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The occurrence of visuospatial neglect acts as a key predictor of recovery outcome following stroke. However, the specific behavioural profiles associated with various neglect subtypes are not well understood. This study aims to identify realworld functional impairments associated with neglect, to determine whether functional impairment profiles differ across patients with egocentric and allocentric neglect, and to investigate how neglect severity predicts functional impairments.Notes from 290 stroke patients' occupational therapy functional assessments were qualitatively and quantitatively analysed in the context of neglect type and severity as reported by the OCS Cancellation Task. Overall, neglect patients had more references to having difficulty initiating tasks, finding items, exhibiting spatial inattention, and having difficulty using both arms than patients without neglect. The proportion of theme references did not differ significantly across patients with egocentric and allocentric neglect. The quantitative severity of egocentric neglect was acted as a significant predictor of reference occurrence over and above stroke severity within difficulty finding items, spatial inattention, body inattention, and upper limb use.This study expands on previous findings by identifying real-world functional impairments differentiating patients with and without neglect. This data provides novel insight into the impact of neglect on functional abilities.

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Peripersonal and extrapersonal visuospatial neglect in different frames of reference: A brain lesion-symptom mapping study

Cited by 33 publications

References 67 publications

Right and left neglect are not anatomically homologous: A voxel-lesion symptom mapping study

Right and left neglect are not anatomically homologous: A voxel-lesion symptom mapping study

Recovery of Visuospatial Neglect Subtypes and Relationship to Functional Outcome Six Months After Stroke

Aligning formal and functional assessments of Visuospatial Neglect: A mixed-methods study

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