Peripheral dentinogenic ghost cell tumor in the mandibular anterior region

Miyamoto, Shô; Hasegawa, Hiromasa; Tamaki, Tomoko; Matayoshi, Akira; Goto, Takahiro; Shirakawa, Jumpei; Goto, Shimpei; Nakasone, Toshiyuki; Wada, Naoki; Nakamura, Hiroyuki

doi:10.1016/j.ajoms.2022.01.005

Cited by 2 publications

(2 citation statements)

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“…WHO classification of odontogenic tumors in 2005 adopted and defined DGCT as a locally invasive neoplasm characterized by ameloblastoma‐like islands of epithelial cells with ghost cells and dentinoid in mature connective tissue stroma. As far as we are aware, the number of published cases that fulfilled the histopathological criteria of DGCTp is only 56 2,6–8 . Clinical features of DGCT and GCOC are summarized in the supplementary table based on data from de Souza Vieira et al 2 The present case showed almost typical profile of DGCTp.…”

Section: Discussionmentioning

confidence: 68%

“…As far as we are aware, the number of published cases that fulfilled the histopathological criteria of DGCTp is only 56. 2,[6][7][8] Clinical features of DGCT and GCOC are summarized in the supplementary table based on data from de Souza Vieira et al 2 The present case showed almost typical profile of DGCTp. Tumor size of DGCTp ranged from 0.3 to 3.0 cm (mean: about 1.5 cm), smaller than that of the central lesion (about 4.8 cm).…”

Section: Pathological Findingsmentioning

confidence: 76%

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Ghost cell odontogenic carcinoma arising in dentinogenic ghost cell tumor, peripheral: A case report

Sakamoto

Ando

Mizuta

et al. 2023

Pathology International

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Ghost cell odontogenic carcinoma (GCOC) is an extremely rare intraosseous malignant odontogenic tumor with prominent ghost cell keratinization and dentinoid formation. Here, we present the first case of GCOC arising in dentinogenic ghost cell tumor (DGCT), peripheral. The patient was a man in his 60s with an exophytic mass in the anterior part of lower gingiva. The resected tumor measured 4.5 cm in maximum diameter. Histologically, the nonencapsulated tumor proliferated in the gingiva without bone invasion. It was predominantly composed of ameloblastoma‐like nests and islands of basaloid cells with ghost cells and dentinoid in the mature connective tissue, suggesting DGCT, peripheral. As minor components, sheets of atypical basaloid cells and ameloblastic carcinoma‐like nests with pleomorphism and high proliferative activity (Ki‐67 labeling index up to 40%) consistent with malignancy were identified. CTNNB1 mutation and β‐catenin nuclear translocation were observed in both benign and malignant components. Final diagnosis was GCOC arising in DGCT, peripheral. GCOC shows similar histological features to DGCT. In this unique case without invasion, the cytological atypia and high proliferative activity supports the diagnosis of malignant transformation from DGCT.

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Section: Discussionmentioning

confidence: 68%