Peripheral blood eosinophilia and eosinophil accumulation in coronary microvessels in acute Kawasaki disease

Terai, Masaru; Yasukawa, Kumi; Honda, Takafumi; Jibiki, Toshiaki; Hirano, K; Sato, Junichi; Ishiwada, Naruhiko; Seguchi, Masashi; Ueda, Shiro; Kohno, Yoichi

doi:10.1097/00006454-200208000-00015

Cited by 55 publications

(56 citation statements)

References 16 publications

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“…The exact mechanism of eosinophilia was not clearly understood in KD (10). However, eosinophilia in the acute stage of KD was suggested to be associated with an underlying allergic disease or immune response (6,10). In our study, mild increase of eosinophil rate and the count was present nearly in more than 80% of the KD patients with PBE and one patient who developed giant CAA had severe eosinophilia (20%).…”

Section: Discussionmentioning

confidence: 45%

“…Previous studies regarding eosinophilia in KD cases have included cKD cases and to our knowledge this is the first attempt to study eosinophil measurements in iKD patients (6,10,11). The etiology of eosinophilia includes a large number of diseases including vasculitis (Churg-Strauss, helminthic infections, atopic diseases, drug ingestion) (8).…”

Section: Discussionmentioning

confidence: 99%

“…However, some authors have already described the presence of eosinophils in coronary microvessel lesions (6,7) and increased peripheral blood eosinophilia in the acute stage of a complete form of KD (cKD) previously (6).…”

Section: Introductionmentioning

confidence: 99%

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An observational study on peripheral blood eosinophilia in incomplete Kawasaki disease

Öner¹,

Yılmazer²,

Güven³

et al. 2012

Anadolu Kardiyol Derg

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Objective: To investigate the peripheral blood eosinophilia (PBE) in the acute stage of incomplete Kawasaki disease (iKD). Methods: Twenty-four patients with iKD (median age; 31.5 months, range; 7-88 months) and 25 with complete Kawasaki disease (cKD) (median age; 37 months, range; 9-140 months) were evaluated between 2004 and 2010 from İzmir Dr. Behçet Uz Children's Hospital records retrospectively. We determined the eosinophil counts and rates from the complete blood count in two study groups before the IVIG treatment and 30 febrile age-matched controls and 30 control cases with congenital heart disease (control Group 1 and 2 respectively). Kruskal-Wallis test was performed in detecting the differences of eosinophil rates and counts between four subgroups. Results: In iKD group, the mean value of eosinophil rates and median value of eosinophil counts were 4.39±2.5% and 377 cells/mm 3 , respectively, which did not significantly different with cKD group (mean eosinophil rates; 5.47±4.8% and median eosinophil counts 525 cells/mm 3 ) (p>0.05). The median values of eosinophil cell counts and mean value of eosinophil rates were 220 cell/mm 3 and 2.83±2.65% in the control group 1 and 165 cell/mm 3 and 1.63±1.43% in the control Group 2 respectively, which were statistically significant lower compared to both study groups (p< 0.001). Conclusion: The rate of PBE was found significantly higher in iKD patients compared to the controls. Since the diagnosis of iKD is difficult, unexplained eosinophilia may be helpful in the presence of suggestive clinical findings of KD. (Anadolu Kardiyol Derg 2012; 12: 160-4) Key words: Kawasaki disease, incomplete, eosinophilia 160 ÖZET Amaç: İnkomplet Kawasaki hastalığı'nın (iKD) akut evresinde periferik kan eozinofilisinin (PKE) araştırılması amaçlandı. Yöntemler: Yirmi dört iKD (ortanca yaş; 31.5 ay, yaş aralığı; 7-88 ay) ve 25 komplet Kawasaki Hastalığı (kKD) tanılı hasta (ortanca yaş; 37 ay, yaş aralığı; 9-140 ay), 2004-2010 yılları arasında İzmir Dr. Behçet Uz Çocuk Hastanesi kayıtlarından retrospektif olarak değerlendirildi. Çalışmaya yaş olarak çalışma grubu ile uyumlu, ateşi olan 30 vaka (kontrol 1) ile konjenital kalp hastalıklı 30 vaka (kontrol 2) kontrol grubu olarak dahil edildi ve kontrol, çalışma grupları eozinofil yüzdeleri ve eozinofil hücre sayıları açsısından IVIG tedavisi öncesinde karşılaştırıldı. Kontrol ve çalışma grupları arasındaki eozinofil farklılıklarını saptamada Kruskal-Wallis testi kullanıldı. Bulgular: İnkomplet Kawasaki hastalarında PKE görülme yüzdesi ve ortalama değeri sırasıyla %66.6 ve 377 hücre/mm 3 iken cKD grubunda ise sırasıyla; %60 ve 525 hücre/mm 3 idi ve iki grup arasında her iki değer açısından da anlamlı fark saptanmadı (p>0.05). Eozinofil hücre sayısının ortanca değeri ile eozinofili yüzdesinin ortalama değeri sırasıyla 1. kontrol grubunda 220 hücre/mm 3 ve %2.83±2.65 iken 2.kontrol grubunda ise 165 hücre/mm 3 ve %1.63±1.43 idi, ve bu değerler çalışma grubunda saptananlara göre istatistiksel anlamlı olarak düşüktü (p<0.001). Sonuç: Ko...

