2024
DOI: 10.21203/rs.3.rs-3924681/v1
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Peripheral blood TCRβ repertoire, IL15, IL2 and soluble ligands for NKG2D activating receptor predict efficacy of ICI in lung cancer

Andrea Sesma,
Julián Pardo,
Dolores Isla
et al.

Abstract: The development of immune checkpoints inhibitors (ICIs) has changed the therapeutic paradigm of lung cancer (LC), becoming the standard of treatment for previously untreated advanced non-small cell lung cancer (NSCLC) without actionable mutations. It has allowed the achievement of durable responses and resulted in significant survival benefits. However, not all patients respond, hence molecular biomarkers are needed to help us predict which patients will respond. With this objective, a prospective observationa… Show more

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