Peripheral Blood Smear Findings in COVID-19

Ahnach, Maryame; Ousti, Fadwa; Nejjari, S.; Houssaini, Mohammed Sqalli; Dini, N.

doi:10.4274/tjh.galenos.2020.2020.0262

Cited by 18 publications

(32 citation statements)

References 6 publications

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“…Maryame et al found neutrophil granulocyte with dysmorphic morphology marked by hypogranular cytoplasm and hyposegmented nucleus, atypical eosinophils containing multiple vacuoles, rare, activated lymphocytes, and large monocytes in some peripheral blood films in COVID-19 patients. 23 They did not show any association of these changes with the clinical course of the disease. In this study, we observed a large number of dysplasia, hypolobular, hypergranular neutrophils, and a small number of hypogranular neutrophils.…”

Section: Discussionmentioning

confidence: 89%

Simple Peripheral Blood Smear Findings of Covid-19 Patients Provide Information About the Severity of the Disease and the Duration of Hospital Stay.

Berber

Çağaşar

Sarıcı

et al. 2020

Mediterr J Hematol Infect Dis

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Backround Data about the morphological changes of Covid-19 infection in peripheral blood smear are limited and association with clinical severity of the disease are not known yet. We aimed to examine the characteristics of the cells detected in the pathological rate and / or appearance and whether these findings are related to the clinical course by evaluating the peripheral blood smear at the time of diagnosis in Covid-19 patients. Methods Clinical features, laboratory data, peripheral blood smear of fifty patients diagnosed with Covid-19 by PCR was evaluated at diagnosis. Peripheral smear samples of the patients were compared with the age and sex matched 30 healthy controls. Pictures were taken from the paitients’peripheral blood smear. Patients were divided into two groups. Early and advanced stage patient groups were compared in terms of laboratory data and peripheral smear findings. The relationship between the laboratory values of all patients and the duration of hospitalization was analyzed. Results Pseudo pelger-huet, atypical lymphocytes, vacuole monocytes and pycnotic neutrophils rates were high in the patient group. Increased pseudo pelger-huet anomaly, psodo-pelger huet/mature lymphocyte ratio, decreased number of mature lymphocytes, and eosinophils in peripheral blood smear were observed in the advanced stage patients (p <0.05). A negative correlation was observed between the duration of hospitalization and mature lymphocyte, and monocytes with vacuoles rates (p <0.05). Conclusion Peripheral smear is a cheap, easily performed, and rapid test. Increased pseudo-pelger huet anomaly/mature lymphocytes rate is suggesting advanced stage disease, while high initial monocytes with vacuoles and mature lymphocyte rates at the time of diagnosis may be an indicator of shortened duration of hospitalization.

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Section: Discussionmentioning

confidence: 89%

Simple Peripheral Blood Smear Findings of Covid-19 Patients Provide Information About the Severity of the Disease and the Duration of Hospital Stay.

Berber

Çağaşar

Sarıcı

et al. 2020

Mediterr J Hematol Infect Dis

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“… hypergranular cytoplasm (dark, crowded, “toxic” type) 49,64 presence of small basophilic, agranular cytoplasmic areas 49 hypogranular cytoplasm 49,65 blue‐green cytoplasmic inclusions in six patients who all died, in neutrophils and monocytes, probably derived from lipid‐rich lipofuscin from necrotic liver cells 64 nuclear hyposegmentation, sometimes with apoptotic chromatin, 1 or C‐shaped, fetus‐like or ring‐shaped nuclei or nuclear detachment 61 absence of nuclear segmentation (pseudo Pelger‐Huet nuclei), with liquefied chromatin 49 apoptotic neutrophils in the circulation 1,48,49 ; disintegrated or smudged neutrophils 57 Myeloid left shift and immature granulocytes in peripheral blood in the form of increased proportion of band cells, 49 metamyelocytes, myelocytes and promyelocytes or even blast with cytoplasmic granules 49,57,62 …”

Section: Discussionmentioning

confidence: 99%

The hematology laboratory’s response to the COVID‐19 pandemic: A scoping review

Bell

Zini

D’Onofrio

et al. 2020

Int J Lab Hematology

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The ongoing COVID‐19 pandemic has had a profound worldwide impact on the laboratory hematology community. Nevertheless, the pace of COVID‐19 hematology‐related research has continued to accelerate and has established the role of laboratory hematology data for many purposes including disease prognosis and outcome. The purpose of this scoping review was to assess the current state of COVID‐19 laboratory hematology research. A comprehensive search of the literature published between December 1, 2019, and July 3, 2020, was performed, and we analyzed the sources, publication dates, study types, and topics of the retrieved studies. Overall, 402 studies were included in this scoping review. Approximately half of these studies (n = 202, 50.37%) originated in China. Retrospective cohort studies comprised the largest study type (n = 176, 43.89%). Prognosis/ risk factors, epidemiology, and coagulation were the most common topics. The number of studies published per day has increased through the end of May. The studies were heavily biased in favor of papers originating in China and on retrospective clinical studies with limited use of and reporting of laboratory data. Despite the major improvements in our understanding of the role of coagulation, automated hematology, and cell morphology in COVID‐19, there are gaps in the literature, including biosafety and the laboratory role in screening and prevention of COVID‐19. There is a gap in the publication of papers focused on guidelines for the laboratory. Our findings suggest that, despite the large number of publications related to laboratory data and their use in COVID‐19 disease, many areas remain unexplored or under‐reported.

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“…We would like to share our ideas on the recently published letter entitled “Peripheral Blood Smear Findings in COVID-19” [ 1 ]. Ahnach et al [ 1 ] reported several observations and concluded that “Our preliminary results remain limited and more investigation is required to study the reversibility of these abnormalities and their impact on severity. Compared to all inflammatory biomarkers, observation of blood cells can be a simple alternative for the first triage and early identification of the infection” [ 1 ].…”

Section: To the Editormentioning

confidence: 99%

“…Ahnach et al [ 1 ] reported several observations and concluded that “Our preliminary results remain limited and more investigation is required to study the reversibility of these abnormalities and their impact on severity. Compared to all inflammatory biomarkers, observation of blood cells can be a simple alternative for the first triage and early identification of the infection” [ 1 ]. We agree that blood cell changes might be different in coronavirus disease-19 (COVID-19) patients with different stages of disease and severity.…”

Section: To the Editormentioning

confidence: 99%

“…Regarding platelets, thrombocytopenia is a common problem and decreased platelet counts should be seen in peripheral blood smears [ 2 ]. Finally, there is another point that Ahnach et al [ 1 ] did not mention. There might also be some underlying diseases or concurrent disorders in COVID-19 patients that could result in blood cell abnormalities.…”

Section: To the Editormentioning

confidence: 99%

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