Peripheral injection of bombesin induces c-Fos in NUCB2/nesfatin-1 neurons

Engster, Kim-Marie; Kroczek, Arthur L.; Rose, Matthias; Stengel, Andreas; Kobelt, Peter

doi:10.1016/j.brainres.2016.07.006

Cited by 6 publications

(2 citation statements)

References 62 publications

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“…Noteworthy, the elevation of nesfatin-1 gene expression was connected with the light phase in normal individuals, while in Zucker-fatty rats with knock out leptin receptor this circadian pattern of changes is disturbed (Sedbazar et al 2013). Peripherally administered bombesin and cholecystokinin (CCK-8S) can also activate nesfatin-1 neurons (Engster et al 2016, Noetzel et al 2009. Conversely, POMC-derived-a-MSH increased calcium concentration in the PVN nesfatin-1 (Sedbazar et al 2014).…”

Section: Animal Studiesmentioning

confidence: 99%

The potential role of the novel hypothalamic neuropeptides nesfatin-1, phoenixin, spexin and kisspeptin in the pathogenesis of anxiety and anorexia nervosa

Pałasz

Janas–Kozik

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et al. 2018

Neurochemistry International

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Due to the dynamic development of molecular neurobiology and bioinformatic methods several novel brain neuropeptides have been identified and characterized in recent years. Contemporary techniques of selective molecular detection e.g. in situ Real-Time PCR, microdiffusion and some bioinformatics strategies that base on searching for single structural features common to diverse neuropeptides such as hidden Markov model (HMM) have been successfully introduced. A convincing majority of neuropeptides have unique properties as well as a broad spectrum of physiological activity in numerous neuronal pathways including the hypothalamus and limbic system. The newly discovered but uncharacterized regulatory factors nesfatin-1, phoenixin, spexin and kisspeptin have the potential to be unique modulators of stress responses and eating behaviour. Accumulating basic studies revelaed an intriguing role of these neuropeptides in the brain pathways involved in the pathogenesis of anxiety behaviour. Nesfatin-1, phoenixin, spexin and kisspeptin may also distinctly affect the energy homeostasis and modulate food intake not only at the level of hypothalamic centres. Moreover, in patients suffered from anxiety and anorexia nervosa a significant, sex-related changes in the plasma neuropeptide levels occurred. It should be therefore taken into account that the targeted pharmacomodulation of central peptidergic signaling may be potentially helpful in the future treatment of certain neuropsychiatric and metabolic disorders. This article reviews recent evidence dealing with the hypothetical role of these new factors in the anxiety-related circuits and pathophysiology of anorexia nervosa.

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Section: Animal Studiesmentioning

confidence: 99%

The potential role of the novel hypothalamic neuropeptides nesfatin-1, phoenixin, spexin and kisspeptin in the pathogenesis of anxiety and anorexia nervosa

Pałasz

Janas–Kozik

Borrow

et al. 2018

Neurochemistry International

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“…Amphibian skin bombesin-like peptides and their mammalian homologues have been shown to elicit various biological effects including direct action on extravascular smooth muscles, regulation of exocrine and endocrine secretion, autocrine tumour-growth effects, thermoregulation and mediation of satiety [ 11 , 17 , 18 , 19 , 20 , 21 ]. Such profound pharmacological effectiveness not only enables frogs to defend themselves against attacking predators like snakes, birds or mammals, but also provides scientists with many clues for understanding some aspects of disease pathogenesis and may assist in the diagnosis and/or therapy of some diseases.…”

Section: Introductionmentioning

confidence: 99%

Ranatensin-HL: A Bombesin-Related Tridecapeptide from the Skin Secretion of the Broad-Folded Frog, Hylarana latouchii

et al. 2017

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Bombesin-related peptides are a family of peptides whose prototype was discovered in amphibian skin and which exhibit a wide range of biological activities. Since the initial isolation of bombesin from Bombina bombina skin, diverse forms of bombesin-related peptides have been found in the skins across Anura. In this study, a novel bombesin-related peptide of the ranatensin subfamily, named ranatensin-HL, was structurally-characterised from the skin secretion of the broad-folded frog, Hylarana latouchii, through combination of molecular cloning and mass spectrometric methodologies. It is composed of 13 amino acid residues, pGlu-RAGNQWAIGHFM-NH2, and resembles an N-terminally extended form of Xenopus neuromedin B. Ranatensin-HL and its C-terminal decapeptide (ranatensin-HL-10) were chemically synthesised and subjected to in vitro smooth muscle assays in which they were found to display moderate stimulatory effects on rat urinary bladder and uterus smooth muscles with EC50 values in the range of 1–10 nM. The prepro-ranatensin-HL was highly homological to a bombesin-like peptide from Rana catesbeiana at both nucleotide and amino acid levels, which might provide a clue for the taxonomic classification of ranid frogs in the future.

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Bombesin attenuated ischemia-induced spatial cognitive and synaptic plasticity impairment associated with oxidative damage

Yao

Wang

Yang

et al. 2018

Biomedicine & Pharmacotherapy

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Peripheral injection of bombesin induces c-Fos in NUCB2/nesfatin-1 neurons

Cited by 6 publications

References 62 publications

The potential role of the novel hypothalamic neuropeptides nesfatin-1, phoenixin, spexin and kisspeptin in the pathogenesis of anxiety and anorexia nervosa

The potential role of the novel hypothalamic neuropeptides nesfatin-1, phoenixin, spexin and kisspeptin in the pathogenesis of anxiety and anorexia nervosa

Ranatensin-HL: A Bombesin-Related Tridecapeptide from the Skin Secretion of the Broad-Folded Frog, Hylarana latouchii

Bombesin attenuated ischemia-induced spatial cognitive and synaptic plasticity impairment associated with oxidative damage

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