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Section: Discussionmentioning

confidence: 45%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

An observational study on peripheral blood eosinophilia in incomplete Kawasaki disease

Öner¹,

Yılmazer²,

Güven³

et al. 2012

Anadolu Kardiyol Derg

View full text Add to dashboard Cite

show abstract

“…In patients with Kawasaki disease, an increased risk of allergy has been noted by several groups [31][32][33], supported by a possible skewing into a Th2 profile by mRNA expression [34,35]. Moreover, in blood as well as urine, eosinophils can be detected compared to febrile control patients [36,37]. Finally, in autopsy material the coronary lesions obtained from deceased patients show infiltration of CCR3-positive cells such as eosinophils and macrophages [37].…”

Section: Discussionmentioning

confidence: 88%

“…Moreover, in blood as well as urine, eosinophils can be detected compared to febrile control patients [36,37]. Finally, in autopsy material the coronary lesions obtained from deceased patients show infiltration of CCR3-positive cells such as eosinophils and macrophages [37]. This was a reason to study the impact of SNPs in the CCR3 gene located at chromosome 3p21 in close proximity to the CCR2-CCR5 gene cluster (Fig.…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms in chemokine receptor genes and susceptibility to Kawasaki disease

Breunis

Biezeveld

Geissler

et al. 2007

Clinical and Experimental Immunology

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SummaryKawasaki disease (KD) is an acute vasculitis occurring in young children. Its aetiology is unknown, but an infectious agent is assumed. Increased levels of proinflammatory cytokines and chemokines have been reported in KD. Genetic variation in these genes and the receptors for these genes could influence the regulation of cytokines and chemokines. In a case-control study of 170 Dutch Caucasian KD patients and 300 healthy Dutch Caucasian controls, common genetic variants in chemokine receptor genes CCR3, CCR2, CCR5, CX3CR1, CXCR1 and CXCR2 were analysed. Of the eight studied single nucleotide polymorphisms (SNPs) in the CCR3-CCR2-CCR5 gene cluster, four showed a significant association with susceptibility to KD. Moreover the CCR5-D32 was observed with an allele frequency of 10·7% in the control population compared to 6·5% in the KD patients (P = 0·04). Two haplotypes of the CCR3-CCR2-CCR5 gene-cluster appear to be at risk haplotypes for KD and one a protective haplotype. No association was observed with the studied SNPs in CX3CR1, CXCR1 and CXCR2. In conclusion, in a Dutch cohort of KD patients an association of KD occurrence with common genetic variants in the chemokine receptor gene-cluster CCR3-CCR2-CCR5 was observed.

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Kawasaki Disease

2007

Deadly Dermatologic Diseases

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Peripheral blood eosinophilia and eosinophil accumulation in coronary microvessels in acute Kawasaki disease

Abstract: Because the numbers of circulating eosinophils in the body are tightly regulated, eosinophil accumulation in blood or tissues may reflect the host's immune response against KD related antigen(s).

Cited by 55 publications

References 16 publications

An observational study on peripheral blood eosinophilia in incomplete Kawasaki disease

An observational study on peripheral blood eosinophilia in incomplete Kawasaki disease

Polymorphisms in chemokine receptor genes and susceptibility to Kawasaki disease

Kawasaki Disease

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