Peripheral Arterial Disease Assessment

Kramer, Christopher M.

doi:10.1097/rmr.0b013e31815d064c

Cited by 14 publications

(9 citation statements)

References 90 publications

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“…The same difference was also noted for ADP, inorganic phosphate [66,72] and pH [72]. The ratio of PCr/ATP (p = 0.03) and Pi/ATP (p = 0.04) were marginally, but significantly elevated [71,72], this was attributed to a reduced level of ATP in patients, a finding contradicted by other groups who found no difference in the ratios at rest or during, or the muscle's post exercise pH (p = 0.07) [71].…”

Section: Phosphocreatine (Pcr)supporting

confidence: 69%

“…The median recovery time of phosphocreatine was prolonged in patients with PAD compared to health individuals [71,72]. The same difference was also noted for ADP, inorganic phosphate [66,72] and pH [72].…”

Section: Phosphocreatine (Pcr)supporting

confidence: 61%

“…Phosphocreatine is a transport molecule and reservoir of high energy phosphate bonds. Its regeneration occurs solely in the mitochondria and is dependent on the oxygen supply and cells ability to perform oxidative phosphorylation [71]. Phosphorous (31P) nuclear magnetic resonance (NMR) spectroscopy has been used to determine calf muscle metabolism in patients with intermittent claudication as the phosphorus nuclei of DNA & RNA, phospholipids and phosphoproteins are immobile and do not produce a measurable signal.…”

Section: Phosphocreatine (Pcr)mentioning

confidence: 99%

“…(31P) NMRS can occur with time series of 36 seconds each, to allow a continuous monitoring of muscle metabolism. The test re-test reliability of the PCr recovery time constant was checked (controls = 8, PAD = 3), the intra-class correlation coefficient was r = 0.95 [71].…”

Section: Phosphocreatine (Pcr)mentioning

confidence: 99%

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Review of the adaptation of skeletal muscle in intermittent claudication

Gohil¹,

Lane²,

Coughlin³

2013

WJCD

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Background: Despite awareness about the impact of intermittent claudication (IC) on mobility, balance and quality of life; the underlying pathophysiology and alterations in muscle architecture secondary to the disease are often overlooked. This review aimed to summarize the pathophysiological muscle changes present secondary to IC. Methods: The electronic databases, Medline, EMBASE, Cinahl and AMED, were searched for studies from 1967 to August 2011. Search terms included exercise, intermittent claudication and muscle. Studies about IC which were focused on muscle histology, muscle architecture, blood flow or changes with exercise were included. Results: Of 434 studies identified, 135 unique results were found. Only 78 of these were suitable from abstract review, of which 15 were unobtainable and a further nine were identified from hand-searching references. Studies in animal models demonstrated a predominance of type II muscle fibres and an improvement in animal exercise tolerance secondary to training. Exercise alone was never able to improve distances to that of healthy controls, however a lower limb fistula along with exercise did. Lower limb blood flow was demonstrated to be affected regionally, and most evident during exercise with a prolonged return to normal in patients with IC. At a cellular level, the myocytes metabolism increased in those with IC, but returned to normal post-revascularization. Conclusion: Treatment for claudicants includes either revascularization or exercise. Successful revascularization has demonstrated a return to normal muscle metabolism; the underlying physiological improvement secondary to exercise still requires clarification.

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Section: Phosphocreatine (Pcr)supporting

confidence: 69%

Section: Phosphocreatine (Pcr)supporting

confidence: 61%

Section: Phosphocreatine (Pcr)mentioning

confidence: 99%

Section: Phosphocreatine (Pcr)mentioning

confidence: 99%

See 2 more Smart Citations

Review of the adaptation of skeletal muscle in intermittent claudication

Gohil¹,

Lane²,

Coughlin³

2013

WJCD

View full text Add to dashboard Cite

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“…Although exercise-induced functional alterations in metabolism have been proposed, there is a need to integrate approaches that provide additional risk measures in PAD that can be translated into clinical practice [1]. Recently, quantitative T1/T2 mapping have allowed their usage as risk indicators in the coronary circulation.…”

Section: Introductionmentioning

confidence: 99%

Exercise induced changes in T1, T2 relaxation times and blood flow in the lower extremities in healthy subjects

Varghese

Scandling

Ono

et al. 2013

Journal of Cardiovascular Magnetic Resonance

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Interleaved ³¹P MRS/¹H ASL for analysis of metabolic and functional heterogeneity along human lower leg muscles at 7T

Niess

Schmid

Bogner

et al. 2019

Magnetic Resonance in Med

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Purpose MR offers the unique possibility to noninvasively investigate cellular energy metabolism via 31P MRS, while blood perfusion, which provides oxygen and substrates to the tissue, is accessible by arterial spin labeling (ASL) 1H MRI. Because metabolic and hemodynamic parameters are linked, it would be desirable to study them simultaneously. A 3D‐resolved method is presented that allows such measurements with high spatiotemporal resolution and has the potential to discern differences along an exercising muscle. Methods Multi‐voxel localized 31P MRS was temporally interleaved with multi‐slice pASL 1H MRI. Phosphorus spectra were collected from two adjacent positions in gastrocnemius medialis (GM) during rest, submaximal plantar flexion exercise and recovery, while perfusion and T2*‐weighted axial images were acquired at the same time. Seventeen healthy volunteers (9 f / 8 m) were studied at 7 T. Results An increase of postexercise perfusion and T2*‐weighted signal in GM positively correlated with end‐exercise PCr depletion and pH drop. At proximal positions functional and metabolic activity was higher than distally, that is, perfusion increase and peak T2*‐weighted signal, end‐exercise PCr depletion, end‐exercise pH, and PCr recovery time constant were significantly different. An NOE‐induced SNR increase of approximately 20 % (P < .001), at rest, was found in interleaved 31P spectra, when comparing to 31P‐only acquisitions. Conclusions A technique for fast, simultaneous imaging of muscle functional heterogeneity in ASL, T2* and acquisition of time‐resolved 31P MRS data is presented. These single exercise recovery experiments can be used to investigate local variations during disease progression in patients suffering from vascular or muscular diseases.

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Peripheral Arterial Disease Assessment

Abstract: Introduction-Peripheral arterial disease (PAD) is characterized by lower limb arterial obstruction due to atherosclerosis and is increasingly common. Presently used methods for diagnosis and followup as well as for assessment of novel therapies are limited.

Cited by 14 publications

References 90 publications

Review of the adaptation of skeletal muscle in intermittent claudication

Review of the adaptation of skeletal muscle in intermittent claudication

Exercise induced changes in T1, T2 relaxation times and blood flow in the lower extremities in healthy subjects

Interleaved ³¹P MRS/¹H ASL for analysis of metabolic and functional heterogeneity along human lower leg muscles at 7T

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Peripheral Arterial Disease Assessment

Abstract: Introduction-Peripheral arterial disease (PAD) is characterized by lower limb arterial obstruction due to atherosclerosis and is increasingly common. Presently used methods for diagnosis and followup as well as for assessment of novel therapies are limited.

Cited by 14 publications

References 90 publications

Review of the adaptation of skeletal muscle in intermittent claudication

Review of the adaptation of skeletal muscle in intermittent claudication

Exercise induced changes in T1, T2 relaxation times and blood flow in the lower extremities in healthy subjects

Interleaved 31P MRS/1H ASL for analysis of metabolic and functional heterogeneity along human lower leg muscles at 7T

Contact Info

Product

Resources

About

Interleaved ³¹P MRS/¹H ASL for analysis of metabolic and functional heterogeneity along human lower leg muscles at 7T