Peripheral ghrelin reduces food intake and respiratory quotient in chicken

Geelissen, Sofie; Swennen, Quirine; Geyten, Serge Van der; Kühn, Eduard; Kaiya, Hiroyuki; Kangawa, Kenji; Decuypere, Eddy; Buyse, Johan; Darras, Veerle

doi:10.1016/j.domaniend.2005.06.005

Cited by 93 publications

(43 citation statements)

References 22 publications

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“…Toshinai et al (2001) reported that plasma ghrelin levels increased during 12-h fasting and returned to the basal concentration after re-feeding. The current study demonstrated an increase in ghrelin mRNA expression and peptide concentration in proventriculus after 24 h fasting similar to the previous results reported by Geelissen et al (2006). Furthermore, we observed an increase in ghrelin concentration in homogenates from pituitary and adrenal glands.…”

Section: Discussionsupporting

confidence: 80%

“…Additionally, this effect was completely blocked by CRH receptor antagonist (astressin) injection what suggests that central ghrelin may interact with HPA axis (Saito et al, 2005). In poultry, the impact of ghrelin administered peripherally produced controversial results from having no effects (Kaiya et al, 2007) to inhibiting (Geelissen et al, 2006) or stimulating (Shousha et al, 2005) feed intake.…”

Section: Introductionmentioning

confidence: 99%

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Peripheral ghrelin inhibits feed intake through hypothalamo-pituitary-adrenal axis-dependent mechanism in chicken

Ocłoń¹,

Pietras²

2011

J. Anim. Feed Sci.

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It is known that centrally injected ghrelin is an anorexigenic peptide in chicken. Its activity is not mediated by NPY/AgRP -producing neurons but through the corticosterone releasing hormone (CRH) -expressing neurons in hypothalamus which activate the hypothalamo-pituitary-adrenal (HPA) axis inducing an increase in plasma corticosterone levels. However, controversial results of peripheral ghrelin effect on appetite have been reported. Thus, the influence of intraperitonealinjected ghrelin on the activity of the HPA axis in Cobb broiler chickens was examined. In addition, the effect of glucocorticoids antagonist (RU486) on the ghrelin activity was also investigated. The intraperitoneal co-injection of CRH-receptor antagonist, astressin, partially attenuated ghrelininduced anorexia and corticosterone release. Co-administration of RU486 significantly enhanced the inhibitory effect of ghrelin on feed intake in 7-day-old broiler chickens. These results indicate that the peripheral ghrelin -induced anorexia is caused by the stimulation of HPA axis in chickens.

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Section: Discussionsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Peripheral ghrelin inhibits feed intake through hypothalamo-pituitary-adrenal axis-dependent mechanism in chicken

Ocłoń¹,

Pietras²

2011

J. Anim. Feed Sci.

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“…This result is in accordance with Shousha et al (21), who reported that an increased dosage of peripheral ghrelin decreases feed intake in Japanese quail. In addition, our findings are in agreement with Geelissen et al (6) and Lotfi et al (14) who reported that infusion of exogenous ghrelin may cause decreased feed intake and improved FCR in broiler chickens.…”

Section: Discussionsupporting

confidence: 83%

“…Some studies (4,18) have revealed that central-injection of ghrelin inhibits food intake in chickens. Studies have indicated that the peripheral ghrelin in broiler chickens has an inhibitory effect on feed intake (3,6,17), whereas this effect has not been shown in layer chickens, as other species of birds (10). Interestingly, in a study on Japanese quail conducted by Shousha et al (21), infusion of peripheral (exogenous) ghrelin caused an increase in feed intake, whereas central (endogenous) ghrelin may inhibit feeding.…”

Section: Introductionmentioning

confidence: 99%

Effects of peripheral ghrelin on growth performance, selected blood biochemical parameters and thyroid hormone in Japanese quail (Coturnix coturnix japonica)

Shahryar¹,

Habib²,

Lotfi³

et al. 2018

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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Summary:The aim of present study was to investigate the effects of peripheral administration of ghrelin on performance and some serum parameters of Japanese quail. One hundred twenty 21 day-old male Japanese quails were divided into three groups for a 35 days experimental rearing period. The control group (G0) included no injection as an intact, the second group (treatment 1/G50) received 50 ng ghrelin/kg body weight (BW), and the third group (treatment 2/G100) was given 100 ng ghrelin/kg BW. Ghrelin was administrated (I. P. administration) at the onset of the experimental rearing period on 21-day old birds. Blood samples were taken at two different times: 1) 12 hrs after the injection, and; 2) at the end of the rearing period (on day 35). The effects of ghrelin were evaluated during experimental rearing periods. There were no changes in feed intake and body weight gain (BWG) following ghrelin administration at different dosages (50 or 100 ng/ kg BW), whereas a minor decrease in feed intake was observed in G100 group. Feed conversion ratio (FCR) is significantly decreased in G50 and G100, compared to control (P<0.05). Thyroxin (T4) was increased in ghrelin-administered groups in both samples (short/long-term). In conclusion, ghrelin administration in Japanese quails may improve FCR, and stimulate secretion of thyroid hormones, without severe effects on feed intake. However, it did not have considerable effects on carcass characteristics and serum biochemical measures in short and long-terms in Japanese quails.

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“…The amino acid levels are related to the regulation of intake by means of serotonin, ghrelin and gastric inhibitory peptide; such hormones involve tryptophan in their synthesis mechanism (Tsiolakis and Marks, 1984;Zhang et al, 2007). Variations of the plasmatic levels interfered with the standard consumption of swine and birds, as reported by Geelissen et al (2006).…”

Section: Performance Of Broiler Chickensmentioning

confidence: 99%

Poultry offal meal in broiler chicken feed

Silva

Rabello

Lima

et al. 2014

Sci. agric. (Piracicaba, Braz.)

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An outstanding feature of poultry production that provides animal protein yield for human feeding is its short production cycle. This characteristic has a linear relationship with waste production. Increasing the inclusion of this residue in diets in the near future is desirable in step with the growth of poultry production since it offers a better environmental and nutritional alternative to current methods. We evaluated the effects on the performance and carcass characteristics of broiler chickens produced by the inclusion of poultry offal meal (POM) in their feed. Treatments consisted of a control diet (corn, Zea mays and soybean, Glycine max) and four diets with inclusion of 30, 60, 90 and 120 g kg -1 of POM. The diets were formulated based on the level of digestible amino acid once categorized as isocalcic, isophosphoric, isosodic, isoenergetic and isonutritive for protein, methionine+cystine, lysine and threonine. The feed's electrolytes were corrected so that each diet had the same electrolytic balance. The variables analyzed were feed intake, weight gain, feed conversion ratio, body weight, carcass yield, chicken cut yield and abdominal fat.

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Peripheral ghrelin reduces food intake and respiratory quotient in chicken

Cited by 93 publications

References 22 publications

Peripheral ghrelin inhibits feed intake through hypothalamo-pituitary-adrenal axis-dependent mechanism in chicken

Peripheral ghrelin inhibits feed intake through hypothalamo-pituitary-adrenal axis-dependent mechanism in chicken

Effects of peripheral ghrelin on growth performance, selected blood biochemical parameters and thyroid hormone in Japanese quail (Coturnix coturnix japonica)

Poultry offal meal in broiler chicken feed

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