Peripheral artery tonometry demonstrates altered endothelial function in children with type 1 diabetes

Haller, Michael J.; Stein, Jennifer; Shuster, J J; Theriaque, Douglas W.; Silverstein, Janet H.; Schatz, Desmond; Earing, Michael G.; Lerman, Amir; Mahmud, Farid H.

doi:10.1111/j.1399-5448.2007.00246.x

Cited by 121 publications

(105 citation statements)

References 25 publications

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“…22 Haller et al described a wide range of RHI in their cohort of children with type 1 diabetes (age 14.6±2.7 years): RHI was 1.63±0.5 when compared with children without diabetes (mean RHI 1.95±0.3, P<0.01). 3 Our values in the 14-year-olds were higher than in the diabetes group but lower than in the healthy group. As other studies have found comparable data (e.g., male diabetic subjects vs. controls (1.60±0.32 vs. 1.92±2.5), 2 we point out the necessity of considering the age and sex of the test persons.…”

Section: Factors Associated With Rhi: Clinical Aspectsmentioning

confidence: 84%

Endothelial Function in Children and Adolescents Is Mainly Influenced by Age, Sex and Physical Activity　― An Analysis of Reactive Hyperemic Peripheral Artery Tonometry ―

Mueller

Walther

Adam

et al. 2017

Circ J

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emic index (RHI)) of endothelial function in a 15-min test. 9 In adults, an RHI <1.35 indicates impaired endothelial function. 7 Data providing normal values for RHI in children and adolescents are limited. However, the method is used frequently for study purposes, usually to compare endothelial function in children with cardiovascular risk factors against healthy subjects. 2,3 Additionally, interventional studies investigating the effect of physical exercise (PE) on RHI in adolescents are lacking.Thus, using RH-PAT in a large cohort of healthy school children, we aimed to explore the factors influencing the RHI under particular consideration of PE at school. A

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Section: Factors Associated With Rhi: Clinical Aspectsmentioning

confidence: 84%

Endothelial Function in Children and Adolescents Is Mainly Influenced by Age, Sex and Physical Activity　― An Analysis of Reactive Hyperemic Peripheral Artery Tonometry ―

Mueller

Walther

Adam

et al. 2017

Circ J

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“…However, this is not possible in daily clinical (and of course scientific) practice due to the risk of hypertensive emergencies. Whether the PAT-ratio is a predictor of outcomes in more selected populations, such as patients with early coronary atherosclerosis 22) , obstructive sleep apnea 31) or pulmonary hypertension 32) and children with diabetes mellitus 33) ,…”

Section: Study Limitationsmentioning

confidence: 99%

Prognostic Value of Peripheral Arterial Tonometry in Patients with Coronary Artery Disease and a High Cardiovascular Risk Profile

Suessenbacher

Dörler

Wanitschek

et al. 2014

JAT

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Aim: Data regarding the prognostic value of peripheral endothelial function testing in patients with cardiovascular disease are conflicting. Peripheral arterial tonometry (PAT) is increasingly used to measure the peripheral endothelial function. The prognostic value of this method has not been investigated thus far in patients with cardiovascular disease and/or a high cardiovascular risk profile. Methods: In 96 patients with significant coronary artery disease (CAD) or ＜70% stenosis and ≥ three cardiovascular risk factors, reactive hyperemia was induced following upper arm occlusion and the PAT-ratio between baseline and hyperemia was calculated. The patients were followed for cardiovascular events (revascularization, acute coronary syndrome, ischemic stroke, cardiovascular death, repeat coronary angiography due to chest pain) for 44±14 months. The first event was included in the combined end point. Results: The study cohort was divided according to the median PAT-ratio (1.91). The combined end point occurred in 14 patients with a PAT-ratio below the median (1.91) and in 12 patients with a PAT-ratio of ≥ 1.91 (p= 0.65). In a subgroup of 76 patients, the PAT-ratio was reassessed after six months. No differences in the event rate were found between the patients who exhibited deterioration (n = 50) and those who exhibited an improvement in the PAT-ratio of ＞0.1 (n = 26; 22 vs. 32%, p = 0.32). The combined end point occurred earlier in the patients with a PAT-ratio within the 1st tertile than in those with a PAT-ratio within the 2nd/3rd tertile (11.3±11.0 vs. 27.5±18.6 months, p= 0.03). Conclusions: In patients with established CAD or a high cardiovascular risk profile, the PAT-ratio cannot be used to predict the risk of future cardiovascular events. However, a lower PAT-ratio may be associated with the earlier occurrence of cardiovascular events. J Atheroscler Thromb, 2014; 21:230-238.

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“…[84][85][86][87][88][89] For instance, RH-PAT results were significantly impaired in patients with exercise-induced myocardial ischemia. 87 More importantly, it is similar to FMD in representing a true physiological reflection of peripheral endothelial function, [90][91][92] and is particularly useful in conditions such as diabetes [93][94][95] or the metabolic syndrome 96,97 that impair endothelial function. RH-PAT results have also been found to correlate well with coronary endothelial function.…”

Section: Physiological Measurementsmentioning

confidence: 99%

Assessment of endothelial function in the patient with erectile dysfunction: an opportunity for the urologist

Tamler

Bar‐Chama

2008

Int J Impot Res

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Although there is now ample evidence that men with manifest coronary, cerebral and peripheral vascular disease and their risk factors are at highest risk for suffering from erectile dysfunction, recent findings demonstrate a strong connection between erectile dysfunction and endothelial dysfunction. This review explores how urologists and other providers may utilize the link between these conditions in clinical practice, compares methods of assessing endothelial dysfunction and finally speculates on how this additional information might impact treatment plans.

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Peripheral artery tonometry demonstrates altered endothelial function in children with type 1 diabetes

Cited by 121 publications

References 25 publications

Endothelial Function in Children and Adolescents Is Mainly Influenced by Age, Sex and Physical Activity　― An Analysis of Reactive Hyperemic Peripheral Artery Tonometry ―

Endothelial Function in Children and Adolescents Is Mainly Influenced by Age, Sex and Physical Activity　― An Analysis of Reactive Hyperemic Peripheral Artery Tonometry ―

Prognostic Value of Peripheral Arterial Tonometry in Patients with Coronary Artery Disease and a High Cardiovascular Risk Profile

Assessment of endothelial function in the patient with erectile dysfunction: an opportunity for the urologist

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Peripheral artery tonometry demonstrates altered endothelial function in children with type 1 diabetes

Cited by 121 publications

References 25 publications

Endothelial Function in Children and Adolescents Is Mainly Influenced by Age, Sex and Physical Activity ― An Analysis of Reactive Hyperemic Peripheral Artery Tonometry ―

Endothelial Function in Children and Adolescents Is Mainly Influenced by Age, Sex and Physical Activity ― An Analysis of Reactive Hyperemic Peripheral Artery Tonometry ―

Prognostic Value of Peripheral Arterial Tonometry in Patients with Coronary Artery Disease and a High Cardiovascular Risk Profile

Assessment of endothelial function in the patient with erectile dysfunction: an opportunity for the urologist

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Endothelial Function in Children and Adolescents Is Mainly Influenced by Age, Sex and Physical Activity　― An Analysis of Reactive Hyperemic Peripheral Artery Tonometry ―

Endothelial Function in Children and Adolescents Is Mainly Influenced by Age, Sex and Physical Activity　― An Analysis of Reactive Hyperemic Peripheral Artery Tonometry ―