Peripheral blood-derived cytokine gene polymorphisms and metabolic profile in women with polycystic ovary syndrome

Sóter, Mirelle O.; Ferreira, Cláudia N.; Sales, Mariana F.; Cândido, Alexandre Luna; Reis, Fernando M.; Milagres, Kátia S.; Ronda, Carla R.S.C.; Silva, Ieda O.; Sousa, Marinez O.; Gomes, Karina Braga

doi:10.1016/j.cyto.2015.06.008

Cited by 20 publications

(21 citation statements)

References 66 publications

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“…The placental and decidual tissues in human from normal women express an array of pro- and anti-inflammatory cytokines (Roth et al, 1996, Piccinni et al, 1998). Low grade chronic inflammation and imbalance between pro- and anti-inflammatory cytokines have been proposed to play a role in the PCOS pathogenesis (Kelly et al, 2001, Sóter et al, 2015). …”

Section: Introductionmentioning

confidence: 99%

Interleukin 10 (− 1082 G/A) and (− 819 C/T) gene polymorphisms in Egyptian women with polycystic ovary syndrome (PCOS)

et al. 2016

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Cytokines play critical roles in the pathogenesis of Polycystic Ovarian Syndrome (PCOS). This work was designed to study the implication of IL10 gene polymorphisms (− 1082 G/A and − 819 C/T) on the susceptibility of Egyptian women to have PCOS. Rotterdam consensus criteria were used to diagnose PCOS patients. Genotyping was performed by single-stranded polymorphism-polymerase chain reaction (SSP-PCR) in 61 PCOS patients and 80 healthy controls, and IL-10 serum levels were measured using Enzyme linked immunosorbent assay (ELISA). The frequency of IL10 − 1082 G/G (46%) genotype was significantly increased (p < 0.001) while the frequency of − 1082 A/A (16%) genotype was significantly decreased (p < 0.05) in PCOS patients compared to controls (14% and 35% for G/G and A/A genotypes; respectively). G allele (65%) is significantly increased (p < 0.01( in PCOS patients while A allele (61%) is significantly increased (p < 0.001( in control subjects. The distribution of IL10 -819 T/T genotype was significantly increased (p < 0.05) in PCOS group. G/G genotype (odd ratio (OR = 5.322) with confidence interval (CI = 2.364–11.982) and the G allele (OR = 2.828 with CI = 1.73–4.61) of − 1082 G/A and T/T genotype of − 819 C/T (OR = 4.18 with CI = 1.26–13.86) could be considered as risk factors for PCOS. IL-10 levels were significantly lower among PCOS patients (313.42 ± 30.10) compared to normal controls (4914.36 ± 303.72). Depending on our preliminary work, IL10 − 1082 G/G might be considered as a host genetic factor for PCOS susceptibility in Egyptian women. Studies concerning other cytokine gene polymorphisms are required to get a better understanding of the pathogenesis of PCOS disease.

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Section: Introductionmentioning

confidence: 99%

Interleukin 10 (− 1082 G/A) and (− 819 C/T) gene polymorphisms in Egyptian women with polycystic ovary syndrome (PCOS)

et al. 2016

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“…In support of the direct relationship hypothesis, a potential role of T lymphocytes in the local pathological mechanisms of PCOS has been reported [29], and the TGF-β1 gene is thought to play a role in this process and to modulate the immune response. Although recent genetic studies have demonstrated that the TGF-β1 gene is associated with the development and clinical features of PCOS and that dysregulation in TGF-β signaling may contribute to the pathogenesis of PCOS [5][6][7]11], no compelling evidence exists for actual changes in TGF-β in the ovaries of patients with PCOS.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, inheritance patterns, characterized by complex polygenic traits, further complicate the identification of genetic factors. Genetic susceptibility studies of PCOS have focused on genes related to the metabolism of adipose tissue and steroid hormones and the release and action of gonadotropin and insulin and inflammatory cytokine genes [3][4][5][6][7][8]. However, it is difficult to establish which genes are involved due to a wide range Capsule This study demonstrates that TGF-β1 gene SNPs are associated with PCOS development (rs1800469 and rs4803457) and with PCOS characteristics in Korean women (rs1800469 and rs2317130), as assessed by laboratory and clinical measurements.…”

