Peripheral giant cell granuloma. Clinicopathologic study of 224 new cases and review of 956 reported cases

Katsikeris, Nick; E, Kakarantza-Angelopoulou; Angelopoulos, A.

doi:10.1016/s0901-5027(88)80158-9

Cited by 167 publications

(237 citation statements)

References 9 publications

Supporting

Mentioning

189

Contrasting

Unclassified

Order By: Relevance

“…The interdental papilla is mostly aff ected in dentate patients. [5] The typical presentation is that of a swelling of varying sizes (may range from small papules to enlarged masses); most of them are less 20 mm in diameter. They may be soft to fi rm in consistency and may have a pedunculated or sessile base.…”

Section: Discussionmentioning

confidence: 99%

“…Pain is not a usual feature, though in some cases pain may be induced by repeated trauma. [5,6] Although the PGCG develops within soft tissue, sometimes superfi cial erosion of the underlying alveolar bone may be seen, which is termed as "cupping" of the bone [ Figure 3]. PGCG has to be distinguished from a giant cell lesions arising centrally which erodes the bone and manifests peripherally.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Peripheral giant cell granuloma: A case report and review

Nagaraj¹,

Balraj²,

Sinha³

et al. 2017

IJMDCR

View full text Add to dashboard Cite

Peripheral giant cell granuloma (PGCG) is a reactive entity which is usually benign and manifests exclusively over the alveolar crest or gingiva. The objective of this case report is to illustrate a case of PGCG and to review the possible diff erential diagnoses based on the history elicited by a patient, clinical features and radiological features. The present article reports a case of PGCG evolving from the mandibular alveolar gingiva in a 22-year-old female patient. The lesion was excised surgically and there was no recurrent swelling evident in the biopsied on follow-up. Clinical resemblance of PGCG to pyogenic granuloma, peripheral ossifying fi broma and many other peripheral lesions seen in the oral cavity, necessitates radiologic and histopathologic examinations to aid in the early and accurate diagnosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Peripheral giant cell granuloma: A case report and review

Nagaraj¹,

Balraj²,

Sinha³

et al. 2017

IJMDCR

View full text Add to dashboard Cite

show abstract

“…Radiographic findings are diverse, ranging from small unilocular lesions to large multilocular lesions with displacement of teeth, root resorption, and cortical perforation (2). Peripheral giant cell lesion (PGCL) is a reactive lesion usually related to local irritating factors in gingival (3). Histologically, PGCL and CGCL are characterized by the presence of multinucleated osteoclast-like giant cells in a background of oval to spindle-shaped mononuclear cells (4).…”

Section: Introductionmentioning

confidence: 99%

Clonality analysis of giant cell lesions of the jaws

et al. 2010

View full text Add to dashboard Cite

Despite the importance of clonality to understand the pathogenesis and progression of tumors, it has not been investigated yet in giant cell lesions of the jaws. The aim of this study was to analyze the clonality of peripheral giant cell lesions (PGCL) and central giant cell lesions (CGCL) of the jaws. Six samples of PGCL and 5 samples of CGCL were analyzed in this study using the polymorphic human androgen receptor locus (HUMARA) assay. Three out of the 5 samples of the CGCL and 3 out of 6 samples of PGCL exhibited a monoclonal pattern. Our findings demonstrate that some giant cell lesions of the jaws are clonal, which indicate that these lesions may have a common genetic mechanism of development. Further studies are necessary to better elucidate the molecular mechanisms involved in the pathogenesis of such lesions.

show abstract

“…PCGCs may be associated with local irritating factors, such as tooth extraction, poor dental restorations, food impaction, ill-fitting dentures and dental calculus [8]- [10]. PGCGs can occur at any age, but most commonly are noted between the fourth and sixth decades and appear to be more common in women, with the most prevalent site being the posterior mandibular alveolar mucosa [2] PGCG is histologically indistinguishable from its central counterpart, the central giant cell granuloma (CGCG) and the brown tumor of hyperparathyroidism [14]- [18]. Histologically, these lesions demonstrate abundant multinucleated giant cells in a fibroblastic matrix [2] [4] [19].…”

mentioning

confidence: 99%

“…PGCGs can occur at any age, but most commonly are noted between the fourth and sixth decades and appear to be more common in women, with the most prevalent site being the posterior mandibular alveolar mucosa [2] PGCG is histologically indistinguishable from its central counterpart, the central giant cell granuloma (CGCG) and the brown tumor of hyperparathyroidism [14]- [18]. Histologically, these lesions demonstrate abundant multinucleated giant cells in a fibroblastic matrix [2] [4] [19]. Even though brown tumor, PGCG and CGCG are clinically and histologically similar, lesions from hyperparathyroidism are rarely observed because hyperparathyroidism is typically diagnosed at an early stage.…”

mentioning

confidence: 99%

A Case Report of a Peripheral Giant Cell Granuloma in a Patient on Forteo

Pirih¹,

Barroso²,

Tatarakis³

et al. 2015

OJST

View full text Add to dashboard Cite

Peripheral giant cell granuloma (PGCG) is a common reactive gingival lesion that histologically resembles the central giant cell granuloma, and is a central lesion of the jaws. Occasionally, central giant cell granuloma-like lesions may be seen in association with hyperparathyroidism. Rarely, PGCG-like lesions have been described in a background of hyperparathyroidism. We describe the case of a 91-year-old woman taking teriparatide for the treatment of osteoporosis and presented with a peripheral giant cell granuloma of the mandibular posterior area.

show abstract

Peripheral giant cell granuloma. Clinicopathologic study of 224 new cases and review of 956 reported cases

Cited by 167 publications

References 9 publications

Peripheral giant cell granuloma: A case report and review

Peripheral giant cell granuloma: A case report and review

Clonality analysis of giant cell lesions of the jaws

A Case Report of a Peripheral Giant Cell Granuloma in a Patient on Forteo

Contact Info

Product

Resources

About