Peripheral and mesenteric serum levels of CEA and cytokeratins, staging and histopathological variables in colorectal adenocarcinoma

Ivankovics, Ivan Gregório; Fernandes, Leandro; Saad, Sarhan Sydeney; Matos, Délcio

doi:10.3748/wjg.14.6699

Cited by 8 publications

(11 citation statements)

References 19 publications

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“…CEA is the most commonly used tumour marker for CRC because its assessment method is standardised, accessible, and affordable, motivating research studies on its preoperative prognostic ability and usefulness for postoperatively monitoring recurrence following curative surgery and evaluating the chemotherapy response (12,15) . Studies examining tumour marker samples collected from the peripheral or main drainage veins of colorectal tumours have revealed that these markers' levels are higher when the samples are collected from blood vessels near the tumour, suggesting that the marker levels in the peripheral vessels do not correspond to the total amount produced (7,17,18,20) . In this study, the CEA values in the inferior mesenteric vein were significantly higher than in the peripheral venous blood when the patients were considered as a single group.…”

Section: Discussionmentioning

confidence: 99%

“…The evaluation of mesenteric and peripheral CEA levels in CRC patients has revealed a higher index at stage IV of the TNM classification, especially as the tumour extends beyond the intestinal wall (7) . Fernandes et al (5) reported a similar finding: increased CEA levels are related to occult metastases in the lymph nodes and/or liver parenchyma.…”

Section: Discussionmentioning

confidence: 99%

“…Ivankovics et al (7) analysed the differences between the peripheral and mesenteric venous blood levels and cytokeratins in 138 surgically treated CRC patients. They found that the mesenteric CEA levels were highest in the subjects with advanced tumours exhibiting macroscopic vegetative characteristics and venous invasion.…”

Section: Discussionmentioning

confidence: 99%

“…Several researchers have determined that high CEA serum levels prior to tumour resections are related to a higher recurrence index and, consequently, to the worst prognosis (7,17,18,23) . The serum CEA levels resulting from rectal tumours may vary according to the tumour's location.…”

Section: Discussionmentioning

confidence: 99%

“…Colorectal cancer (CRC) is the third most common type of neoplasia worldwide, with approximately one million new cases annually, accounting for half a million deaths (7) . Mortality rates have not decreased significantly in recent decades, despite advances in diagnosing CRC and its metastases and improved surgical techniques and postoperative care.…”

Section: Introductionmentioning

confidence: 99%

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Carcinoembryonic Antigen Levels in the Peripheral and Mesenteric Venous Blood of Patients With Rectal Carcinoma

Rezende

Palma

Toloi

et al. 2013

Arq. Gastroenterol.

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ContextThe serum carcinoembryonic antigen (CEA) is an important prognostic factor in colorectal cancer, however the rectum presents different routes of venous drainage, stating that the level of CEA in peripheral and mesenteric rectal tumors may be different, depending on the location of the tumor in the rectal segment.ObjectiveThe goal of this study was to evaluate the relationship between the peripheral and mesenteric venous levels of CEA and the association between these levels and the tumour location in the rectums of patients successfully operated on for rectal carcinoma.MethodsThirty-two patients who were surgically treated for rectal carcinoma were divided into patients with tumours located in the upper rectum (n = 11) or lower rectum (n = 21). The CEA values were assessed by electrochemiluminescence immunoassay. Serum and mesenteric CEA levels were associated with the tumour anatomopathological characteristics: location, histological type, cellular differentiation grade, depth of invasion into the rectal wall, angiolymphatic invasion, tumour, node, and metastasis staging; and the CEA index (≤1.0 or ≥1.0 ng /mL).ResultsAnalysis of the serum CEA values using clinical and anatomopathological parameters revealed no significant association with tumour location, histological type, cellular differentiation grade, depth of invasion into the intestinal wall, and tumour, node, and metastasis staging. The mesenteric CEA levels were significantly associated with the tumour location (P = 0.01). The CEA values in the mesenteric venous blood and the presence of angiolymphatic invasion (P = 0.047) were significantly different. A significant relationship was found between the CEA index value and the rectal tumour location (P = 0.0001).ConclusionsThe CEA levels were higher in the mesenteric vein in tumours located in the upper rectum and in the presence of angiolymphatic invasion. CEA drainage from lower rectum adenocarcinomas preferentially occurs through the systemic pathway.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Carcinoembryonic Antigen Levels in the Peripheral and Mesenteric Venous Blood of Patients With Rectal Carcinoma

Rezende

Palma

Toloi

et al. 2013

Arq. Gastroenterol.