Section: Introductionmentioning

confidence: 99%

Single nucleotide polymorphisms in the TGF-β1 gene are associated with polycystic ovary syndrome susceptibility and characteristics: a study in Korean women

Roh

Yoon

Song

et al. 2016

J Assist Reprod Genet

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Purpose Although many hypotheses regarding the pathogenesis of polycystic ovary syndrome (PCOS) have been generated, genetic studies have not identified specific genes that play a role in PCOS etiopathogenesis. This study aimed to investigate the relationship between TGF-β1 gene polymorphism and PCOS in Koreans. Method A total of 51 Korean women with PCOS and 69 healthy women were enrolled. We analyzed 4 single nucleotide polymorphisms (SNPs) of the TGF-β1 gene (rs11466313, rs1800469, rs2317130, and rs4803457). We also analyzed laboratory measurements, such as free testosterone, glucose, and cholesterol. Results The frequencies of rs1800469T allele negativity, rs4803457T allele negativity, the rs1800469CC genotype, and the rs4803457CC genotype showed positive associations with PCOS (P = 0.003, P = 0.027, P = 0.009, and P=0.031, respectively), whereas the haplotypes rs1800469C-rs4803457T and rs1800469T-rs4803457T showed negative associations with PCOS. A strong protective effect of the Brs1800469CT-rs4803457TT^combination (OR = 0.09) and a strong risk effect of Brs1800469CC-rs4803457CC^(OR = 6.23) for PCOS were observed. The rs1800469C/T and rs2317130C/T SNPs exhibited associations with several laboratory measurements with various levels of significance. Conclusion The results demonstrated an association of TGF-β1 gene polymorphisms with the development and/or characteristics of PCOS in the Korean population.

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“…11 Some studies including a study by Soter et al, 12 have demonstrated a definite influence of interleukin-6 and interleukin-10 gene polymorphisms, interferon-c and transforming growth factor-beta1 in the development of PCOS, although no clear pattern of inheritance has been identified. 12 Other causal factors are epigenetic exposures, highlighting the association between intrauterine exposure and maternal androgens and phenotypes related to the syndrome.…”

Section: Etiology and Pathophysiologymentioning

confidence: 99%

“…12 Other causal factors are epigenetic exposures, highlighting the association between intrauterine exposure and maternal androgens and phenotypes related to the syndrome. 13 Ethnic variations in PCOS may be associated with environmental factors, such as socioeconomic conditions and lifestyle.…”

Section: Etiology and Pathophysiologymentioning

confidence: 99%

Current aspects of polycystic ovary syndrome: A literature review

Andrade

Mata

Borges³

et al. 2016

Rev. Assoc. Med. Bras.

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Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder with variable prevalence, affecting about one in every 15 women worldwide. The diagnosis of polycystic ovary syndrome requires at least two of the following criteria: oligoovulation and/or anovulation, clinical and/or biochemical evidence of hyperandrogenism and morphology of polycystic ovaries. Women with PCOS appear to have a higher risk of developing metabolic disorders, hypertension and cardiovascular disorders. The aim of this article was to present a review of the literature by searching the databases Pubmed and Scielo, focusing on publications related to polycystic ovaries, including its pathogenesis, clinical manifestations, diagnosis and therapeutic aspects, as well as its association with cardiovascular and arterial hypertensive disorders.

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Peripheral blood-derived cytokine gene polymorphisms and metabolic profile in women with polycystic ovary syndrome

Cited by 20 publications

References 66 publications

Interleukin 10 (− 1082 G/A) and (− 819 C/T) gene polymorphisms in Egyptian women with polycystic ovary syndrome (PCOS)

Interleukin 10 (− 1082 G/A) and (− 819 C/T) gene polymorphisms in Egyptian women with polycystic ovary syndrome (PCOS)

Single nucleotide polymorphisms in the TGF-β1 gene are associated with polycystic ovary syndrome susceptibility and characteristics: a study in Korean women

Current aspects of polycystic ovary syndrome: A literature review

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