‘Peripheral’ and ‘central’ type benzodiazepine receptors in Maudsley rats

Tamborska, E; Insel, Thomas R.; Marangos, Paul J.

doi:10.1016/0014-2999(86)90058-0

Cited by 23 publications

(7 citation statements)

References 21 publications

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“…Rats selectively bred for 'emotional reactivity' have significant differences in their adenosine receptor densities; the more emotional Maudsley Reactive strain showing significantly greater adenosine receptor binding sites per unit protein than the less emotional Maudsley Non-Reactive strain (Marangos et al 1987a). Interestingly, the same group found no differences between the strains for benzodiazepine binding sites (Tamborska et al 1986) contrary to previous findings (Robertson et al 1978).…”

Section: Anxiety Disorderscontrasting

confidence: 76%

Prospective role for adenosine and adenosinergic systems in psychiatric disorders

Durcan¹,

Morgan²

1990

Psychol. Med.

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Section: Anxiety Disorderscontrasting

confidence: 76%

Prospective role for adenosine and adenosinergic systems in psychiatric disorders

Durcan¹,

Morgan²

1990

Psychol. Med.

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“…Although these lines were developed in different rat strains and selected based on disparate behavioral phenotypes, there is considerable convergence across models such that animals exhibiting relatively higher levels of anxiety‐like behavior also show enhanced levels of depression‐like behavior in the FST and other tests (Abel, ; Abel, Altman, & Commissaris, ; Commissaris, Verbanac, Markovska, Altman, & Hill, ; Einat, Belmaker, Zangen, Overstreet, & Yadid, ; Keck et al, ; Liebsch, Montkowski, Holsboer, & Landgraf, ; Muigg et al, ; Overstreet, ; Overstreet, Pucilowski, Rezvani, & Janowsky, ; Overstreet, Rezvani, & Janowsky, ). Moreover, many of these models report similar neurobiological differences between the “anxious/depressive” and “nonanxious/non‐depressive” lines, with several studies pointing to differences in the hippocampus (Corda, Lecca, Piras, Di Chiara, & Giorgi, ; Epps et al, ; Escorihuela, Tobena, & Fernandez‐Teruel, ; Garcia‐Falgueras, Castillo‐Ruiz, Put, Tobena, & Fernandez‐Teruel, ; Kalisch et al, ; Serra et al, ; Tabb, Boss‐Williams, Weiss, & Weinshenker, ; Tamborska, Insel, & Marangos, ; Weiss et al, ; Whatley, Perrett, Zamani, & Gray, ). For instance, the HAB rats (that exhibit a behavioral profile quite similar to our bred LR rats) exhibit enhanced hippocampal activation (cfos expression) following certain stressors such as the FST (Muigg et al, ) as well as reduced survival of newborn neurons (Lucassen et al, ), reduced hippocampal serotonin 5HT1a receptor expression and increased serotonin transporter (SERT) expression (Keck et al, ) compared to the HR‐like LAB rats.…”

Section: Discussionmentioning

confidence: 94%

“…show enhanced levels of depression-like behavior in the FST and other tests (Abel, 1991;Abel, Altman, & Commissaris, 1992;Commissaris, Verbanac, Markovska, Altman, & Hill, 1996;Einat, Belmaker, Zangen, Overstreet, & Yadid, 2002;Keck et al, 2003;Liebsch, Montkowski, Holsboer, & Landgraf, 1998;Muigg et al, 2007;Overstreet, 1986;Overstreet, Pucilowski, Rezvani, & Janowsky, 1995;Overstreet, Rezvani, & Janowsky, 1992). Moreover, many of these models report similar neurobiological differences between the "anxious/depressive" and "nonanxious/non-depressive" lines, with several studies pointing to differences in the hippocampus (Corda, Lecca, Piras, Di Chiara, & Giorgi, 1997;Epps et al, 2012;Escorihuela, Tobena, & Fernandez-Teruel, 1995;Garcia-Falgueras, Castillo-Ruiz, Put, Tobena, & Fernandez-Teruel, 2012;Kalisch et al, 2006;Serra et al, 2017;Tabb, Boss-Williams, Weiss, & Weinshenker, 2007;Tamborska, Insel, & Marangos, 1986;Weiss et al, 2008;Whatley, Perrett, Zamani, & Gray, 1992). For instance, the HAB rats (that exhibit a behavioral profile quite similar to our bred LR rats) exhibit enhanced hippocampal activation (cfos expression) following certain stressors such as the FST (Muigg et al, 2007) (Meaney, 2001).…”

