Peripheral Blood MicroRNAs as Potential Biomarkers of Myocardial Damage in Acute Viral Myocarditis

Abstract

Background: microRNAs (miRs) have emerged as important modulators of cardiovascular development and disease. Our aim was to determine whether cardiac-related miRs such as miR-21-5p and miR-1-3p were differentially expressed in acute viral myocarditis and whether any of them was related with the extent of myocardial damage and left ventricular dysfunction. Methods: We enrolled 40 patients with acute viral myocarditis. Blood samples were taken on admission and miRs expression levels in peripheral blood mononuclear cells were quantified by real-time reverse transcription polymerase chain reaction. Results: miR-21-5p, miR-1-3p were significantly elevated in acute myocarditis. miR-21-5p levels showed a strong correlation with global longitudinal strain (r = 0.71, p < 0.01), while miR-1-3p had significant correlations with troponin I (r = 0.79, p < 0.01). Conclusions: The expression of miR-21-5p and miR-1-3p in peripheral blood is increased in acute viral myocarditis, and this increase is correlated with myocardial damage and indicative of left ventricular systolic dysfunction in these patients.

lncRNA ADAMTS9-AS1/circFN1 Competitively Binds to miR-206 to Elevate the Expression of ACTB, Thus Inducing Hypertrophic Cardiomyopathy

“…Moreover, inhibition of miR-145-5p was previously shown to protect cardiac dysfunction after cardiac arrest and resuscitation [23]. Lastly, studies have also documented increased expressions of miR-1-3p in peripheral blood of patients with acute viral myocarditis and further associated with myocardial injury [24], left ventricular end diastolic diameter (LVEDD), and left ventricular ejection fraction (LVEF) reflecting cardiac function of HCM [25]. Furthermore, evidence also suggests miR-1-3p is also associated with hypertrophy and fibrosis in HCM [26].…”

Exosomal Non-Coding RNA Mediates Macrophage Polarization: Roles in Cardiovascular Diseases

“…For example, miR-92a is found to be associated with the development of DCM, acute MI, CAD, and AS and is a potential diagnostic marker of these diseases [156][157][158][159]. miR-21-5p can be a great candidate for indicating acute MI [160] and acute viral myocarditis [161] etc. In addition, miR-181b is identified as a potential circulating biomarker for heart failure-associated inflammation [162] and diabetic cardiomyopathy [163].…”

A systematic review of miRNAs as biomarkers for chemotherapy-induced cardiotoxicity in breast cancer patients reveals potentially clinically informative panels as well as key challenges in miRNA research

“…miR-1 influences the inflammatory cytokinase response through modulating KLF4 and NF-κB pathways as well as the TGF-β signalling pathway. miR-1 has been associated with a variety of cardiovascular conditions including: acute myocardial infarction [36][37][38][39][40][41], sudden cardiac death [42], microvascular obstruction leading to failed myocardial reperfusion [43], acute viral myocarditis [44], hypertrophic cardiomyopathy [45,46], idiopathic dilated cardiomyopathy [47], hypertrophic obstructive cardiomyopathy patients undergoing trans-coronary ablation of septal hypertrophy (TASH) [48], the congenital heart malformation Tetralogy of Fallot [49], stress-related Takotsubo cardiomyopathy [50], hypertensive heart disease [51], geriatric patients with acute non-ST elevation myocardial infarction (NSTEMI) [52], acute coronary syndrome [53] and post-operative atrial fibrillation of coronary artery bypass patients [54,55]. In contrast to upregulation of miR-1 in all of these cardiovascular conditions, consistent downregulation of miR-1 has been noted in heart failure [56][57][58], which indicates a diversity of roles of this microRNA in the process of cardiac injury.…”