Peripheral Acanthomatous Ameloblasoma in a Rabbit with Review of Previous Submissions of the Armed Forces Institute of Pathology Wednesday Slide Conference

Madarame, Hiroo; Enaga, S.

doi:10.1292/jvms.71.987

Cited by 7 publications

(6 citation statements)

References 9 publications

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“…2001, Brower et al . 2006, Madarame & Enaga 2009) and applicable clinical and pathological data are limited. This retrospective study aims to classify the oral tumours identified in 18 rabbits and to describe their clinical features as compared to similar masses in dogs and cats.…”

Section: Introductionmentioning

confidence: 99%

Spontaneous oral tumours in 18 rabbits (2005–2015)

Miwa

Nakata

Takimoto

et al. 2019

J of Small Animal Practice

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This retrospective study of a series of 18 cases aimed to describe the clinical and pathological findings of oral tumours in rabbits, as there have been few reports detailing spontaneous oral tumours in this species. A total of 13 different tumour types were diagnosed: squamous cell carcinoma (three), ameloblastoma (two), fibrosarcoma (two), osteosarcoma (two), cementoma (one), complex odontoma (one), giant cell epulis (one), sarcoma (one), chondrosarcoma (one), trichoepithelioma (one), papilloma (one), malignant melanoma (one) and basal cell carcinoma (one). Odontogenic tumours were relatively common in this study as compared to the oral tumours typically identified in dogs and cats. The most common clinical sign in this study was feeding abnormalities. Surgical excision and radiation therapy were found to be effective in rabbits.

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Section: Introductionmentioning

confidence: 99%

Spontaneous oral tumours in 18 rabbits (2005–2015)

Miwa

Nakata

Takimoto

et al. 2019

J of Small Animal Practice

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“…2,8–10 Ameloblastomas are more commonly reported in humans, dogs, and horses; however, they have also been infrequently reported in cattle, sheep, rodents, rabbits, buffalo, camelids, nonhuman primates, fish, snakes, and cats. 1,3,6–8,11–21…”

Section: Introductionmentioning

confidence: 99%

Maxillary Ameloblastoma in an Asiatic Black Bear (Ursus thibetanus)

McCleery¹,

Thurber

Lux

et al. 2023

J Vet Dent

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An approximately 30-year-old intact female Asiatic black bear ( Ursus thibetanus) was presented for annual examination and a history of ptyalism. A large 9.5 cm × 5 cm × 5 cm, firm, round mass was identified attached to the hard palate on physical examination. A computed tomography scan was performed, and the heterogeneous, mineral-attenuating mass was seen arising from the right aspect of the palatine bone and extending rostrally to the level of the last maxillary molars, caudally into the oropharynx, and dorsally into the nasal choana. Surgical debulking was performed to remove the portion of the mass within the oral cavity. Histopathologic analysis was consistent with a keratinizing ameloblastoma. Nine months postoperatively, the patient was asymptomatic for the tumor. The patient was euthanized 23-months postoperatively, and severe diffuse pustular dermatitis, growth of the ameloblastoma on the hard palate, and various degenerative and aging changes were noted on necropsy at that time. This is the first report of an ameloblastoma in a member of the Ursidae family.

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“…11 From the few cases described in the peer-reviewed literature, leporine odontogenic tumors tend to occur in adult animals and have a predisposition for the maxilla. Odontogenic neoplasms that have been described arising from the mandible or gingival mucosa of rabbits include ameloblastoma, 2,10,11,16 complex odontoma, 11 and ameloblastic fibroma. 17 Ameloblastomas arising ectopically from the cheek tissue of 2 rabbits have also been described in the peer-reviewed literature.…”

mentioning

confidence: 99%

“…17 Ameloblastomas arising ectopically from the cheek tissue of 2 rabbits have also been described in the peer-reviewed literature. 10 In human patients, approximately 80% of ameloblastomas are found in the mandible, followed by the maxilla; ameloblastomas arising from the sinonasal tract are rare. 5 Different investigators have come to markedly different conclusions regarding the prevalence of oral odontogenic tumors in rabbits.…”

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confidence: 99%

Odontogenic-like neoplasms of the rabbit cheek: pathological features and comparison to cutaneous trichoblastoma and jaw-associated ameloblastoma

Murphy

Swan²,

Affolter

et al. 2023

Vet Pathol

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Odontogenic neoplasms demonstrate unique histopathological features and are thought to arise from the germinal tissues of the developing tooth germ, effectively restricting their anatomic origin to the tooth-bearing regions of the jaw and directly associated soft tissues of the oral cavity. Ectopic odontogenic-like neoplasms located in the skin of cats, rabbits, and human beings challenge these assumptions. Here we describe the clinical, pathological, and immunohistochemical features of 6 spontaneously occurring odontogenic-like neoplasms arising in the cutaneous tissue of the cheek in client-owned pet rabbits, including ameloblastoma-like (n = 3), ameloblastic fibroma-like (n = 2), and ameloblastic carcinoma-like neoplasms (n = 1). Microscopically, all the cheek tumors featured neoplastic epithelium exhibiting odontogenic architectural structures (plexiform ribbons, anastomosing trabeculae, follicles, cysts, and irregular structures with rounded botryoid protuberances) and 1 or more cardinal odontogenic epithelial features (basal palisading, antibasilar nuclei, and central stellate reticulum–like cells). The pancytokeratin, cytokeratin 5/6, cytokeratin 14, and vimentin immunohistochemical patterns of these odontogenic-like lesions were most similar to those of jaw-associated ameloblastoma and differed from those of cutaneous trichoblastoma. All neoplasms were narrowly excised, and for lesions with clinical follow-up information, none had evidence of recurrence 1–7 months after surgical removal. Although evidence suggests that these odontogenic-like tumors of the rabbit cheek may be derived from ectopic rests of transformed tooth germ, the histogenesis of these lesions remains unresolved.

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Peripheral Acanthomatous Ameloblasoma in a Rabbit with Review of Previous Submissions of the Armed Forces Institute of Pathology Wednesday Slide Conference

Cited by 7 publications

References 9 publications

Spontaneous oral tumours in 18 rabbits (2005–2015)

Spontaneous oral tumours in 18 rabbits (2005–2015)

Maxillary Ameloblastoma in an Asiatic Black Bear (Ursus thibetanus)

Odontogenic-like neoplasms of the rabbit cheek: pathological features and comparison to cutaneous trichoblastoma and jaw-associated ameloblastoma

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