Peripheral blood lymphocyte/monocyte ratio as a useful prognostic factor in dogs with diffuse large B-cell lymphoma receiving chemoimmunotherapy

Marconato, Laura; Martini, Valeria; Stefanello, Damiano; Moretti, Pierangelo; Ferrari, R.; Comazzi, S.; Laganga, Paola; Riondato, Fulvio; Aresu, Luca

doi:10.1016/j.tvjl.2015.07.009

Cited by 46 publications

(95 citation statements)

References 29 publications

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“…Surprisingly, when WBCC, NC, NLR were considered together in the Cox regression model, only WBCC remained prognostic for LR, while NLR and NC lost their significance. This finding is in contrast with previous reports in human and canine oncology . Indeed, NLR and other leukocyte ratios reportedly have higher prognostic impact than leukocyte counts due to their greater stability and lower susceptibility to fluctuations of single cell populations caused by pathophysiological changes .…”

Section: Discussioncontrasting

confidence: 94%

“…This finding is in contrast with previous reports in human and canine oncology . Indeed, NLR and other leukocyte ratios reportedly have higher prognostic impact than leukocyte counts due to their greater stability and lower susceptibility to fluctuations of single cell populations caused by pathophysiological changes . Since NLR takes into account both the impact of variations of NC and LC, the fact that NLR was inferior in predicting LR may be due to the lack of significance of LC: inclusion of this variable in the ratio may have reduced the prognostic significance of NLR.…”

Section: Discussioncontrasting

confidence: 78%

“…In human medicine, higher values of pretreatment NLR have been correlated with poorer prognosis for several solid malignancies, including STS . The prognostic/diagnostic value of different leukocyte populations, such as neutrophils, lymphocytes, eosinophils, and monocytes, and their ratios has been explored in canine solid and lymphoproliferative neoplasms . In a recent paper, NLR was significantly higher in dogs with STS than in those with benign soft tissue lesions, although the parameter was not predictive of tumour grade .…”

Section: Discussionmentioning

confidence: 99%

“…A few papers have explored the prevalence of different leukocyte populations and T‐lymphocyte subsets in tumour‐bearing vs healthy dogs . Furthermore, leukocyte counts and ratios have been proposed as diagnostic and prognostic tools for dogs with lymphoma, osteosarcoma, mast cell tumours and STS . Yet, the prognostic impact of peripheral leukocyte counts and ratios, including NLR, has not been assessed in feline medicine.…”

Section: Introductionmentioning

confidence: 99%

“…[23][24][25][26] Furthermore, leukocyte counts and ratios have been proposed as diagnostic and prognostic tools for dogs with lymphoma, osteosarcoma, mast cell tumours and STS. [27][28][29][30][31] Yet, the prognostic impact of peripheral leukocyte counts and ratios, including NLR, has not been assessed in feline medicine. Given the promising results described in canine oncology, this retrospective study aimed to explore the prognostic impact on LR of pretreatment white blood cell count (WBCC), neutrophil count (NC), lymphocyte count (LC) and NLR in cats with newly diagnosed, surgically excised FISS.…”

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confidence: 99%

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Evaluation of leukocyte counts and neutrophil‐to‐lymphocyte ratio as predictors of local recurrence of feline injection site sarcoma after curative intent surgery

Chiti

Martano

Ferrari

et al. 2019

Vet Comparative Oncology

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Local recurrence (LR) is the major concern in the treatment of feline injection‐site sarcoma (FISS). Pretreatment leukocyte counts and ratios have been reported as diagnostic and/or prognostic markers in human and canine oncology. The aim of this retrospective study was to explore the prognostic impact on LR and overall survival time (OST) of pretreatment neutrophil‐to‐lymphocyte ratio (NLR), white blood cell count (WBCC), neutrophil count (NC) and lymphocyte count (LC) in cats with surgically excised FISS. Eighty‐two cats with histologically confirmed FISS at first presentation, without distant metastases, and with available pretreatment haematological analyses were retrospectively enrolled. The correlation of NLR, WBCC, NC, LC with tumour variables and patient variables was explored. NLR was correlated with tumour size (P = .004), histological pattern of tumour growth (P = .024) and histotype (P = .029), while WBCC and NC were associated with ulceration (P = .007, P = .011) and pattern of growth (P = .028, P = .004). No significant relationships emerged between LC and any of the considered variables. The impact of NLR, WBCC, NC, LC on LR and OST was then estimated in univariate and multivariate analysis. In univariate analysis, NLR, WBCC and NC were significant prognostic factors for both LR and OST. NLR, WBCC and NC remained prognostic in multivariate analysis for LR but not for OST. When NLR, WBCC and NC were jointly analysed, WBCC was the marker with the greater impact on LR. Preoperative NLR, WBCC and NC may aid in identifying cats at higher risk of LR.

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Section: Discussioncontrasting

confidence: 94%

Section: Discussioncontrasting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Evaluation of leukocyte counts and neutrophil‐to‐lymphocyte ratio as predictors of local recurrence of feline injection site sarcoma after curative intent surgery

Chiti

Martano

Ferrari

et al. 2019

Vet Comparative Oncology

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Multi‐modal Therapy

Banks¹,

Mullin²,

Clifford³

2022

Veterinary Surgical Oncology

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Analytical variability and uncertainty in canine leukocyte ratios obtained with manual counts

et al. 2022

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Background This study aimed to determine the analytical imprecision of calculated neutrophil to lymphocyte (NLR) and lymphocyte to monocyte ratios generated from manual differential white blood cell (WBC) counts in peripheral blood smears, and to describe how to report the uncertainty around a single WBC ratio result. No information on the analytical imprecision of WBC ratios in dogs is available. Methods Coefficient of variations (CVs) of paired readings of one operator on 105 smears (intraoperator variability) and of three operators on 301 smears (interoperator variability) were calculated. The interoperator agreement was examined with the Fleiss’ kappa coefficient (κ). Observed total errors (TEos), expanded measurement of uncertainty (EMU) and reporting intervals (RIs) were also calculated. Results Median CVs ranged from 3.14 to 28.28 (intraoperator) and from 5.39 to 53.85 (interoperator). No agreement among operators was found around the cut‐offs. TEos were higher than allowable total errors in 32%–88% of smears. EMU ranged from 0.10 to 1.13. According to the RI, the calculated WBC ratios should be rounded to the nearest 10. Conclusion WBC ratios should be interpreted cautiously in dogs. The EMU should be reported to make the clinician aware of the uncertainty of these parameters. For example, an NLR result of 17 is needed to have high confidence that the result is above a cut‐off of 6.

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Peripheral blood lymphocyte/monocyte ratio as a useful prognostic factor in dogs with diffuse large B-cell lymphoma receiving chemoimmunotherapy

Cited by 46 publications

References 29 publications

Evaluation of leukocyte counts and neutrophil‐to‐lymphocyte ratio as predictors of local recurrence of feline injection site sarcoma after curative intent surgery

Evaluation of leukocyte counts and neutrophil‐to‐lymphocyte ratio as predictors of local recurrence of feline injection site sarcoma after curative intent surgery

Multi‐modal Therapy

Analytical variability and uncertainty in canine leukocyte ratios obtained with manual counts

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