Peripheral Artery Disease as a Manifestation of Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) and Practical Implications

Briceño, David; Bhattacharjee, Meenakshi B.; Supsupin, Emilio P; Navarro, Patricia; Bhattacharjee, Modushudan

doi:10.1161/circulationaha.112.000947

Cited by 7 publications

(5 citation statements)

References 4 publications

(5 reference statements)

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“…We read with interest the report from Briceno et al 1 Although we agree that the clinical presentation of their patient represents some diagnostic challenges, we question the author's conclusion that their patient suffered from cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and express our concern that some of the authors' considerations are potentially hazardous.…”

Section: To the Editormentioning

confidence: 90%

Letter by Dichgans et al Regarding Article, “Peripheral Artery Disease as a Manifestation of Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) and Practical Implications”

2013

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Section: To the Editormentioning

confidence: 90%

Letter by Dichgans et al Regarding Article, “Peripheral Artery Disease as a Manifestation of Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) and Practical Implications”

2013

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“…However, some CADASIL patients are still under-diagnosed because familial history is not always easily recognized or because of atypical presentation, such as primary intracerebral hemorrhage, peripheral artery disease and pontine microbleeds [4][5][6]. Furthermore, our previous work and several other studies revealed that migraine with aura and abnormal white matter in the temporal pole was less common, while brainstem involvement was more common in mainland Chinese patients than in Caucasians [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

The genetic spectrum and the evaluation of CADASIL screening scale in Chinese patients with NOTCH3 mutations

Xiao

Zuo

Sun

et al. 2015

Journal of the Neurological Sciences

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“…The clinical presentation of CADASIL may also vary depending on the sex of the affected individual; while migraines with aura are 50% more prevalent in women, stroke is 75% more prevalent in men [ 16 ]. Although the neurological manifestations of CADASIL are well described, the incidence of CAD in patients with CADASIL has not been fully studied [ 8 , 17 ]. This is mainly due to the infrequent incidence of these conditions and the lack of large registries.…”

Section: Epidemiologymentioning

confidence: 99%

“…This is mainly due to the infrequent incidence of these conditions and the lack of large registries. Published reports mostly consist of case reports and small case series ( Table 1 ) [ 6 , 8 , 9 , 10 , 11 , 12 ]. However, these reports suggest that CADASIL may play an important role in the pathogenesis and development of a severe and more aggressive and recurrent form of CAD [ 3 , 4 , 5 , 7 , 18 , 19 ].…”

Section: Epidemiologymentioning

confidence: 99%

Management of Coronary Artery Disease in CADASIL Patients: Review of Current Literature

et al. 2023

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Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common heritable form of vascular dementia in adults. It is well-established that CADASIL results in neurocognitive dysfunction and mood disturbance. There is also cumulative evidence that CADASIL patients are more susceptible to ischemic heart disease. The aim of this study is to review the current literature regarding the incidence of coronary artery disease in CADASIL patients with a focus on the various management options and the clinical challenges associated with each of these treatment strategies. We conducted a literature search using Cochrane, MEDLINE, and EMBASE for papers that reported the occurrence of coronary artery disease in patients with CADASIL. We supplemented the search with a manual search in Google Scholar. Only case reports, case series, and original articles were included. The search resulted in six reports indicating the association between coronary artery disease and CADASIL and its management. Evidence suggests that extracranial manifestations of CADASIL may include coronary artery disease, presenting as a more extensive burden of disease in younger patients. Surgical and percutaneous revascularization strategies are feasible, but the incidence of peri-procedural stroke remains significant and should be weighed against the potential benefit derived from either of these strategies. A multidisciplinary approach to therapy, with perspectives from neurologists, cardiologists, and cardiac surgeons, is needed to provide the appropriate treatment to the CADASIL patient with severe coronary artery disease. Future studies should be directed toward the development of targeted therapies that may help with the early detection and prevention of disease progress in these patients.

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Peripheral Artery Disease as a Manifestation of Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) and Practical Implications

Cited by 7 publications

References 4 publications

Letter by Dichgans et al Regarding Article, “Peripheral Artery Disease as a Manifestation of Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) and Practical Implications”

Letter by Dichgans et al Regarding Article, “Peripheral Artery Disease as a Manifestation of Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) and Practical Implications”

The genetic spectrum and the evaluation of CADASIL screening scale in Chinese patients with NOTCH3 mutations

Management of Coronary Artery Disease in CADASIL Patients: Review of Current Literature

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