Peripheral injected cholecystokinin-8S modulates the concentration of serotonin in nerve fibers of the rat brainstem

Engster, Kim-Marie; Frommelt, Lisa; Hofmann, Tobias; Nolte, Sandra; Fischer, Felix; Rose, Matthias; Stengel, Andreas; Kobelt, Peter

doi:10.1016/j.peptides.2014.07.003

Cited by 6 publications

(2 citation statements)

References 48 publications

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“…Cholecystokinin control intestinal motility (Schultzberg et al 1980). Gibbs et al (1973) detected that exogenous CCK prohibits dietary intake and also in rodents (Lembke et al 2011;Bewick 2012;Engster et al 2014). CCK can regulate the contraction of the gallbladder, the secretion and the growth of the pancreas, the gastric emptying, the duodenal secretion, satiety, glucose homoeostasis and insulin secretion (Wattez et al 2013).…”

Section: Cholecystokinin (Cck)mentioning

confidence: 99%

Ingestive Peptides – An Emerging Tool for Diagnostics and Therapeutics: A Review

2021

Int J Vet Sci

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Peptides are relatively safe, well tolerated, highly selective and efficacious. Consequently, in recent years, peptides have acquired an increased interest as therapeutics in pharmaceutical research and development. In clinical trials, about 140 peptide therapeutics are currently being tested. In medicine and biotechnology, peptides have acquired a broad range of applications. More than 7000 peptides in nature have been recognized, and these peptides also have critical roles including actions as hormones, growth factors, neurotransmitters, ion channel ligands, or anti-infectives. Peptides are often excellent biomarkers and can be used for diagnostic purposes. Metabolic diseases and oncology are the major disease areas nowadays driving the clinical use of peptide drugs. We think that the future peptide drugs development will be a new tool for the several pathologies amelioration.

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Section: Cholecystokinin (Cck)mentioning

confidence: 99%

Ingestive Peptides – An Emerging Tool for Diagnostics and Therapeutics: A Review

2021

Int J Vet Sci

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“…As described previously, there is a “NTS-PVH” loop linking to the “gut-vagus-NTS-septum-hippocampus” pathway. Intraperitoneal injection of cholecystokinin-8S increases the amount of activated neurons in the NTS and PVH [ 120 ], while activating the NTS cholecystokinin axon terminals within the PVH affects appetite [ 87 , 121 ], suggesting the effects on the gut pathway. The vagus nerve stimulation reduces the CRH/adrenocorticotropic hormone responses in the depressed subjects [ 122 ], suggesting the potential connection between the vagus and the HPA axis.…”

Section: Crosstalk Between the Gabaergic System And The Gut-brain mentioning

confidence: 99%

GABAergic System in Stress: Implications of GABAergic Neuron Subpopulations and the Gut-Vagus-Brain Pathway

et al. 2020

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Stress can cause a variety of central nervous system disorders, which are critically mediated by the γ-aminobutyric acid (GABA) system in various brain structures. GABAergic neurons have different subsets, some of which coexpress certain neuropeptides that can be found in the digestive system. Accumulating evidence demonstrates that the gut-brain axis, which is primarily regulated by the vagus nerve, is involved in stress, suggesting a communication between the “gut-vagus-brain” pathway and the GABAergic neuronal system. Here, we first summarize the evidence that the GABAergic system plays an essential role in stress responses. In addition, we review the effects of stress on different brain regions and GABAergic neuron subpopulations, including somatostatin, parvalbumin, ionotropic serotonin receptor 5-HT3a, cholecystokinin, neuropeptide Y, and vasoactive intestinal peptide, with regard to signaling events, behavioral changes, and pathobiology of neuropsychiatric diseases. Finally, we discuss the gut-brain bidirectional communications and the connection of the GABAergic system and the gut-vagus-brain pathway.

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Neuroendocrine Peptides of the Gut and Their Role in the Regulation of Food Intake

Schalla

Taché

Stengel

2021

Comprehensive Physiology

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The regulation of food intake encompasses complex interplays between the gut and the brain. Among them, the gastrointestinal tract releases different peptides that communicate the metabolic state to specific nuclei in the hindbrain and the hypothalamus. The present overview gives emphasis on seven peptides that are produced by and secreted from specialized enteroendocrine cells along the gastrointestinal tract in relation with the nutritional status. These established modulators of feeding are ghrelin and nesfatin-1 secreted from gastric X/A-like cells, cholecystokinin (CCK) secreted from duodenal I-cells, glucagon-like peptide 1 (GLP-1), oxyntomodulin, and peptide YY (PYY) secreted from intestinal L-cells and uroguanylin (UGN) released from enterochromaffin (EC) cells.

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Peripheral injected cholecystokinin-8S modulates the concentration of serotonin in nerve fibers of the rat brainstem

Cited by 6 publications

References 48 publications

Ingestive Peptides – An Emerging Tool for Diagnostics and Therapeutics: A Review

Ingestive Peptides – An Emerging Tool for Diagnostics and Therapeutics: A Review

GABAergic System in Stress: Implications of GABAergic Neuron Subpopulations and the Gut-Vagus-Brain Pathway

Neuroendocrine Peptides of the Gut and Their Role in the Regulation of Food Intake

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