Section: Hippocampal Changes In Other Rodent Models Of Emotional Bementioning

confidence: 97%

Rats bred for high anxiety exhibit distinct fear‐related coping behavior, hippocampal physiology, and synaptic plasticity‐related gene expression

et al. 2019

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The hippocampus is essential for learning and memory but also regulates emotional behavior. We previously identified the hippocampus as a major brain region that differs in rats bred for emotionality differences. Rats bred for low novelty response (LRs) exhibit high levels of anxiety‐ and depression‐like behavior compared to high novelty responder (HR) rats. Manipulating the hippocampus of high‐anxiety LR rats improves their behavior, although no work to date has examined possible HR/LR differences in hippocampal synaptic physiology. Thus, the current study examined hippocampal slice electrophysiology, dendritic spine density, and transcriptome profiling in HR/LR hippocampus, and compared performance on three hippocampus‐dependent tasks: The Morris water maze, contextual fear conditioning, and active avoidance. Our physiology experiments revealed increased long‐term potentiation (LTP) at CA3–CA1 synapses in HR versus LR hippocampus, and Golgi analysis found an increased number of dendritic spines in basal layer of CA1 pyramidal cells in HR versus LR rats. Transcriptome data revealed glutamate neurotransmission as the top functional pathway differing in the HR/LR hippocampus. Our behavioral experiments showed that HR/LR rats exhibit similar learning and memory capability in the Morris water maze, although the groups differed in fear‐related tasks. LR rats displayed greater freezing behavior in the fear‐conditioning task, and HR/LR rats adopted distinct behavioral strategies in the active avoidance task. In the active avoidance task, HRs avoided footshock stress by pressing a lever when presented with a warning cue; LR rats, on the other hand, waited until footshocks began before pressing the lever to stop them. Taken together, these findings concur with prior observations of HR rats generally exhibiting active stress coping behavior while LRs exhibit reactive coping. Overall, our current findings coupled with previous work suggest that HR/LR differences in stress reactivity and stress coping may derive, at least in part, from differences in the developing and adult hippocampus.

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“…The MNRA rats have also been found to be more responsive to the anticonflict effects of diazepam and pentobarbital (Commissaris, Harrington, & Altman, 1990;Commissaris et al, 1986).Whether or not these latter differences might be related to benzodiazepine receptor populations is not clear because there are conflicting data on this issue. One study (Robertson, Martin, & Candy, 1978) reported more benzodiazepine receptors in MNRA rats, but a later study reported no reliable difference between rats from the two strains (Tamborska, Insel, & Marganos, 1986). Another recent study (Drugan, Basile, Crawley, Paul, & Skolnick, 1987) found that the Maudsley strains did differ in terms of peripheral benzodiazepine sites (PBS), with concentrations of PBS being lower in the heart and kidney of the MR rats.…”

mentioning

confidence: 99%

Behavior of Maudsley reactive and nonreactive rats (Rattus norvegicus) in three consummatory contrast paradigms.

Rowan-Szal

Flaherty²

1991

Journal of Comparative Psychology

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Maudsley reactive (MR/Har) and nonreactive (MNRA/Har) rats (Rattus norvegicus) were tested in successive, simultaneous, and anticipatory contrast procedures. The MR/Har rats showed smaller successive negative contrast effects than the MNRA/Har rats when shifted from 32% to 4% sucrose, and the degree of contrast was smaller in animals of both strains than that typically obtained with unselected Sprague-Dawley derived rats. Chlordiazepoxide (4 and 8 mg/kg), which typically reduces contrast, did not influence degree of contrast in rats of either strain. Animals of both strains showed positive and negative contrast in the simultaneous contrast procedure, but degree of contrast in both cases was smaller in rats of the MR/Har strain. Animals of both strains also showed anticipatory contrast when a 0.15% saccharin solution preceded 32% sucrose in once-per-day pairings. In terms of latency to initiate licking, the MNRA/Har rats showed a contrast effect, but the MR/Har rats showed a "reinforcement" effect--shorter latency when saccharin preceded sucrose than when saccharin preceded saccharin. Open-field tests showed typical strain differences: The MNRA/Har rats ambulated more, reared more, defecated less, and showed less thigmotaxis than the MR/Har rats.

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‘Peripheral’ and ‘central’ type benzodiazepine receptors in Maudsley rats

Cited by 23 publications

References 21 publications

Prospective role for adenosine and adenosinergic systems in psychiatric disorders

Prospective role for adenosine and adenosinergic systems in psychiatric disorders

Rats bred for high anxiety exhibit distinct fear‐related coping behavior, hippocampal physiology, and synaptic plasticity‐related gene expression

Behavior of Maudsley reactive and nonreactive rats (Rattus norvegicus) in three consummatory contrast paradigms.

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