Peripheral insulin resistance during treatment of chronic hepatitis C with peguilated interferon plus ribavirin

Mello, Vivianne; Cruz, Thomaz; Nuñez, Geila Ribeiro; Simoes, M T; Ney-Oliveira, Fabrizio; Braga, Hélio; Araújo, César; Cunha, Sílvio; Schinoni, María Isabel; Cruz, Marla; Paraná, Raymundo

doi:10.1002/jmv.20712

Cited by 14 publications

(12 citation statements)

References 17 publications

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“…In the bivariate analysis, IR was associated with age and anthropometric factors (BMI, waist circumference and weight categories); however, this association was not found in the multivariate analysis. Some studies also showed the association of age, waist circumference, and BMI to IR among HCV patients (9,10,11,13,18). IR was also associated with higher mean values of triglycerides and is most likely the result of the characteristics of the HCV replication cycle.…”

Section: Discussionmentioning

confidence: 97%

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High prevalence of insulin resistance among Brazilian chronic hepatitis C patients

Villar

Caldas

Scalioni

et al. 2017

Arch. Endocrinol. Metab.

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Objective: This study aims to estimate the prevalence of insulin resistance (IR) among chronic hepatitis C (CHC) patients and their related laboratory and demographic data. Subjects and methods: In this study, non-diabetic CHC patients referred to Viral Hepatitis Ambulatories from Rio de Janeiro (Brazil) donated blood samples. Insulin was measured using a chemiluminescence immunoassay. IR was determined by HOMA-IR, where HOMA-IR > 2 was defined as IR. Results: A total of 214 CHC patients were recruited (123 females aged 53.6 years ± 10.9 years). IR was present in 133 patients (62.1%) and was associated in bivariate analysis to higher mean values of age (p = 0.040), triglycerides (p = 0.032), glucose (p = 0.000), insulin (p = 0.000), waist circumference (p = 0.001), and body mass index (p = 0.007); however, none of these variables were significant in the multivariate analysis. Conclusions: The high prevalence of IR was observed among CHC patients, and there was no difference in clinical or laboratory parameters when both groups were compared in the multivariate analysis. This high IR prevalence could lead to a high risk for development of cardiovascular disease and metabolic disorders. Arch Endocrinol Metab. 2017;61(6):628-32

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Section: Discussionmentioning

confidence: 97%

“…Some studies showed that more than 50% of HCV infected individuals have IR (8,9). In Brazil, IR prevalence varies from 20 to 80% in HCV patients (9)(10)(11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

High prevalence of insulin resistance among Brazilian chronic hepatitis C patients

Villar

Caldas

Scalioni

et al. 2017

Arch. Endocrinol. Metab.

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“…All these considerations seem very interesting for the therapeutic approach regarding, for example, lifestyle changes (weight loss, abolition of alcohol consumption, cardio-vascular control) and metformin or peroxisome proliferator activated receptor -agonists assumption [11][12][13][14][15][16][17].…”

Section: Hcv and Diabetes Mellitusmentioning

confidence: 99%

HCV and Diabetes Mellitus: Considerations About Effects of Interferon Therapy

Reynaud¹,

Carleo²,

Talamo³

et al. 2007

TOPHARMJ

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Nowadays HCV-related chronic hepatitis represents one of the main challenge for infectious diseases for many reasons: the dimension of the phenomenon, as millions of patients are afflicted with this pathology in the world, the dramatic consequences on the quality of their life, the economic and sanitary efforts sustained by the society, but also the stimulating results in therapeutic approach due to the introduction of interferons in monotherapy first and association therapy (IFN plus ribavirin) later in modern protocols. The results obtained with these therapies are very encouraging even if medical doctors and patients know very well that this therapy is related to some side effects that grow dramatically in number with the progression of scientific knowledge. The Authors review the literature on the relationship among HCV, IFN therapy and diabetes to understand better damages and benefits of this long debated matter and possibly add their contribution to clinical and therapeutic strategies.

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“…Besides this, it is possible that liver siderosis and alterations in the levels of circulating adipocytokines might as well have a role in insulin sensitivity in CHC (39) . Nevertheless, Mello et al (35) failed to find an enhancement in insulin resistance, evaluated by HOMA (homeostatic model assessment), with the treatment of HCV.…”

Section: Introductionmentioning

confidence: 99%

Analysis of the sustained virological response in patients with chronic hepatitis C and liver steatosis

Piccoli

Mattos

Coral

et al. 2011

Arq. Gastroenterol.

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-Context -Chronic hepatitis C as well as non-alcoholic fatty liver disease are recognized as the main cause of liver disease in Western countries. It is common to see the concomitance of the diseases and the influence of steatosis in the sustained virological response of patients with hepatitis C virus. Objective -Assess the sustained virological response in chronic hepatitis C patients according to the presence of liver steatosis. Methods -One hundred sixty patients with chronic hepatitis C were retrospectively evaluated. Demographic data such as gender, age, body mass index, presence of diabetes mellitus and systemic arterial hypertension, virus genotype and use of pegylated interferon were analyzed, as was the staging of fibrosis and the presence of steatosis at histology. Results -Most patients were male (57.5%), with a mean age of 48 ± 9.7 years. The most frequent genotype observed was 3 (56.9%) and, in the histological evaluation, steatosis was observed in 65% of the patients (104/160). Sustained virological response in patients with steatosis occurred in 38.5%, and in 32.1% in patients without steatosis (P = 0.54). When we analyzed possible factors associated with the presence of steatosis, only body mass index and systemic arterial hypertension revealed a significant association. When the factors that influenced sustained virological response were evaluated in a logistic regression, genotype and use of pegylated interferon proved to be independent factors associated to the response. Conclusion -In the evaluated patients the presence of liver steatosis did not influence the sustained virological response of patients with chronic hepatitis C treated with interferon and ribavirin.

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Peripheral insulin resistance during treatment of chronic hepatitis C with peguilated interferon plus ribavirin

Abstract: No changes in the IR were observed after 6 months of treatment. Insulin resistance is related to the abdominal fat and anthropometrical parameters rather than to the antiviral treatment.

Cited by 14 publications

References 17 publications

High prevalence of insulin resistance among Brazilian chronic hepatitis C patients

High prevalence of insulin resistance among Brazilian chronic hepatitis C patients

HCV and Diabetes Mellitus: Considerations About Effects of Interferon Therapy

Analysis of the sustained virological response in patients with chronic hepatitis C and liver steatosis

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