Peripheral giant cell granuloma: This enormity is a rarity

Rodrigues, Silvia; Mitra, Dipika; Pawar, Sudarshana Devendrasing; Vijayakar, Harshad

doi:10.4103/0972-124x.152411

Cited by 13 publications

(18 citation statements)

References 5 publications

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“…5 In case of development of PGCG around a tooth, it probably originates from the periodontal ligament 1 ; while, lesions developed at edentulous areas or around dental implants definitely originate from the periosteum and cortical bone. 6 The clinical manifestations of PGCG are similar to those of other proliferating gingival lesions. Thus, its definite diagnosis should be made through histopathological analyses.…”

Section: Introductionmentioning

confidence: 75%

Peripheral giant cell granuloma as a sign of hyperparathyroidism in a patient under hemodialysis: A case report and review of literature

Yousefian,

Aghakouchakzadeh,

Torki

2023

Clinical Case Reports

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Key Clinical MessagePeripheral giant cell granuloma (PGCG) is a benign reactive exophytic oral lesion that originates from the periosteum or the periodontal ligament. It exclusively develops on the gingiva or alveolar mucosa. Hyperparathyroidism (HPT) is a possible etiology for its development. HPT is an endocrine disorder characterized by increased secretion of the parathyroid hormone (PTH). This case report describes a case of recurring PGCG in a patient diagnosed with secondary HPT after paraclinical assessment.

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Section: Introductionmentioning

confidence: 75%

Peripheral giant cell granuloma as a sign of hyperparathyroidism in a patient under hemodialysis: A case report and review of literature

Yousefian,

Aghakouchakzadeh,

Torki

2023

Clinical Case Reports

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“…The exact origin of giant cells is uncertain but it has been suggested that cells like osteoblasts, macrophages, endothelial cells, and spindle cells can give rise to these multinucleated giant cells. [ 23 ]…”

Section: Discussionmentioning

confidence: 99%

Coexistence of hyperparathyroidism and peripheral giant cell granuloma of the jaw: A rare case report

Pattnaik

Rajguru

Pattanaik

et al. 2020

J Family Med Prim Care

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Peripheral giant cell granuloma (PGCG) known as “giant cell epulis” is a benign, reactive exophytic gingival lesion that accounts for less than 10% of all gingival lesions. PGCG affects females more than males with middle age predilection. Till now the etiology of PGCG remains unclear but various factors that can cause PGCG include poor oral hygiene, food impaction, following an extraction, dry mouth, hormonal disturbance, and hyperparathyroidism. The reported recurrence rate of the lesion is 5.0%–70.6%. The present case report describes the rare case of PGCG with primary hyperparathyroidism in a male patient with a history of swelling in the mandibular anterior region.

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“…While periodontal ligament could be involved in the genesis of PGCGs that arise around teeth, periosteum and cortical bone are certainly involved in the cases in which PGCGs arises on edentulous region or around implants. The exact origin of giant cells is uncertain but it has been suggested that cells like osteoblasts, macrophages and also all the monocyte family, and endothelial cells, and spindle cells can give rise to these multinucleated giant cells [ 15 , 16 ].…”

Section: Discussionmentioning

confidence: 99%

Peripheral Giant Cell Granuloma of the Jaws as First Sign of Primary Hyperparathyroidism: A Case Series

Limongelli

Tempesta

Lauritano

et al. 2020

JCM

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Peripheral giant cell granulomas (PGCG) associated with hyperparathyroidism (HPT) are rare clinical entities. The aim of this study is to report on 21 PGCGs of the oral cavity as the first clinical sign of unknown primary HPT (PHPT) referred to the Complex Operating Unit of Odontostomatology of Aldo Moro University of Bari from 2009 to 2019. Surgical treatment consisted in conservative enucleation of the lesion, if possible, with contextual bone rim osteoplasty with piezosurgical tools and following histological examination. After histological diagnosis of PGCG, PHPT screening was performed dosing parathyroid hormone and serum calcium. In all the patients haematological investigation demonstrated elevated values of parathyroid hormone and serum calcium ruling out an unknown PHPT. Specifically, after endocrinological evaluation, patients showed PHPT related to: parathyroid adenoma (13), parathyroid hyperplasia (two, one of which occurred in a intra-thyroidal parathyroid), and parathyroid carcinoma (1) and were scheduled for surgical treatment. Considering that PGCGs could represent the first clinical sign of an undiagnosed PHPT and the screening of PHPT is a non-invasive and cheap exam, in case of histological diagnosis of a giant cell lesion, both central and peripheral, especially in patients with synchronous or history of methacronous giant cell lesions, parathyroidal screening should be mandatory.

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Peripheral giant cell granuloma: This enormity is a rarity

Cited by 13 publications

References 5 publications

Peripheral giant cell granuloma as a sign of hyperparathyroidism in a patient under hemodialysis: A case report and review of literature

Peripheral giant cell granuloma as a sign of hyperparathyroidism in a patient under hemodialysis: A case report and review of literature

Coexistence of hyperparathyroidism and peripheral giant cell granuloma of the jaw: A rare case report

Peripheral Giant Cell Granuloma of the Jaws as First Sign of Primary Hyperparathyroidism: A Case Series

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