2009
DOI: 10.1016/j.neuroscience.2009.08.012
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Peripheral estradiol induces temporomandibular joint antinociception in rats by activating the nitric oxide/cyclic guanosine monophosphate signaling pathway

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Cited by 20 publications
(22 citation statements)
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“…Chronic neuronal iNOS inhibition decreased nociception in chronic carrageenan‐induced TMD in rats (Tesser‐Viscaino et al, ). In contrast to the study by Kishimoto et al (), blocking NO synthesis by administration of nitro‐1‐arginine in the TMJ blocked the antinociceptive effect of high physiologic estradiol, as did the inhibition of the guanylate cyclase activity (Favaro‐Moreira, Torres‐Chavez, Fischer, & Tambeli, ). On the other hand, nonphysiologic doses of estrogen given to OVX rats injected with CFA dose dependently upregulated expression of pro‐inflammatory iNOS and repressed M2‐associated genes such as IL‐10 and arginase (Kou et al, ).…”
Section: High Physiologic Concentrations Of Estrogen Leads To Reducedcontrasting
confidence: 79%
“…Chronic neuronal iNOS inhibition decreased nociception in chronic carrageenan‐induced TMD in rats (Tesser‐Viscaino et al, ). In contrast to the study by Kishimoto et al (), blocking NO synthesis by administration of nitro‐1‐arginine in the TMJ blocked the antinociceptive effect of high physiologic estradiol, as did the inhibition of the guanylate cyclase activity (Favaro‐Moreira, Torres‐Chavez, Fischer, & Tambeli, ). On the other hand, nonphysiologic doses of estrogen given to OVX rats injected with CFA dose dependently upregulated expression of pro‐inflammatory iNOS and repressed M2‐associated genes such as IL‐10 and arginase (Kou et al, ).…”
Section: High Physiologic Concentrations Of Estrogen Leads To Reducedcontrasting
confidence: 79%
“…ICI 182780 as well as acute inhibition of either nitric oxide synthase or guanylate cyclase eliminates antinociceptive effects of estradiol applied directly to the TMJ [67]. This confirms mediation of estradiol antinociceptive effects via a non-genomic membrane-generated second messenger mechanism.…”
Section: Plasma Membrane Ers and Nociception/antinociceptionmentioning
confidence: 74%
“…It has been reported that 17␤-E 2 delivered directly into the temporomandibular joint of anesthetized OVX rats reduced the nocifensive response (rubbing and flinching) to intrajoint injection of formalin measured over 45 min (Fá varo-Moreira et al, 2009). A nongenomic mechanism was suggested on the basis of the effectiveness of a membrane-impermeable form of 17␤-E 2 (conjugated to BSA).…”
Section: Discussionmentioning
confidence: 99%
“…Estrogen receptors (ERs) are expressed in nociceptors of the trigeminal ganglia (TG) and dorsal root ganglia (DRG) (Yang et al, 1998;Bereiter et al, 2005), and treatment with 17␤-estradiol (17␤-E 2 ) influences a variety of functions and cellular processes in nociceptors such as expression of trkA mRNA (Liuzzi et al, 1999), expression of calcitonin generelated peptide mRNA and protein (Gangula et al, 2000), extracellular signal-regulated kinase activity (Liverman et al, 2009), calcium mobilization (Chaban and Micevych, 2005), and transient receptor potential cation channel V1 (TRPV1) function (Xu et al, 2008). Furthermore, local 17␤-E 2 injection into the temporomandibular joint reduces nociceptive behavioral responses to intrajoint administration of formalin (Fá varo-Moreira et al, 2009), suggesting estrogen's effect on nociceptors is functionally relevant.…”
Section: Introductionmentioning
confidence: 99%