Peripheral giant cell granuloma

Tandon, Padam Narayan; Gupta, Shruti; Gupta, Divender; Jurel, Sunit Kumar; Saraswat, Abhishek

doi:10.4103/0976-237x.95121

Cited by 45 publications

(48 citation statements)

References 17 publications

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“…Previously, the lesion was called peripheral giant cell reparative granuloma. However, its reparative effect has not been proved yet, hence osteoclast activity seems doubtful (11,20,34) .…”

Section: Peripheral Giant Cell Lesionsmentioning

confidence: 99%

“…As it has been demonstrated by immunohistochemistry, giant cells have membrane receptors for calcitonin, which characterizes osteoclast activity. Another possibility is that they are formed by mononuclear cells from the phagocytic system (11,20,34) .…”

Section: Peripheral Giant Cell Lesionsmentioning

confidence: 99%

“…It is a well-defined lesion with exophytic growth. Additionally, it may be pedunculated, sessile or it may not present areas of ulceration (2,11,12,20,27,31,34) . It may develop at any age, predominantly in the first to sixth decade of life, especially from 31 to 41 years of age.…”

Section: Peripheral Giant Cell Lesionsmentioning

confidence: 99%

“…They may also be observed in areas of mature or immature reactive bone formation or dystrophic calcifications. The epithelial lining may be hyperplastic and/or ulcerated (11,20,34) . Two types of giant cells have been described: type A cells, which correspond to eosinophilic polynuclear cells with abundant and diffuse cytoplasm and irregular nuclei, containing chromatin spread along the inner membrane; type B cells, which have regular and well-defined shape and more abundant and dense cytoplasm (12,16) .…”

Section: Peripheral Giant Cell Lesionsmentioning

confidence: 99%

“…Two types of giant cells have been described: type A cells, which correspond to eosinophilic polynuclear cells with abundant and diffuse cytoplasm and irregular nuclei, containing chromatin spread along the inner membrane; type B cells, which have regular and well-defined shape and more abundant and dense cytoplasm (12,16) . The differential diagnosis of peripheral giant cell granuloma includes lesions with very similar clinical and histopathological features such as CGCL, pyogenic granuloma, peripheral ossifying fibroma, fibrous hyperplasia, inflamed irritation fibroma, hemangioma, lymphangioma, amelanotic melanoma and metastatic tumors (3,20,21,34) .…”

Section: Peripheral Giant Cell Lesionsmentioning

confidence: 99%

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Peripheral and central giant cell lesions: etiology, origin of giant cells, diagnosis and treatment

Vasconcelos

Vasconcelos²,

Queiroz

2013

J. Bras. Patol. Med. Lab.

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Introduction and objective: The peripheral and central giant cell lesions (PGCL and CGCL) are a group of pathological entities with similar histopathological features and whose origin has not been fully elucidated. The former is reactive and the latter exhibits a nonneoplastic proliferative behavior. This article aims to review the literature on peripheral giant cell lesions (PGCL) and central giant cell lesions (CGCL) by discussing the most important aspects pertaining to each of them. Results: These lesions are found in different locations and show diverse clinical signs despite having the same histopathological features. The treatment consists in the surgical resection by different techniques depending on the type of the lesion and clinical conditions. In the case of CGCL, drug therapy may also be employed. Conclusion: Although there is no consensus in the literature, it is essential to know the etiology of these lesions as well as the exact origin of the giant cells. Due to their singular biological behavior, it is of utmost importance to establish a differential diagnosis between the two lesions and other processes that have similar clinical, radiological and histological characteristics, inasmuch as this procedure is essential to provide a suitable treatment and establish a prognosis.

