2005
DOI: 10.1002/ijc.20998
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Peripheral blood IFN‐γ‐secreting Vα24+Vβ11+ NKT cell numbers are decreased in cancer patients independent of tumor type or tumor load

Abstract: Natural killer T (NKT) cells are CD1d-restricted lymphoid cells and are characterized by an invariant T-cell receptor, which in humans consists of a Va24 chain paired with a Vb11 chain. These cells are known for their rapid production of large amounts of cytokines (e.g., Vb11+ NKT cell numbers in both healthy controls and cancer patients and demonstrate that in both groups females have higher NKT cell levels compared to males. In a large group of 120 cancer patients, we show that circulating Va24+ NKT cell n… Show more

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Cited by 200 publications
(177 citation statements)
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“…As NKT cell numbers and function are reduced in many cancer patients, 40,41 including those with breast cancer, 41 the effectiveness of endogenous NKT activation could be limited. Therefore, we examined whether adoptive transfer of expanded NKT cells in combination with NKT cell activation would enhance therapeutic outcome in our mice.…”
Section: Glycolipid Treatments Reduce Metastasismentioning
confidence: 99%
“…As NKT cell numbers and function are reduced in many cancer patients, 40,41 including those with breast cancer, 41 the effectiveness of endogenous NKT activation could be limited. Therefore, we examined whether adoptive transfer of expanded NKT cells in combination with NKT cell activation would enhance therapeutic outcome in our mice.…”
Section: Glycolipid Treatments Reduce Metastasismentioning
confidence: 99%
“…Therapeutic activation of iNKT cells in murine models can prevent tumor growth [182][183][184], ameliorate autoimmune [185,186] and metabolic [187] disease, and protect against microbial infection [188]. Numerical and functional iNKT cell deficiencies have been reported in a number of human diseases [189][190][191][192]. These findings led to clinical trials in humans for cancer involving the adoptive transfer of ex vivo expanded autologous DC, pulsed with a-GC, in the absence or presence of expanded iNKT cells [193][194][195].…”
Section: Priming Of Cd4 + and Cd8 + T Cells By Vc9/vd2 T Cells: A Newmentioning
confidence: 99%
“…In humans, a reduction in the number of circulating iNKT cells is accompanied by a striking Th1 polarization in certain autoimmune diseases such as type 1 diabetes, systemic sclerosis and rheumatoid arthritis [18][19][20][21]. Cancer patients have decreased numbers of iNKT cells in their blood and impaired in vitro proliferative potential, reversible with IL-2 [22][23][24]. As well as the reduced numbers of these cells found in many cancer patients, there is a striking reversal of cytokine polarization relative to that found in diabetes, which may reflect a reduction in iNKT anti-tumor activity during progression [22,25].…”
Section: Introductionmentioning
confidence: 99%