Peripheral immunomodulation with ginsenoside Rg1 ameliorates neuroinflammation-induced behavioral deficits in rats

Zheng, Xiao; Liang, Yan; An, Kang; Ma, Shengming; Xing, Lianxi; Zhou, Ying; Dai, Chen; Xie, Hang; Xie, Lin; Wang, G.-J.; Hao, Haiping

doi:10.1016/j.neuroscience.2013.10.023

Cited by 56 publications

(48 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…LPS is well known for its ability to produce sickness behaviors in preclinical (14,(38)(39)(40)(41) and clinical (33,36,42) studies, and it is thought that these symptoms result from the effect on the brain of the increases in blood serum levels of cytokines. Subjects were asked to rate sickness symptoms (fatigue, headache, muscle pain, and shivering) on a scale from 0 (least) to 4 (most) before and at various time points after LPS administration (Fig.…”

Section: Lps Administration Induces Sickness Symptoms and Related Behmentioning

confidence: 99%

Imaging robust microglial activation after lipopolysaccharide administration in humans with PET

Sandiego

Gallezot

Pittman

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

287

220

View full text Add to dashboard Cite

Neuroinflammation is associated with a broad spectrum of neurodegenerative and psychiatric diseases. The core process in neuroinflammation is activation of microglia, the innate immune cells of the brain. We measured the neuroinflammatory response produced by a systemic administration of the Escherichia coli lipopolysaccharide (LPS; also called endotoxin) in humans with the positron emission tomography (PET) radiotracer [ 11 C]PBR28, which binds to translocator protein, a molecular marker that is up-regulated by microglial activation. In addition, inflammatory cytokines in serum and sickness behavior profiles were measured before and after LPS administration to relate brain microglial activation with systemic inflammation and behavior. Eight healthy male subjects each had two 120-min [ 11 C]PBR28 PET scans in 1 d, before and after an LPS challenge. LPS (1.0 ng/kg, i.v.) was administered 180 min before the second [ 11 C]PBR28 scan. LPS administration significantly increased [ 11 C]PBR28 binding 30-60%, demonstrating microglial activation throughout the brain. This increase was accompanied by an increase in blood levels of inflammatory cytokines, vital sign changes, and sickness symptoms, well-established consequences of LPS administration. To our knowledge, this is the first demonstration in humans that a systemic LPS challenge induces robust increases in microglial activation in the brain. This imaging paradigm to measure brain microglial activation with [ 11 C]PBR28 PET provides an approach to test new medications in humans for their putative antiinflammatory effects.neuroinflammation | PBR28 | endotoxin | microglia | cytokines

show abstract

Section: Lps Administration Induces Sickness Symptoms and Related Behmentioning

confidence: 99%

Imaging robust microglial activation after lipopolysaccharide administration in humans with PET

Sandiego

Gallezot

Pittman

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

287

220

View full text Add to dashboard Cite

show abstract

“…Minocycline's antidepressant potential has been documented using animal models of depression, with most studies indicating improvement in outcomes following both peripheral and direct CNS administration . Pro‐cognitive effects, including improvements in spatial as well as non‐spatial learning and memory, have likewise been observed in animal models of depression .…”

Section: Introductionmentioning

confidence: 99%

A pilot, open‐label, 8‐week study evaluating the efficacy, safety and tolerability of adjunctive minocycline for the treatment of bipolar I/II depression

et al. 2017

View full text Add to dashboard Cite

show abstract

“…And there are others reported to be flavonoids, cyclopeptides, saccharides and inorganic elements [30]. Pharmacological studies have shown that notoginseng and its extracts have many functions, such as anti-inflammatory [16,20,31,32], anti-oxidation, inhibition of platelet aggregation, regulation of blood glucose [27,33,34], blood pressure [35][36][37], inhibition of neuronal apoptosis [14,38,39] and neuronal protection [30].…”

Section: Introductionmentioning

confidence: 99%

“…Experiments also have shown that PNS modulates Na + currents and Ca 2+ concentrations, increases nestin and brain-derived neurotrophic factor (BDNF) [14,19,29,[43][44][45][46][47]. Moreover, PNS or single compounds exerted antidepressant-like effects by regulating the release of interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF)-α or anti-inflammatory cytokines IL-4 and IL-10 [10,20,29,31,32,36,[48][49][50][51][52][53][54][55][56]. Such breakthroughs have been made, there is antidepressant effects on estrogen in the human body.…”

Section: Introductionmentioning

confidence: 99%

Panax Notoginseng Saponins: A Review of Its Mechanisms of Antidepressant or Anxiolytic Effects and Network Analysis on Phytochemistry and Pharmacology

Xie¹,

Meng²,

Zhai³

et al. 2018

Preprint

View full text Add to dashboard Cite

Panax notoginseng, as traditional Chinese medicine, has a long history of high clinical value, such as anti-inflammatory, anti-oxidation, inhibition of platelet aggregation, regulation of blood glucose and blood pressure, inhibition of neuronal apoptosis and neuronal protection, and its main ingredients are Panax notoginseng saponins (PNS). Currently, Panax notoginseng may improve mental function, have anti-insomnia and anti-depression effects, alleviate anxiety, and decrease neural network excitation. However, the underlying effects and the mechanisms of Panax notoginseng and its containing chemical constituents (PNS) on these depression-related or anxiety-related diseases has not been completely established. This review summarized the antidepressant or anxiolytic effects and mechanisms of PNS, and analyzed network targets of antidepressant or anxiolytic actions with network pharmacology tools to provide directions and references for further pharmacological studies and new ideas for clinical treatment of nervous system diseases and drug studies and development.

show abstract

Peripheral immunomodulation with ginsenoside Rg1 ameliorates neuroinflammation-induced behavioral deficits in rats

Cited by 56 publications

References 74 publications

Imaging robust microglial activation after lipopolysaccharide administration in humans with PET

Imaging robust microglial activation after lipopolysaccharide administration in humans with PET

A pilot, open‐label, 8‐week study evaluating the efficacy, safety and tolerability of adjunctive minocycline for the treatment of bipolar I/II depression

Panax Notoginseng Saponins: A Review of Its Mechanisms of Antidepressant or Anxiolytic Effects and Network Analysis on Phytochemistry and Pharmacology

Contact Info

Product

Resources

About