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“…Previously, the lesion was called peripheral giant cell reparative granuloma. However, its reparative effect has not been proved yet, hence osteoclast activity seems doubtful (11,20,34) .…”

Section: Peripheral Giant Cell Lesionsmentioning

confidence: 99%

Section: Peripheral Giant Cell Lesionsmentioning

confidence: 99%

Section: Peripheral Giant Cell Lesionsmentioning

confidence: 99%

Section: Peripheral Giant Cell Lesionsmentioning

confidence: 99%

Section: Peripheral Giant Cell Lesionsmentioning

confidence: 99%

See 3 more Smart Citations

Peripheral and central giant cell lesions: etiology, origin of giant cells, diagnosis and treatment

Vasconcelos

Vasconcelos²,

Queiroz

2013

J. Bras. Patol. Med. Lab.

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Non‐neoplastic proliferative lesions or soft tissue tumor‐like lesions of the oral cavity

Kern

Nakajima

Vieira

et al. 2015

Lasers in Dentistry

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Peripheral calcifying odontogenic cyst in maxillary anterior gingiva: A case report

Alsabbagh,

Speakman,

Wang

et al. 2024

Clin Adv Periodontics

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BackgroundCalcifying odontogenic cysts (Gorlin cysts) most commonly present centrally and have only rarely been reported in peripheral locations. The purpose of this report is to describe a new case of peripheral calcifying odontogenic cyst (PCOC) occurring in the anterior maxillary gingiva and to review the management and differential diagnosis of such a lesion.MethodsA 37‐year‐old female presented with a long‐standing submucosal nodule on the gingiva between the maxillary central incisors, with asymptomatic growth over the last three years. Following an initial incisional biopsy, a diagnosis of PCOC was established. To exclude the possibility of a central process, a corresponding small field of view cone beam CT scan was obtained and the patient returned for a 6 mm excisional biopsy to the depth of the periosteum.ResultsResults of these additional assessments supported the original diagnosis of PCOC. Following uneventful healing of the second biopsy, no recurrence or other clinical findings were noted at 1‐year follow‐up.ConclusionWhile rare, the peripheral variant of calcifying odontogenic cyst, and other peripheral counterparts to recognized central cysts and tumors, should be considered in a differential diagnosis for a benign gingival nodule. Gingival tissue should be submitted for histologic evaluation to ensure a neoplastic process is not present.Key points Various lesions may present on the gingiva as a “bump”; these can represent common clinical entities, such as pyogenic granuloma, peripheral ossifying fibroma, peripheral giant cell granuloma, and fibroma, or more rare conditions that may not be adequately considered in the differential diagnosis. A rarely documented case of peripheral calcifying odontogenic cyst (PCOC; Gorlin cyst) on the maxillary anterior gingiva of an adult female is reported here and compared with the few other similar PCOC cases in the literature. A biopsy of gingival lesions is always necessary to establish the correct diagnosis and provide the appropriate treatment. Plain language summarySeveral different lesions can appear on the gingiva (gums). Some are quite common, and some are rare. This report documents the occurrence of a new case of calcifying odontogenic cyst (Gorlin cyst), a type of cyst that has been rarely found outside the jawbone, presenting as a “bump” on the gingiva between the maxillary central incisor teeth of an adult female. Because of the patient history, a peripheral calcifying odontogenic cyst (PCOC) was not initially suspected. Following a biopsy, a PCOC diagnosis was given. The possibility of a lesion within the bone was then excluded by an X‐ray (cone beam CT) scan examination. A second, more extensive biopsy confirmed the diagnosis and the removal of the lesion. The patient had no complications or recurrence for the following 12 months. This case highlights the need to always biopsy lesions presenting on the gums to obtain a proper diagnosis and provide the correct treatment.

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Peripheral giant cell granuloma

Cited by 45 publications

References 17 publications

Peripheral and central giant cell lesions: etiology, origin of giant cells, diagnosis and treatment

Peripheral and central giant cell lesions: etiology, origin of giant cells, diagnosis and treatment

Non‐neoplastic proliferative lesions or soft tissue tumor‐like lesions of the oral cavity

Peripheral calcifying odontogenic cyst in maxillary anterior gingiva: A case report

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