Peripheral inflammatory cytokines and motor symptoms in persons with Parkinson's disease

Diaz, Kasandra; Kohut, Marian L.; Stegemöller, Elizabeth L.

doi:10.1016/j.bbih.2022.100442

Cited by 17 publications

(9 citation statements)

References 55 publications

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“…The results of the present study suggested that MCI people had higher scores of SIRI and SII; DII was correlated with SIRI in MCI patients; DII, SIRI and SII were negatively correlated with the MoCA score. A recent study explored the upregulation of inflammatory biomarkers such as TNF-α and IL-1β in people with cognitive decline [52]. Our results might provide a new perspective on this relationship.…”

Section: Discussionmentioning

confidence: 56%

Association of Dietary Inflammatory Potential with Blood Inflammation: The Prospective Markers on Mild Cognitive Impairment

Wang

et al. 2022

Nutrients

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Inflammation is known as an important mechanism of cognitive dysfunction. Systemic immune inflammation index (SII) and system inflammation response index (SIRI) are two blood inflammatory markers, which are related to many chronic diseases including cognitive impairment. It is recognized that dietary inflammatory index (DII), which is used to estimate the overall inflammatory potential of diet, may be related to mild cognitive impairment (MCI) as well. This study aimed to explore the relationship between SII, SIRI and DII, as well as the role of these inflammatory indexes on MCI in elderly people. A total of 1050 participants from Beijing were included. Neuropsychological tests were used for cognitive evaluation. Energy-adjusted DII scores were calculated based on semi-quantitative food frequency questionnaire. Blood samples were tested for calculating SII and SIRI. Log-binomial regression models were used to estimate the correlation of indexes. After adjusting demographic characteristics, SII and SIRI in MCI individuals were higher than controls (p ≤ 0.001). DII, SII and SIRI had positive relationship with MoCA scores (p < 0.005). DII also correlated with SIRI in MCI (β = 0.11, p = 0.031). Higher DII and SIRI could definitely increase the risk of MCI, as well as DII and SII (p < 0.005). In conclusion, DII was positively correlated with blood inflammation. The elderly with higher level of DII and SIRI, or DII and SII could be considered as people with higher risk of developing MCI.

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Section: Discussionmentioning

confidence: 56%

Association of Dietary Inflammatory Potential with Blood Inflammation: The Prospective Markers on Mild Cognitive Impairment

Wang

et al. 2022

Nutrients

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“…Serum immune marker levels are also influenced by a number of other factors, such as diet, body mass index, sleep, smoking, thyroid hormone levels, exercise, coffee use, frailty, or depression, and can, therefore, be regarded as non-specific [28,29]. These elements might have influenced how this study resulted [40][41][42][43][44]. Therefore, results from such studies should be evaluated with the proper caution in light of all these uncontrollable factors.…”

Section: Discussionmentioning

confidence: 99%

Peripheral Inflammatory Markers TNF-α and CCL2 Revisited: Association with Parkinson’s Disease Severity

Xiromerisiou

Marogianni

Lampropoulos

et al. 2022

IJMS

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One of the major mediators of neuroinflammation in PD is tumour necrosis factor alpha (TNF-α), which, similar to other cytokines, is produced by activated microglia and astrocytes. Although TNF-α can be neuroprotective in the brain, long-term neuroinflammation and TNF release can be harmful, having a neurotoxic role that leads to death of oligodendrocytes, astrocytes, and neurons and, therefore, is associated with neurodegeneration. Apart from cytokines, a wide family of molecules with homologous structures, namely chemokines, play a key role in neuro-inflammation by drawing cytotoxic T-lymphocytes and activating microglia. The objective of the current study was to examine the levels of the serum TNF-α and CCL2 (Chemokine (C-C motif) ligand 2), also known as MCP-1 (Monocyte Chemoattractant Protein-1), in PD patients compared with healthy controls. We also investigated the associations between the serum levels of these two inflammatory mediators and a number of clinical symptoms, in particular, disease severity and cognition. Such an assessment may point to their prognostic value and provide some treatment hints. PD patients with advanced stage on the Hoehn–Yahr scale showed an increase in TNF-α levels compared with PD patients with stages 1 and 2 (p = 0.01). Additionally, the UPDRS score was significantly associated with TNF-α levels. CCL2 levels, however, showed no significant associations.

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“…Increased levels of these inflammatory mediators in the elderly represent a highly significant risk factor for most age-related diseases, including obesity, type 2 diabetes, osteoporosis, cancer, cardiovascular and neurodegenerative diseases [ 18 , 19 , 20 , 21 , 22 ]. For example, TNF-α, IL-1β and IL-6 cytokine levels are increased in the parkinsonian brain and serum [ 22 , 23 , 24 , 25 ], while the CCL2 chemokine level is raised in neuroinflammation associated to neurodegenerative diseases [ 26 , 27 ]. CXCL10 has been shown to be a biomarker for heart failure development and left ventricular dysfunction [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Hydroxytyrosol Interference with Inflammaging via Modulation of Inflammation and Autophagy

Velotti

Bernini

2023

Nutrients

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Inflammaging refers to a chronic, systemic, low-grade inflammation, driven by immune (mainly macrophages) and non-immune cells stimulated by endogenous/self, misplaced or altered molecules, belonging to physiological aging. This age-related inflammatory status is characterized by increased inflammation and decreased macroautophagy/autophagy (a degradation process that removes unnecessary or dysfunctional cell components). Inflammaging predisposes to age-related diseases, including obesity, type-2 diabetes, cancer, cardiovascular and neurodegenerative disorders, as well as vulnerability to infectious diseases and vaccine failure, representing thus a major target for anti-aging strategies. Phenolic compounds—found in extra-virgin olive oil (EVOO)—are well known for their beneficial effect on longevity. Among them, hydroxytyrosol (HTyr) appears to greatly contribute to healthy aging by its documented potent antioxidant activity. In addition, HTyr can modulate inflammation and autophagy, thus possibly counteracting and reducing inflammaging. In this review, we reference the literature on pure HTyr as a modulatory agent of inflammation and autophagy, in order to highlight its possible interference with inflammaging. This HTyr-mediated activity might contribute to healthy aging and delay the development or progression of diseases related to aging.

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Peripheral inflammatory cytokines and motor symptoms in persons with Parkinson's disease

Cited by 17 publications

References 55 publications

Association of Dietary Inflammatory Potential with Blood Inflammation: The Prospective Markers on Mild Cognitive Impairment

Association of Dietary Inflammatory Potential with Blood Inflammation: The Prospective Markers on Mild Cognitive Impairment

Peripheral Inflammatory Markers TNF-α and CCL2 Revisited: Association with Parkinson’s Disease Severity

Hydroxytyrosol Interference with Inflammaging via Modulation of Inflammation and Autophagy

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