Peripheral distribution of presynaptic sites of abdominal motor and modulatory neurons inManduca sexta larvae

Consoulas, Christos; Johnston, Rebecca M.; Pflüger, Hans‐Joachim; Levine, Richard B.

doi:10.1002/(sici)1096-9861(19990719)410:1<4::aid-cne2>3.0.co;2-w

Cited by 24 publications

(15 citation statements)

References 77 publications

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“…OCT release has been demonstrated to occur from insect neuronal preparations in response to both electrical-and K + -induced depolarization (Morton and Evans, 1984;Orchard and Lange, 1987;Verlinden et al, 2010a), with typical neurotransmitter-like exocytotic release from synaptic vesicles (Consoulas et al, 1999). Released TYR and OCT are primarily removed from the synaptic cleft by dedicated transporter systems TAAR10a Serotonin TAAR10b TRP TAAR12h PEA, isoamylamine TAAR12i 3-MT TAAR13a Histamine TAAR13c Cadaverine TAAR13d Putrescine, histamine, cadaverine, agmatine TAAR13e Agmatine TAAR14d Agmatine TAAR16c N-methylpiperidine, N-methylpyrrolidine TAAR16e N,N-dimethylcyclohexylamine TAAR16f Isoamylamine…”

Section: B Storage and Releasementioning

confidence: 99%

“…Although a number of effects were observed, this second phase of studies in vertebrates stalled due to the lack of a selective receptor target through which the observed effects could be mediated. In contrast, TYR and OCT were established as bona fide invertebrate neurotransmitters during the same time period, with selective receptors identified (Morton and Evans, 1984;Roeder and Gewecke, 1989;Han et al, 1998;Consoulas et al, 1999). Thus, by the early 1990s, trace amine research was essentially restricted to invertebrate systems.…”

Section: Introductionmentioning

confidence: 99%

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Trace Amines and Their Receptors

Gainetdinov¹,

Hoener²,

Berry³

2018

Pharmacol Rev

300

287

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Section: B Storage and Releasementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Trace Amines and Their Receptors

Gainetdinov¹,

Hoener²,

Berry³

2018

Pharmacol Rev

300

287

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“…Using labeled OCT, it has been shown that OCT is released by depolarization through high potassium concentration or electrical stimulation. [78][79][80][81][82] Once OCT is released into the extracellular space, it binds to its postsynaptic receptors to elicit a physiological response. However, OCT release in the cytosol and reuptake is regulated by the presence of two types of transporters, ie, the transporter that carries OCT into secretory vesicles for storage by endocytosis and the transporter that mediates the reuptake of OCT following exocytosis.…”

Section: Release Reuptake and Enzymatic Inactivationmentioning

confidence: 99%

Review of octopamine in insect nervous systems

Farooqui¹

2012

OAIP

148

155

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Octopamine (OCT) belongs to a group of compounds known as biogenic amines. OCT, a monohydroxylic analog of norepinephrine, is found in both vertebrate and invertebrate nervous systems. OCT is present in relatively high concentrations in the neuronal and nonneuronal tissues of most invertebrate species studied. However, OCT occurs as a trace amine in vertebrates where its physiological significance remains uncertain. OCT acts as a neurotransmitter, neuromodulator, and neurohormone in insect nervous systems where it prominently influences multiple physiological events. In the peripheral nervous system, OCT modulates the activity of flight muscles, peripheral organs, and most sense organs. In the central nervous system, OCT is essential for the regulation of motivation, desensitization of sensory inputs, arousal, initiation, and maintenance of various rhythmic behaviors, hygiene behavior, and complex social behaviors, including establishment of labor, as well as learning and memory. As a neurotransmitter, OCT regulates endocrine gland activity and controls the emission of light in the firefly lantern. As a neurohormone, OCT is released into hemolymph, transported to target tissues, and induces mobilization of lipids and carbohydrates, preparing insects for a period of extended activity or assisting recovery from a period of increased energy demand. OCT modulates hemocytic nodulation in nonimmune larvae and enhances phagocytosis as a neurohormone. OCT exerts its effects by binding to specific receptors belonging to the superfamily of G protein-coupled receptors and shares the structural motif of seven transmembrane domains. Activation of octopaminergic receptor types is coupled with different second messenger pathways depending on the species, tissue source, receptor type, and cell line used for expression of the cloned receptor. OCT-mediated generation of second messengers is associated with changes in cellular response, affecting insect behaviors. This review describes the roles of OCT in insect nervous systems at the behavioral and molecular levels.

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“…Biocytin (Sigma, St Louis, MO, USA) was used for filling towards peripheral targets and was labeled with TRITCconjugated streptavidin (Jackson ImmunoResearch Laboratories), following the methods of Consoulas et al (1999). The filling period was 1-2·days at approximately 5°C.…”

Section: Neuronal Tracingmentioning

confidence: 99%

Localization of myoinhibitory peptide immunoreactivity inManduca sextaandBombyx mori, with indications that the peptide has a role in molting and ecdysis

Davis

Blackburn²,

Golubeva³

et al. 2003

Journal of Experimental Biology

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For normal development of Manduca sexta larvae, the ecdysteroid titer must drop following its sudden rise at the start of the molting cycle; this sudden decline in titer may be due to myoinhibitory peptide I (MIP I), which has an inhibitory effect on the release of ecdysone by the prothoracic glands of Bombyx mori in vitro. Using an antiserum to MIP, we have demonstrated secretion of an MIP-like peptide by the epiproctodeal glands of Manduca sexta, which are located on each proctodeal nerve, just anterior to the rectum. These MIP-immunoreactive glands are also present in B. mori. In fourth-instar larvae of M. sexta, the epiproctodeal glands show a distinct cycle of synthesis and sudden release of MIP that coincides with the time of the rapid decline in ecdysteroid titer. The function of the epiproctodeal glands appears to be the timely release of MIP during the molting cycle, so as to inhibit the prothoracic glands and thus to facilitate the sudden decline in ecdysteroid titer. In addition, we have found that MIP immunoreactivity is co-localized with that of crustacean cardioactive peptide (CCAP) in the 704 interneurons; these peptides appear to be co-released at the time of ecdysis. It is known that CCAP can initiate the ecdysis motor program; our results suggest that MIP may also be involved in activating ecdysis behavior.

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Peripheral distribution of presynaptic sites of abdominal motor and modulatory neurons inManduca sexta larvae

Cited by 24 publications

References 77 publications

Trace Amines and Their Receptors

Trace Amines and Their Receptors

Review of octopamine in insect nervous systems

Localization of myoinhibitory peptide immunoreactivity inManduca sextaandBombyx mori, with indications that the peptide has a role in molting and ecdysis

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