Peripheral calcifying cystic odontogenic tumour of the maxillary gingiva

Abstract

BackgroundOdontogenic tumors are lesions that are derived from remnants of the components of the developing tooth germ. The calcifying cystic odontogenic tumor or calcifying odontogenic cyst is a benign cystic neoplasm of odontogenic origin that is characterized by an ameloblastoma-like epithelium and ghost cells. Calcifying cystic odontogenic tumor may be centrally or peripherally located, and its ghost cells may exhibit calcification, as first described by Gorlin in 1962. Most peripheral calcifying cystic odontogenic tumors are located in the anterior gingiva of the mandible or maxilla.Case presentationAuthors report a rare case of a peripheral calcifying cystic odontogenic tumor of the maxillary gingiva. A 39-year-old male patient presented with a fibrous mass on the attached buccal gingiva of the upper left cuspid teeth. It was 0.7-cm-diameter, painless and it was clinically diagnosed as a peripheral ossifying fibroma. After an excisional biopsy, the diagnosis was peripheric calcifying cystic odontogenic tumor. The patient was monitored for five years following the excision, and no recurrence was detected.ConclusionsAll biopsy material must be sent for histological examination. If the histological examination of gingival lesions with innocuous appearance is not performed, the frequency of peripheral calcifying cystic odontogenic tumor and other peripheral odontogenic tumors may be underestimated.

Histologic Variants of Calcifying Odontogenic Cyst: A Study of 52 Cases

“…The WHO classified COC as a neoplasm and used the term calcifying cystic odontogenic tumor (CCOT) for benign cystic type, the DGCT for the benign solid type lesions which occur centrally or peripherally, and the malignant ghost cell odontogenic carcinoma. [2][3][4][5] The most common histopathological findings include a cystic lesion lined by epithelium with a well-defined basal layer of columnar cells, an overlying layer with many cells resembling stellate reticulum, and masses of ghost epithelial cells that may be in the epithelial cyst lining or in the fibrous capsule. The ghost epithelial cells may become calcified.…”

Calcifying cystic odontogenic tumour manifesting in the maxillary antrum: Case report

“…Intraoperatively the main challenge entailed clinically differentiating tumour lining from the normal paranasal lining tissues in some areas. Fortunately, as has been described in the literature [1,4] the cystic lining of the tumour tends to be uniformly thick and, therefore, easy to separate from the normal tissues.…”

“…Generally, benign odontogenic neoplasms are relatively rare lesions that are derived from either the epithelial and mesenchymal components or the remnant elements of the developing tooth germs. These lesions are often classified according to location as peripheral or central entities [1][2][3][4]. In this category of diseases, the calcifying cystic odontogenic tumour (CCOT) is a particularly rare benign entity that is characterized by an ameloblastoma-like epithelium and ghost cells that have the potential to undergo calcification [4][5][6].…”

“…These lesions are often classified according to location as peripheral or central entities [1][2][3][4]. In this category of diseases, the calcifying cystic odontogenic tumour (CCOT) is a particularly rare benign entity that is characterized by an ameloblastoma-like epithelium and ghost cells that have the potential to undergo calcification [4][5][6]. The lesion usually appears as a painless, slow-growing tumour that may involve the maxilla or mandible in the anterior segments [1,3].…”

A multicentre study of 268 cases of calcifying odontogenic cysts and a literature review

“…This was the same age distribution observed by Brazilian researchers in 2016 (Chrcanovic & Gomez, ). Most individuals complain of painless swelling (Buchner et al., ; Resende, Brito, Souza, Gomez, & Mesquita, ), and the clinical appearance of these lesions was variously described as sessile, nodular, smooth‐surfaced, firm, of soft consistency or as a fibrous mass (Buchner et al., ; de Lima, Kitakawa, Almeida, Brandão, & Anbinder, ; Resende et al., ). The erosion of the underlying alveolar bone was not so commonly seen in peripheral COC (Chrcanovic & Gomez, ).…”