Peripheral blood oxidative stress markers for obstructive sleep apnea—a meta-analysis

Hu, Yuzhui; Lin, Min; Luo, Jingying; Shi, Wensong; Xiang, Hui; Song, Sijia; Hong, Liuyan; Long, Wenting; Mo, Biwen; Luo, Miao

doi:10.1007/s11325-021-02557-z

Cited by 8 publications

(6 citation statements)

References 56 publications

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“…Inflammatory state is reported for pathological conditions resulting from intermittent hypoxia in humans with OSA ( 43 , 86 , 87 ) and dogs presenting with BOAS ( 12 , 37 , 39 ). The missing differences in the CRP concentrations between BC and NC dogs in our study may reflect differences in study designs.…”

Section: Discussionmentioning

confidence: 99%

“…Our list of the selected parameters of interest included the common red blood cell indices, complete blood cell count, and clinical blood biochemistry, as well as the parameters that were shown to be affected in blood of human patients with obstructive sleep apnea (OSA). They include plasma NO derivatives ( 42 ) and oxidative stress markers such as non-protein and total reduced thiols and methemoglobin ( 43 ). As the potential screening parameters should not be affected by blood sample transportation from the site of withdrawal (e.g., dog show) to the lab, we also investigated the tentative impact of shipment on some of the most informative parameters.…”

Section: Introductionmentioning

confidence: 99%

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Differences in selected blood parameters between brachycephalic and non-brachycephalic dogs

et al. 2023

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IntroductionCranial and upper-airway anatomy of short-nosed, flat-faced brachycephalic dogs predisposes them to brachycephalic obstructive airway syndrome (BOAS). Periodic apnoea increased inspiratory resistance, and an inability to thermoregulate effectively are characteristic of BOAS, but internationally accepted objective markers of BOAS severity are missing. The objective of this study was to compare the selected blood parameters between non-brachycephalic (NC) and brachycephalic (BC) dogs, exploring the possibility of developing a blood test for BOAS severity grading in the future.MethodsWe evaluated blood biochemistry, complete blood cell counts, red blood cell (RBC) indices, reticulocyte counts, a blood-born marker of intermittent hypoxia (glutathione, NO production), RBC hydration, deformability, and blood markers of metabolic changes and stress between BC (n = 18) and NC (meso- and dolichocephalic, n = 22) dogs.ResultsReticulocyte counts and the abundance of middle-fluorescence immature reticulocytes were significantly (p < 0.05) higher in BC dogs compared to NC dogs. BC dogs had significantly more NO-derived NO2-/NO3- in plasma than NC dogs. RBCs of BC dogs were shedding significantly more membrane, as follows from the intensity of eosin maleimide staining, and had a significantly higher mean corpuscular hemoglobin concentration than NC dogs. Intracellular reduced glutathione content in RBCs of BC dogs was significantly lower, while plasma lactate was significantly higher in BC dogs compared to NC dogs. Plasma cholesterol and triglycerides were significantly lower, and cortisol was significantly higher in BC dogs compared to NC dogs. Eosinophil counts were significantly lower and the neutrophil-to-lymphocyte ratio was higher in BC dogs compared to NC dogs.DiscussionTaken together, our findings suggest that the brachycephalic phenotype in dogs is associated with alterations at the level of blood cells and, systemically, with oxidation and metabolic changes. The parameters identified within this study should be further investigated for their potential as objective indicators for BOAS.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Differences in selected blood parameters between brachycephalic and non-brachycephalic dogs

et al. 2023

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“…OSA is a typical pathological condition characterized by increased oxidative stress. Studies have measured and compared levels of thiobarbituric acid reactive substances in the blood [ 19 , 20 ] and 8-hydroxyguanosine in the urine [ 21 , 22 ] as biomarkers for OSA. However, no unified opinion currently exists on the changes in their levels, and an appropriate and practical diagnostic marker has yet to be discovered for OSA.…”