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Eosinophils may serve as CEA-secreting cells for allergic bronchopulmonary aspergillosis (ABPA) patients

Yang

Gao

et al. 2021

Sci Rep

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Allergic bronchopulmonary aspergillosis (ABPA) is a condition characterized by an exaggerated response of the immune system to the fungus Aspergillus. This study aimed to assess the relationship between carcinoembryonic antigen (CEA) and eosinophils in ABPA patients. We describes a case of a 50-year-old patient who was diagnosed with ABPA presenting with high level of CEA and eosinophils. Besides,we used immunohistochemistry and immunofluorescence to identify eosinophils and CEA in sections which were obtained by Endobronchial ultrasound-guided transbronchial lung biopsy aspiration (EBUS-TBLB). The sections were then visualized using confocal microscopy. We also retrospectively analyzed a cohort of 37 ABPA patients between January 2013 and December 2019 in our hospital. We found the patient whose serum CEA levels were consistent with eosinophils during the follow-up (r = 0.929, P = 0.022). The positive expression of CEA and abnormal expression of eosinophils was higher in the ABPA tissue compared to the normal lung tissue. The co-localization was represented as pixels containing both red and green color in the image (with various shades of orange and yellow) which signified that eosinophils were immunohistochemically positive for CEA. Patients with higher levels of eosinophils had higher levels of CEA in the serum (P < 0.001). The results of Pearson correlation analysis showed that the levels of eosinophils were positively correlated with serum CEA levels (r = 0.459 and r = 0.506, P = 0.004 and P = 0.001). Serum CEA level is elevated in ABPA patients. The elevated serum CEA level was shown to be normalized after treatment. Increased CEA levels in ABPA patients may be positively correlated with eosinophil levels, and eosinophils may be served as CEA-secreting cells in patients with ABPA.

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Differential MIR-21 Expression in Plasma From Mesenteric Versus Peripheral Veins

et al. 2015

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Findings on the role of plasma miR-21 expression in colorectal cancer are contradictory. Before reaching a peripheral vein (PV), microRNAs released by the tumor are dispersed throughout the body. We hypothesized that blood drawn from the mesenteric vein (MV) near the site of the primary tumor could provide more homogeneous information than blood drawn from the PV.We have analyzed miR-21 expression in matched samples of tumor tissue, normal tissue, MV plasma, and PV plasma in 57 surgically resected patients with colon cancer and correlated our findings with clinical characteristics and disease-free survival (DFS).miR-21 expression was higher in MV than PV plasma (P = 0.014) and in tumor than in normal tissue (P < 0.001). Patients with high levels of miR-21 in MV plasma had shorter DFS (P = 0.05) than those with low levels, and those with high levels in both MV and PV plasma had shorter DFS than all other patients (P = 0.01).Our findings suggest that the primary tumor in colon cancer releases high concentrations of miR-21 in the MV but that these concentrations are later diluted in the circulatory system. MV expression of miR-21 may be a stronger prognostic marker than PV expression.

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Peripheral and mesenteric serum levels of CEA and cytokeratins, staging and histopathological variables in colorectal adenocarcinoma

Abstract: The mesenteric levels of the tumor markers CEA and cytokeratins were higher than the peripheral levels in these colorectal adenocarcinoma patients. Higher levels of these biologic tumor markers are associated with an advanced state of cancerous dissemination.

Cited by 8 publications

References 19 publications

Carcinoembryonic Antigen Levels in the Peripheral and Mesenteric Venous Blood of Patients With Rectal Carcinoma

Carcinoembryonic Antigen Levels in the Peripheral and Mesenteric Venous Blood of Patients With Rectal Carcinoma

Eosinophils may serve as CEA-secreting cells for allergic bronchopulmonary aspergillosis (ABPA) patients

Differential MIR-21 Expression in Plasma From Mesenteric Versus Peripheral Veins

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