Peripheral and Autonomic Neuropathy Status of Young Patients With Type 1 Diabetes Mellitus at the Time of Transition From Pediatric Care to Adult-Oriented Diabetes Care

Vágvölgyi, Anna; Maróti, Ágnes; Szűcs, Mónika; Póczik, Csongor; Urbán-Pap, Dóra; Baczkó, István; Nemes, Attila; Csajbók, Éva; Sepp, Krisztian; Kempler, Péter; Orosz, Andrea; Várkonyi, Tamás; Lengyel, Csaba

doi:10.3389/fendo.2021.719953

Cited by 2 publications

(3 citation statements)

References 85 publications

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“…The Neuropad, an adhesive pad that contains blue salt anhydrous cobalt II chloride, is a tool that allows the evaluation of sweat dysfunction of small fibers. As mentioned above, small fibers represent 70% of the innervation; thus, describing their impairment is important to diagnose DPN early [ 98 , 99 ]. C fibers are responsible for thermal transmission, pain, and the autonomous function of sweating.…”

Section: Diagnosismentioning

confidence: 99%

Peripheral Neuropathy in Diabetes Mellitus: Pathogenetic Mechanisms and Diagnostic Options

Galiero

Caturano

Vetrano

et al. 2023

IJMS

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Diabetic neuropathy (DN) is one of the main microvascular complications of both type 1 and type 2 diabetes mellitus. Sometimes, this could already be present at the time of diagnosis for type 2 diabetes mellitus (T2DM), while it appears in subjects with type 1 diabetes mellitus (T1DM) almost 10 years after the onset of the disease. The impairment can involve both somatic fibers of the peripheral nervous system, with sensory-motor manifestations, as well as the autonomic system, with neurovegetative multiorgan manifestations through an impairment of sympathetic/parasympathetic conduction. It seems that, both indirectly and directly, the hyperglycemic state and oxygen delivery reduction through the vasa nervorum can determine inflammatory damage, which in turn is responsible for the alteration of the activity of the nerves. The symptoms and signs are therefore various, although symmetrical painful somatic neuropathy at the level of the lower limbs seems the most frequent manifestation. The pathophysiological aspects underlying the onset and progression of DN are not entirely clear. The purpose of this review is to shed light on the most recent discoveries in the pathophysiological and diagnostic fields concerning this complex and frequent complication of diabetes mellitus.

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Section: Diagnosismentioning

confidence: 99%

Peripheral Neuropathy in Diabetes Mellitus: Pathogenetic Mechanisms and Diagnostic Options

Galiero

Caturano

Vetrano

et al. 2023

IJMS

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“…The sum of the scores gave the total ANS (range 0–10). A score was considered to be normal if 0–1, borderline if 2–3 and abnormal if >3 5,15,16 …”

Section: Methodsmentioning

confidence: 99%

“…Autonomic function was assessed by means of 5 Ewing's SCRTs. 5,15,16 For predominantly characterizing parasympathetic function:…”

Section: Autonomic Functionmentioning

confidence: 99%

Correlations between vegetative autonomic function and specific left atrial functions in healthy adults: Insights from the three‐dimensional speckle‐tracking echocardiographic MAGYAR‐Healthy Study

Nemes,

Kormányos,

Orosz

et al. 2023

J of Clinical Ultrasound

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IntroductionThe functioning of the left atrium (LA) is partly controlled by the neural system. It was purposed to evaluate correlations between the result of Ewing's 5 standard cardiovascular reflex tests (SCRTs) characterizing autonomic function and LA volumetric and functional features as assessed by three‐dimensional speckle‐tracking echocardiography (3DSTE) in healthy individuals.Materials and MethodsThe current study comprised 18 healthy volunteers being in sinus rhythm (mean age: 35 ± 12 years, 10 men). Measurement of blood pressure, ECG, 5 SCRTs, two‐dimensional Doppler echocardiography and 3DSTE were performed. These parameters were in normal ranges in all cases.ResultsFrom LA volumetric parameters, only systolic total atrial emptying fraction (r = 0.559, p = 0.037) and early diastolic passive atrial emptying fraction (r = 0.539, p = 0.047) correlated with systolic blood pressure response to standing representing sympathetic autonomic function. From LA strains, peak mean segmental LA radial strain (RS) (r = −0.532, p = 0.050), global and mean segmental LA circumferential strain (CS) (r = 0.662, p = 0.010 and r = 0.635, p = 0.015, respectively) representing systolic LA function correlated with Valsalva ratio representing parasympathetic autonomic function. Global LA‐RS (r = −0.713, p = 0.040) and LA‐CS (r = 0.657, p = 0.011) and mean segmental LA‐CS (r = 0.723, p = 0.003) at atrial contraction representing end‐diastolic atrial contraction showed correlations with Valsalva ratio, as well. Peak global and mean segmental LA‐CS (r = 0.532, p = 0.050 and r = 0.530, p = 0.050) and the same strains at atrial contraction (r = 0.704, p = 0.005 and r = 0.690, p = 0.006) representing systolic function and end‐diastolic atrial contraction correlated with systolic blood pressure response to standing representing both parasympathetic and sympathetic autonomic functions.ConclusionsSignificant correlations between features of vegetative autonomic function represented by Ewing's 5 SCRTs and specific LA functions represented by 3DSTE‐derived LA volume‐based functional properties and strains could be demonstrated in healthy adults.

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Peripheral and Autonomic Neuropathy Status of Young Patients With Type 1 Diabetes Mellitus at the Time of Transition From Pediatric Care to Adult-Oriented Diabetes Care

Cited by 2 publications

References 85 publications

Peripheral Neuropathy in Diabetes Mellitus: Pathogenetic Mechanisms and Diagnostic Options

Peripheral Neuropathy in Diabetes Mellitus: Pathogenetic Mechanisms and Diagnostic Options

Correlations between vegetative autonomic function and specific left atrial functions in healthy adults: Insights from the three‐dimensional speckle‐tracking echocardiographic MAGYAR‐Healthy Study

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