Peripheral-Blood Dendritic Cells in Men With Coronary Heart Disease

Shi, Hongyu; Ge, Junbo; Fang, Weiyi; Yao, Kang; Sun, Aijun; Huang, Rongchong; Jia, Qingzhe; Wang, Keqiang; Zou, Yunzeng; Cao, Xuetao

doi:10.1016/j.amjcard.2007.03.067

Cited by 28 publications

(21 citation statements)

References 27 publications

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“…Some studies reported unchanged counts of pDCs in patients with coronary artery disease (CAD) (Shi et al, 2007) and myocardial infarction (MI) (Wen et al, 2013). Other researchers detected decreased numbers of pDCs in patients with troponin-positive unstable coronary artery syndromes (Van Vré et al, 2006), end-stage heart disease (Athanassopoulos et al, 2004), and advanced CAD (Yilmaz et al, 2009; Van Vré et al, 2010).…”

Section: Proinflammatory Activities Of Pdcs In Atherosclerosismentioning

confidence: 99%

Plasmacytoid dendritic cells: development, functions, and role in atherosclerotic inflammation

et al. 2014

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Plasmacytoid dendritic cells (pDCs) are a specialized subset of DCs that links innate and adaptive immunity. They sense viral and bacterial pathogens and release high levels of Type I interferons (IFN-I) in response to infection. pDCs were shown to contribute to inflammatory responses in the steady state and in pathology. In atherosclerosis, pDCs are involved in priming vascular inflammation and atherogenesis through production of IFN-I and chemokines that attract inflammatory cells to inflamed sites. pDCs also contribute to the proinflammatory activation of effector T cells, cytotoxic T cells, and conventional DCs. However, tolerogenic populations of pDCs are found that suppress atherosclerosis-associated inflammation through down-regulation of function and proliferation of proinflammatory T cell subsets and induction of regulatory T cells with potent immunomodulatory properties. Notably, atheroprotective tolerogenic DCs could be induced by certain self-antigens or bacterial antigens that suggests for great therapeutic potential of these DCs for development of DC-based anti-atherogenic vaccines.

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Section: Proinflammatory Activities Of Pdcs In Atherosclerosismentioning

confidence: 99%

Plasmacytoid dendritic cells: development, functions, and role in atherosclerotic inflammation

et al. 2014

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“…En sangre, los porcentajes de estas dos poblaciones celulares son muy bajos, aproximadamente, 0,22 % y 0,05 % de las células mononucleares, respectivamente (15).…”

Section: Biología De Las Células Dendríticasunclassified

Papel de las células dendríticas tolerogénicas ILT3+/ILT4+ en la respuesta inmunitaria a trasplante de órganos y tejidos

Arboleda¹,

García²,

Álvarez³

2011

biomedica

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Las células dendríticas son las células presentadores de antígeno más potentes y, por lo tanto, son importantes en el desencadenamiento de la respuesta inmunitaria frente a aloantígenos; sin embargo, también juegan un papel fundamental en el mantenimiento de la tolerancia periférica. La tolerancia es potenciada por la expresión en estas células de los receptores inhibidores ILT3 e ILT4, los cuales, mediante el reclutamiento de fosfatasas de tirosinas a sus dominios ITIM, inhiben la activación de la célula presentadora de antígeno y conducen a una débil respuesta de la célula T. Estos receptores propician, además, una interacción bidireccional con células T supresoras, T reguladoras o ambas, generando una cascada inmunorreguladora específica de antígeno, en la cual la célula dendrítica se comporta como una célula "tolerogénica". En esta revisión analizamos la biología y el comportamiento de las células dendríticas tolerogénicas que expresan altos niveles de ILT3 e ILT4, así como algunos aspectos moleculares y genéticos de estos receptores y su importancia en la modulación de las respuestas inmunitarias específicas de aloantígeno frente a un trasplante.Palabras clave: trasplante, células dendríticas, tolerancia inmunológica, inmunomodulación, supervivencia. ILT3 + /ILT4 + tolerogenic dendritic cells and their influence on allograft survivalDendritic cells, the most powerful antigen-presenting cells, are important for triggering of the immune responses to allo-antigens. However, they also play a fundamental role in the peripheral tolerance maintenance. Tolerance is enhanced by the presence on the dendritic cell surface of the inhibitor receptors ILT3 and ILT4. They recruit protein tyrosine-phosphatases to their ITIM domains and inhibit antigen-presenting cell activation, leading T cell hypo-responsivensess. Moreover, these receptors favor a bidirectional interaction with T-suppressor and T-regulator cells, generating an antigen-specific immunoregulator cascade, in which the dendritic cell behaves as a tolerogenic cell. In the current review, analysis is centered on the biology and behavior of the tolerogenic dendritic cells that express high levels of ILT3 and ILT4. Some molecular and genetics aspects of these receptors are discussed as well as their importance in the modulation of the allo-specific antigen immune response to transplants.

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“…30 In this study, there was no significant difference in the frequency of DCs between men and women.…”

Section: Discussionmentioning

confidence: 74%

High Ratio of Myeloid Dendritic Cells to Plasmacytoid Dendritic Cells in Blood of Patients With Acute Coronary Syndrome

Fukunaga

Soejima

Irie

et al. 2009

Circ J

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Peripheral-Blood Dendritic Cells in Men With Coronary Heart Disease

Cited by 28 publications

References 27 publications

Plasmacytoid dendritic cells: development, functions, and role in atherosclerotic inflammation

Plasmacytoid dendritic cells: development, functions, and role in atherosclerotic inflammation

Papel de las células dendríticas tolerogénicas ILT3+/ILT4+ en la respuesta inmunitaria a trasplante de órganos y tejidos

High Ratio of Myeloid Dendritic Cells to Plasmacytoid Dendritic Cells in Blood of Patients With Acute Coronary Syndrome

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