Peripheral Arterial Disease in Patients With End-Stage Renal Disease

Rajagopalan, Sanjay; Dellegrottaglie, Santo; Furniss, Anna; Gillespie, Brenda W.; Satayathum, Sudtida; Lameire, Norbert; Saitō, Akira; Akiba, Takashi; Jadoul, Michel; Ginsberg, Nancy; Keen, Marcia L.; Port, Friedrich K.; Mukherjee, Debabrata; Saran, Rajiv

doi:10.1161/circulationaha.105.607390

Cited by 240 publications

(119 citation statements)

References 27 publications

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“…The relation between PAD and mortality persisted even after adjustment for age, gender, duration of dialysis, diabetes mellitus and smoking (OR, 1.575; 95% CI, 1.038-2.381; P = 0.033) [1]. These findings support the results of earlier studies showing that PAD is common in dialysis patients and that it is associated with increased cardiovascular morbidity and mortality rates in this population [2][3][4]. This Editorial discusses some additional aspects that may be of interest.…”

supporting

confidence: 83%

“…Thus, in dialysis patients, high vascular calcification scores on plain radiographs [7] or duplex ultrasonography of the lower limb arteries [17] may be more accurate predictors of PAD than the ABI. Due to the strong association between PAD and increased cardiovascular mortality rates in dialysis patients [1][2][3][4], the early detection of subclinical PAD in these patients is crucial. The early recognition of subclinical PAD will allow the timely initiation of preventive measures (e.g.…”

mentioning

confidence: 99%

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Screening for peripheral artery disease in dialysis patients: an opportunity for early disease detection and timely initiation of appropriate therapeutic measures

et al. 2011

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supporting

confidence: 83%

mentioning

confidence: 99%

Screening for peripheral artery disease in dialysis patients: an opportunity for early disease detection and timely initiation of appropriate therapeutic measures

et al. 2011

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“…Smoking, CLI, and age independently increased the risk for death (HR 2.3, 4.9, and 1.1, respectively). Smoking, besides other traditional cardiovascular risk factors, has been documented to be an independent risk factor for CAD and PAD in patients with ESRD (93). A crosssectional analysis of a random sample (n ϭ 4025) of incident patients with ESRD from the Dialysis Morbidity and Mortality Study, Wave 2, revealed that smokers had a 22% greater likelihood of having CAD than nonsmokers (94).…”

Section: Patients With Esrdmentioning

confidence: 99%

Smoking

Orth

Hallan²

2008

Clinical Journal of the American Society of Nephrology

256

174

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Although it is beyond any doubt that smoking is the number one preventable cause of death in most countries, smoking as an independent progression factor in renal disease has been questioned against the background of evidence-based criteria. This is because information from large, randomized, prospective studies that investigate the effects of smoking on renal function in healthy individuals as well as in patients with primary or secondary renal disease are lacking. Since 2003, a substantial number of clinical and experimental data concerning the adverse renal effects of smoking have been published, including large, prospective, population-based, observational studies. These more recent data together with evidence from experimental studies clearly indicate that smoking is a relevant risk factor, conferring a substantial increase in risk for renal function deterioration. This review summarizes the present knowledge about the renal risks of smoking as well as the increased cardiovascular risk caused by smoking in patients with chronic kidney disease. The conclusion is that smoking is an important renal risk factor, and nephrologists have to invest more efforts to motivate patients to stop smoking.

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“…4,5 Within the dialysis population this prevalence is much higher estimated at 28%. 6,7 Recently, ESRF which is defined as nonreversible kidney injury requiring renal replacement therapy 8,9 has been identified as a risk factor for PAD leading to non-healing foot ulcers and LLA. [10][11][12][13][14] Recent international studies have identified dialysis to be an independent risk factor for foot ulcers.…”

Section: Introductionmentioning

confidence: 99%

Non-traumatic lower limb amputation in patients with end-stage renal failure on dialysis: an Australian perspective

et al. 2016

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Background: End-stage renal failure (ESRF) and dialysis have been identified as a risk factor for lower limb amputations (LLAs). High rate of ESRF amongst the Australian population has been reported, however till date no study has been published identifying magnitude and risk factors of LLA in subjects on renal dialysis. Objective: The study aims to document trends in the prevalence and identify risk factors of nontraumatic LLA in Australian patients on dialysis. Methods: A retrospective review of all patients (218) ] p¼ 0.01). 75% of the amputees had aboriginal heritage. We also identified higher HbA1c and CRP levels as well as low serum albumin, hemoglobin and vitamin D levels to have a strong association with LLAs (p < 0.05). Conclusion: There is high prevalence of LLAs amongst Australian indigenous patients with diabetes on dialysis in North Queensland. Other strongly associated risk factors include history of foot ulceration, foot deformity and peripheral neuropathy as well as high HbA1c levels and low serum albumin levels.

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Peripheral Arterial Disease in Patients With End-Stage Renal Disease

Cited by 240 publications

References 27 publications

Screening for peripheral artery disease in dialysis patients: an opportunity for early disease detection and timely initiation of appropriate therapeutic measures

Screening for peripheral artery disease in dialysis patients: an opportunity for early disease detection and timely initiation of appropriate therapeutic measures

Smoking

Non-traumatic lower limb amputation in patients with end-stage renal failure on dialysis: an Australian perspective

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