Section: Discussionmentioning

confidence: 99%

Hyperoxidized Peroxiredoxin 2 Is a Possible Biomarker for the Diagnosis of Obstructive Sleep Apnea

et al. 2022

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Peroxiredoxin (Prx) 2 in red blood cells (RBCs) reacts with various reactive oxygen species and changes to hyperoxidized Prx2 (Prx2-SO2/3). Therefore, Prx2 may serve as an indicator of oxidative stress in vivo. This study aimed to analyze Prx2-SO2/3 levels in clinical samples to examine whether the oxidation state of Prx2 in human RBCs reflects the pathological condition of oxidative stress diseases. We first focused on obstructive sleep apnea (OSA), a hypoxic stress-induced disease of the respiratory system, and investigated the levels of Prx2-SO2/3 accumulated in the RBCs of OSA patients. In measurements on a small number of OSA patients and healthy subjects, levels of Prx2-SO2/3 accumulation in patients with OSA were clearly increased compared to those in healthy subjects. Hence, we proceeded to validate these findings with more samples collected from patients with OSA. The results revealed significantly higher levels of erythrocytic Prx2-SO2/3 in patients with OSA than in healthy subjects, as well as a positive correlation between the severity of OSA and Prx2-SO2/3 levels in the RBCs. Moreover, we performed a chromatographic study to show the structural changes of Prx2 due to hyperoxidation. Our findings demonstrated that the Prx2-SO2/3 molecules in RBCs from patients with OSA were considerably more hydrophilic than the reduced form of Prx2. These results implicate Prx2-SO2/3 as a promising candidate biomarker for OSA.

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“…Other nonlipoprotein biomarkers of metabolic syndrome are summarized in Table 2[83–90,91 ▪ ,92,93–100,101 ▪ ,102,103–107].…”

Section: Novel Cardiovascular Risk Factors and Metabolic Syndromementioning

confidence: 99%

Established and potential cardiovascular risk factors in metabolic syndrome: Effect of bariatric surgery

Bashir,

Adam,

et al. 2023

Current Opinion in Lipidology

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Purpose of review The aim of this study was to provide an overview of the role of novel biomarkers in metabolic syndrome, their association with cardiovascular risk and the impact of bariatric surgery on these biomarkers. Recent findings Metabolic syndrome encompasses an intricate network of health problems, and its constituents extend beyond the components of its operational definition. Obesity-related dyslipidaemia not only leads to quantitative changes in lipoprotein concentration but also alteration in qualitative composition of various lipoprotein subfractions, including HDL particles, rendering them proatherogenic. This is compounded by the concurrent existence of obstructive sleep apnoea (OSA) and nonalcoholic fatty liver disease (NAFLD), which pave the common pathway to inflammation and oxidative stress culminating in heightened atherosclerotic cardiovascular disease (ASCVD) risk. Bariatric surgery is an exceptional modality to reverse both conventional and less recognised aspects of metabolic syndrome. It reduces the burden of atherosclerosis by ameliorating the impact of obesity and its related complications (OSA, NAFLD) on quantitative and qualitative composition of lipoproteins, ultimately improving endothelial function and cardiovascular morbidity and mortality. Summary Several novel biomarkers, which are not traditionally considered as components of metabolic syndrome play a crucial role in determining ASCVD risk in metabolic syndrome. Due to their independent association with ASCVD, it is imperative that these are addressed. Bariatric surgery is a widely recognized intervention to improve the conventional risk factors associated with metabolic syndrome; however, it also serves as an effective treatment to optimize novel biomarkers.

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Peripheral blood oxidative stress markers for obstructive sleep apnea—a meta-analysis

Cited by 8 publications

References 56 publications

Differences in selected blood parameters between brachycephalic and non-brachycephalic dogs

Differences in selected blood parameters between brachycephalic and non-brachycephalic dogs

Hyperoxidized Peroxiredoxin 2 Is a Possible Biomarker for the Diagnosis of Obstructive Sleep Apnea

Established and potential cardiovascular risk factors in metabolic syndrome: Effect of bariatric surgery

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